Medication interaction hub

What Supplements Interact with Prazepam?

Prazepam brand name: Centrax. Every interaction below applies to the brands too.

99 Interactions 8 Major 76 Moderate 15 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Prazepam? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Prazepam against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Prazepam (Centrax) is a benzodiazepine prescribed for anxiety, and any drug that calms the brain this directly leaves little margin for supplements that do the same. I'd treat this list with genuine respect. Seventy-eight of the 99 entries can deepen its sedation, and the eight rated major, alcohol and kava among them, can push drowsiness toward dangerously slowed breathing. Grapefruit also sits in the major group because it can raise blood levels of some benzodiazepines and magnify their effects.

The rest of the list is less dramatic but worth knowing. Seventeen ingredients, mostly fibers and charcoals, can change how much of an oral dose gets absorbed, so keep those well separated from the medication. A few others may blunt prazepam's calming effect instead, caffeine-containing herbs included. Seventy-six entries rate moderate and 15 minor, but the pairing to settle first is the simplest one, beer or wine alongside a benzodiazepine.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 76 Minor 15 No known interaction 1,353

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Prazepam: Top Interactions at a Glance

The most significant Prazepam supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 99 interacting ingredients — plus 1,353 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Prazepam + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Prazepami

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Prazepami

Grapefruit juice might increase blood levels of some oral benzodiazepines, potentially increasing the effects and adverse effects of these drugs.

Read the full interaction Major Likelihood Likely Wine + Prazepami

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Prazepami

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Prazepami

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Prazepami

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction
The complete list

Every Supplement Checked Against Prazepam

All 1,452 ingredients in our database, ranked by severity — 99 with a Prazepam interaction on file and 1,353 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Prazepam?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Delta-9-tetrahydrocannabinol (thc) with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Prazepam answer

Can you take Elecampane with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Prazepam answer

Can you take European Barberry with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Prazepam answer

Can you take Galphimia Glauca with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Prazepam answer

Can you take Gamma Butyrolactone (gbl) with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Prazepam answer

Can you take German Chamomile with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Prazepam answer

Can you take Goldenseal with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the sedative effects of CNS depressants.

Full Goldenseal + Prazepam answer

Can you take Gotu Kola with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Prazepam answer

Can you take Griffonia Simplicifolia with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Full Griffonia Simplicifolia + Prazepam answer

Can you take Guar Gum with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Prazepam answer

Can you take Guarumo with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle...

Full Guarumo + Prazepam answer

Can you take Gum Arabic with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Prazepam answer

Can you take Hesperidin with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with CNS depressants may cause additive sedative effects.

Full Hesperidin + Prazepam answer

Can you take Hops with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Full Hops + Prazepam answer

Can you take Indian Snakeroot with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Indian snakeroot might cause additive sedative effects.

Full Indian Snakeroot + Prazepam answer

Can you take Jackfruit with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.

Full Jackfruit + Prazepam answer

Can you take Jamaican Dogwood with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Jamaican dogwood may potentiate sedative effects.

Full Jamaican Dogwood + Prazepam answer

Can you take Kratom with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.

Full Kratom + Prazepam answer

Can you take Lemon Balm with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Full Lemon Balm + Prazepam answer

Can you take Lemon Verbena with Prazepam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lemon verbena with benzodiazepines might increase the risk of sedation and respiratory depression.

Full Lemon Verbena + Prazepam answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Prazepam is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Prazepam, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Prazepam sits in 3 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Prazepam through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Prazepam through this category.

Benzodiazepines 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Prazepam through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Prazepam

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Prazepam.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Prazepam-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Prazepam.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Prazepam & Supplements: Common Questions

What supplements interact with Prazepam?
Our database currently documents 99 ingredients with a known Prazepam interaction (8 major, 76 moderate, 15 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 99. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Prazepam supplement interactions are the most serious?
The 8 major-rated combinations — led by Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Prazepam?
Plenty of supplements coexist fine with Prazepam; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Centrax have the same supplement interactions as Prazepam?
Yes — Centrax all contain Prazepam, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Prazepam and my other medications?
This page covers Prazepam against supplements and herbal ingredients. Checking Prazepam against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.