Medication interaction hub

What Supplements Interact with Procaine (prescription drug)?

Procaine (prescription drug) brand name: Novocain. Every interaction below applies to the brands too.

11 Interactions 1 Major 10 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 21, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Procaine (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Procaine (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Procaine (Novocain) is the numbing injection used at the dentist and before minor procedures, and its interaction list warrants real caution, not panic. Six of the 11 ingredients on file, including everyday products like melatonin and ginkgo, may make seizures more likely, since anesthetics such as procaine already lower the seizure threshold, the point at which the brain can misfire. The other five affect anesthesia itself, and the lone major-rated entry sits in that group: fever bark, whose reserpine content has been linked to unstable heart function during general anesthesia.

The other ten entries rate moderate, though moderate still covers serious ground; one adds suppressed breathing on top of the anesthetic's own effect, which can be fatal. Because you rarely pick the timing of a procaine shot, tell the dentist or doctor everything you take beforehand, fever bark above all.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 10 No known interaction 1,441

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Procaine (prescription drug): Top Interactions at a Glance

The most significant Procaine (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 11 highest-ranked of 11 interacting ingredients — plus 1,441 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Procaine (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Fever Bark + Procaine (prescription drug)i

Theoretically, fever bark might increase the risk of cardiovascular instability with general anesthesia.

Read the full interaction
The complete list

Every Supplement Checked Against Procaine (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 11 with a Procaine (prescription drug) interaction on file and 1,441 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Procaine (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabis with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabis use might alter the safety and clinical effects of various forms of anesthesia.

Full Cannabis + Procaine (prescription drug) answer

Can you take Cowhage with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.

Full Cowhage + Procaine (prescription drug) answer

Can you take Datura Wrightii with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Datura wrightii causes respiratory depression.

Full Datura Wrightii + Procaine (prescription drug) answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. THC use might alter the safety and clinical effects of various forms of anesthesia.

Full Delta-9-tetrahydrocannabinol (thc) + Procaine (prescription drug) answer

Can you take Dendrobium with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Procaine (prescription drug) answer

Can you take Ginkgo with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Procaine (prescription drug) answer

Can you take Melatonin with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Procaine (prescription drug) answer

Can you take Rauwolscine with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Procaine (prescription drug) answer

Can you take Thuja with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Procaine (prescription drug) answer

Can you take Fever Bark with Procaine (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, fever bark might increase the risk of cardiovascular instability with general anesthesia.

Full Fever Bark + Procaine (prescription drug) answer

Can you take Biofeedback with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Procaine (prescription drug) answer

Can you take Cannabis with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabis use might alter the safety and clinical effects of various forms of anesthesia.

Full Cannabis + Procaine (prescription drug) answer

Can you take Cowhage with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.

Full Cowhage + Procaine (prescription drug) answer

Can you take Datura Wrightii with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Datura wrightii causes respiratory depression.

Full Datura Wrightii + Procaine (prescription drug) answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. THC use might alter the safety and clinical effects of various forms of anesthesia.

Full Delta-9-tetrahydrocannabinol (thc) + Procaine (prescription drug) answer

Can you take Dendrobium with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Procaine (prescription drug) answer

Can you take Ginkgo with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Procaine (prescription drug) answer

Can you take Melatonin with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Procaine (prescription drug) answer

Can you take Rauwolscine with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Procaine (prescription drug) answer

Can you take Thuja with Procaine (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Procaine (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Procaine (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Procaine (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Procaine (prescription drug) sits in 2 interaction categories. Open any one to see what the group means:

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Procaine (prescription drug) through this category.

Anesthesia 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Procaine (prescription drug) through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Procaine (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Procaine (prescription drug).

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Pharmacist Counseling Corner

Procaine (prescription drug) & Supplements: Common Questions

What supplements interact with Procaine (prescription drug)?
Our database currently documents 11 ingredients with a known Procaine (prescription drug) interaction (1 major, 10 moderate, 0 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 11. The highest-ranked right now: Fever Bark, Biofeedback, Cannabis.
Which Procaine (prescription drug) supplement interactions are the most serious?
Focus on the major group: Fever Bark. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Procaine (prescription drug)?
Plenty of supplements coexist fine with Procaine (prescription drug); a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Novocain have the same supplement interactions as Procaine (prescription drug)?
Yes — Novocain all contain Procaine (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Procaine (prescription drug) and my other medications?
This page covers Procaine (prescription drug) against supplements and herbal ingredients. Checking Procaine (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 21, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.