Drug & supplement interaction

Star Of Bethlehem + Metoproterenol

Metoproterenol brand name: Alupent.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Star Of Bethlehem and Metoproterenol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Star Of Bethlehem and Metoproterenol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metoproterenol and Star Of Bethlehem in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Star Of Bethlehem safety at a glance

Star Of Bethlehem overall Use caution The plant and bulb are toxic if eaten; commercial flower essences are very dilute but lack good safety studies.
Pregnancy Likely Unsafe When used orally. Star of Bethlehem contains toxic cardiac glycosides. Ingestion of star of Bethlehem could result in serious adverse effects. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Star of Bethlehem contains toxic cardiac glycosides. Ingestion of star of Bethlehem could result in serious adverse effects. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metoproterenol and Star Of Bethlehem? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metoproterenol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metoproterenol is filed under a single classification — beta-adrenergic agonists. Star Of Bethlehem has documented interactions with 7 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Metoproterenol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Star Of Bethlehem Does Interact With Other Medications

Star Of Bethlehem has 156 moderate known drug interactions in our database — Metoproterenol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 156 No known interaction 2,674 (incl. Metoproterenol)
Taking anything else?

Check Another of Your Medications Against Star Of Bethlehem

Covers the 2,830 medications we’ve checked against Star Of Bethlehem. Pick one to open its full report.

What to actually watch for

What Star Of Bethlehem Itself Has Been Linked To

This is not an interaction — nothing below involves Metoproterenol. It is the side-effect record for Star Of Bethlehem on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Star Of Bethlehem, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    “Star of Bethlehem contains cardiac glycosides, which can cause serious adverse effects.

    Serious Adverse Effects (Rare):

    Orally: Star of Bethlehem contains toxic cardiac glycosides that can cause cardiac arrhythmia and death.”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in arrhythmia.

    “Orally, the cardiac glycosides in star of Bethlehem can cause cardiac arrhythmias (2).”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in arrhythmia.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  • Vomiting / Nausea Additional detail

    “Orally, the cardiac glycosides in star of Bethlehem can cause nausea and vomiting (2).”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  • Headache Additional detail

    “Orally, the cardiac glycosides in star of Bethlehem can cause headache and stupor (18). Visual color disturbances can also occur (18).”

    Star Of Bethlehem · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Star Of Bethlehem — expand a row for the licensed statement it rests on. We haven’t matched Metoproterenol to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Metoproterenol.

Special populations

Star Of Bethlehem in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally. Star of Bethlehem contains toxic cardiac glycosides. Ingestion of star of Bethlehem could result in serious adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Metoproterenol

This page covers Star Of Bethlehem only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoproterenol page lists 15 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Black Tea (moderate), Caffeine (moderate), Cocoa (moderate), Coffee (moderate) and Cola Nut (moderate).

By severity: 15 moderate.

From our pharmacist’s overview on the Metoproterenol page

“Someone using metoproterenol (Alupent) for asthma or COPD is taking a beta-agonist, a drug that opens airways by stimulating the same receptors that speed the heart, and every one of the 15 supplement interactions on file works through that pathway. Twelve are caffeine sources, everyday things like coffee and tea, where large amounts c…”

Reviewed by 2 · Jul 18, 2026

Open the Metoproterenol interaction page

One more smart check

Taking Star Of Bethlehem as Part of a Dietary Supplement Product? Check It for Interactions

We hold 15 real supplement products containing Star Of Bethlehem, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Star Of Bethlehem. Even though Star Of Bethlehem itself has no known interaction with Metoproterenol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Star Of Bethlehem and Metoproterenol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Star Of Bethlehem
Top half

#665 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metoproterenol
Steady interest

#1,736 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Star Of Bethlehem reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Star Of Bethlehem and Metoproterenol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Star Of Bethlehem

What is Star Of Bethlehem?

  • Emotional shock and trauma
  • Grief and bereavement
  • Stress relief
  • Calming and comfort

Star of Bethlehem is a small flowering plant best known as one of the ingredients in Bach flower remedies, where it is used for emotional shock and grief. There is no solid scientific evidence that it treats any medical condition, and the raw plant and bulb are considered toxic, so it should not be eaten. If you choose to use a flower-essence product, treat it as a complement to—not a replacement for—proper medical care.

Ornithogalum umbellatum · Asparagaceae · Flowers (used in flower remedies); bulb in some traditional preparations · Flower essence (Bach flower remedy), liquid drops, often part of blends

An interaction check asks whether these two react with each other — it does not ask whether Star Of Bethlehem is a good idea for someone in your situation. Here is what our Star Of Bethlehem record says about it on its own.

Star Of Bethlehem: dosing

There is no established standard dose for Star of Bethlehem, and no medical dosing has been proven safe or effective. Flower-essence products are typically taken as a few drops by mouth or in water, following the directions on the label.If you choose to use a product, follow the manufacturer's instructions and do not exceed them. Never make your own preparation from the wild plant.

From our Star Of Bethlehem monograph — the full record covers uses, side effects and every documented interaction.

Read the full Star Of Bethlehem monograph & all interactions
Medication

About Metaproterenol

What Is Metaproterenol Used For?

Brand name: Alupent

  • Metaproterenol is used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.

See full Metaproterenol drug information
Keep checking

Other Drugs & Star Of Bethlehem

Browse every other medication we’ve checked against Star Of Bethlehem — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
156Moderate
0Minor
2,673No known interaction
156 Moderate 2,673 No interaction
Moderate

156 interactions

Showing 60 of 156 moderate interactions — see all 156 on the Star Of Bethlehem page.

No interaction 2,673 drugs checked — show the list

We also checked Star Of Bethlehem against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,673 medications checked with no known interaction — see the full Star Of Bethlehem list.

See the full Star Of Bethlehem interactions page
See every supplement checked against Metoproterenol, ranked by severity
Evidence & sources

Star Of Bethlehem References

The 8 references that drive our Star Of Bethlehem monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
  6. Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.
  7. Vogelsang A. Clinical trial of Ornithogalum umbellatum on the human heart; preliminary report. Can Med Assoc J 1955;73:295-6.
  8. Smith JA, Paterson GR. Rhodexin A and rhodexoside in Ornithogalum umbellatum. J Pharm Pharmacol 1967;19:221-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Star Of Bethlehem and Metoproterenol Together: Common Questions

Is it safe to take Star Of Bethlehem with Metoproterenol?
We do not list a known interaction between Star Of Bethlehem and Metoproterenol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Star Of Bethlehem and Metoproterenol combination checked?
Interactions in our licensed database are recorded against drug classes. Metoproterenol is filed under 1 classification, and Star Of Bethlehem has documented interactions with 7 drug classes — none of Metoproterenol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Star Of Bethlehem interact with any other medications?
Yes. Star Of Bethlehem has 156 documented drug interactions in our database — Metoproterenol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metoproterenol interact with any supplements?
Yes. Metoproterenol has documented interactions with 15 supplements in our database — Star Of Bethlehem is not one of them. The Metoproterenol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Star Of Bethlehem monograph Uses, safety profile, and every drug interaction in one place Metaproterenol drug information The full plain-English guide to this medication Metoproterenol supplement interactions Every supplement checked against Metoproterenol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metoproterenol and Star Of Bethlehem?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.