Drug & supplement interaction

Star Of Bethlehem + Doripenem

Doripenem brand name: Doribax.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Doripenem falls into 2 drug categories that Star Of Bethlehem can interact with; the most serious is rated moderate. Theoretically, taking macrolide antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Star Of Bethlehem and Doripenem

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Star Of Bethlehem interacts with whole categories of medication. Doripenem falls into 2 of those categories, so it can interact with Star Of Bethlehem in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

MACROLIDE ANTIBIOTICS

1 of 2

Why this applies to Doripenem

Doripenem falls under MACROLIDE ANTIBIOTICS — the group Star Of Bethlehem interacts with.

Theoretically, taking macrolide antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides. Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to understand about this pairing. Star of Bethlehem naturally contains cardiac glycosides, which are heart-active compounds similar to digoxin. The concern on file is that some antibiotics can boost how much of those glycosides your gut absorbs, which could, in theory, push you toward heart-rhythm problems, nausea, or feeling unusually tired or dizzy.

A couple of honest points, though. This warning was built around macrolide antibiotics (like erythromycin), and Doripenem (Doribax) is actually a carbapenem, a different class, so it may not behave the same way. On top of that, this is a purely theoretical interaction, not something proven in people. And most flower-essence products are so diluted they contain little to no actual plant chemical. Still, since Doripenem treats serious infections, please run any star of Bethlehem product by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
  3. Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.
Moderate

TETRACYCLINE ANTIBIOTICS

2 of 2

Doripenem also falls under TETRACYCLINE ANTIBIOTICS.

Theoretically, taking tetracycline antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides similar to digitalis. Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for doripenem (Doribax). Star of Bethlehem naturally contains heart-acting compounds called cardiac glycosides, similar to digitalis. The concern on file is that certain antibiotics may boost how much of these glycosides your gut absorbs, which could raise the odds of glycoside-type side effects like an irregular or slow heartbeat, nausea, or feeling dizzy. Doripenem itself is not a prodrug, so it stays an active antibiotic either way.

Honestly, this is a theoretical flag based on how tetracyclines behave, and doripenem is a carbapenem given by IV, not a tetracycline taken by mouth, so the overlap is shaky. Most flower-essence products are also so diluted they contain almost no plant chemicals. Still, please mention any supplement to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
  3. Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Star Of Bethlehem Also Interacts With Other Medications

Star Of Bethlehem has 155 moderate known drug interactions in our database — the Doripenem one above is among them. If you take anything else, check it against the full list below.

Moderate 155 No known interaction 2,675 (incl. Doripenem)
Taking anything else?

Check Another of Your Medications Against Star Of Bethlehem

Covers the 2,830 medications we’ve checked against Star Of Bethlehem. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Doripenem

This page covers Star Of Bethlehem only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doripenem page lists 84 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Oleander (major), Para-aminobenzoic Acid (paba) (major), Acerola (moderate), Alpha-lipoic Acid (moderate) and Bacillus Coagulans (moderate).

By severity: 2 major · 75 moderate · 7 minor.

From our pharmacist’s overview on the Doripenem page

“Two entries here matter more than all the others, and I would read them first. Doripenem (Doribax) is an intravenous antibiotic reserved for serious bacterial infections, which means anything that weakens treatment or piles on risk deserves genuine caution.”

Reviewed by 2 · Jul 18, 2026

Open the Doripenem interaction page

One more smart check

Taking Star Of Bethlehem as Part of a Dietary Supplement Product? Check It for Interactions

We hold 15 real supplement products containing Star Of Bethlehem, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Star Of Bethlehem. Your product may carry other ingredients that interact with Doripenem too, on top of Star Of Bethlehem — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Star Of Bethlehem and Doripenem Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Star Of Bethlehem
Top half

#600 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doripenem
Steady interest

#2,446 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Star Of Bethlehem

What is Star Of Bethlehem?

  • Emotional shock and trauma
  • Grief and bereavement
  • Stress relief
  • Calming and comfort

Star of Bethlehem is a small flowering plant best known as one of the ingredients in Bach flower remedies, where it is used for emotional shock and grief. There is no solid scientific evidence that it treats any medical condition, and the raw plant and bulb are considered toxic, so it should not be eaten. If you choose to use a flower-essence product, treat it as a complement to—not a replacement for—proper medical care.

Read the full Star Of Bethlehem monograph & all interactions
Medication

About Doripenem Injection

What Is Doripenem Injection Used For?

Brand name: Doribax

  • Doripenem injection is used to treat serious infections of the urinary tract, kidney, and abdomen that are caused by bacteria. Doripenem injection is not approved by the Food and Drug Administration (FDA) to treat pneumonia that developed in people who were on a ventilator in a hospital. Doripenem injection is in a class of medications called carbapenem antibiotics. It works by killing bacteria.

  • Antibiotics such as doripenem injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See full Doripenem Injection drug information
Keep checking

Other Drugs & Star Of Bethlehem

Browse every other medication we’ve checked against Star Of Bethlehem — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
155Moderate
0Minor
2,674No known interaction
155 Moderate 2,674 No interaction
Moderate

155 interactions

Showing 60 of 155 moderate interactions — see all 155 on the Star Of Bethlehem page.

No interaction 2,674 drugs checked — show the list

We also checked Star Of Bethlehem against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,674 medications checked with no known interaction — see the full Star Of Bethlehem list.

See the full Star Of Bethlehem interactions page
See every supplement checked against Doripenem, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Star Of Bethlehem monograph › Uses, safety, and every drug interaction in one place Doripenem supplement interactions › Every supplement checked against Doripenem, ranked by severity Doripenem Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Star Of Bethlehem and Doripenem Together: Common Questions

Can you take Star Of Bethlehem with Doripenem?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Star Of Bethlehem and Doripenem?
Doripenem belongs to more than one drug category, and Star Of Bethlehem interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Star Of Bethlehem and Doripenem interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Doripenem and Star Of Bethlehem?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.