Medication interaction hub

What Supplements Interact with Propofol?

Propofol brand name: Diprivan. Every interaction below applies to the brands too.

11 Interactions 1 Major 10 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Propofol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Propofol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

11 supplements and herbal ingredients have interactions with Propofol on file in the HelloPharmacist interaction database — 1 rated major, 10 moderate, and 0 minor. The most serious involve Fever Bark.

Our assessment: with 1 major-rated interaction on the list, this one deserves real attention — know the major entries before combining anything with Propofol.

Major 1 Moderate 10 No known interaction 1,441

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Propofol: Top Interactions at a Glance

The most significant Propofol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 11 highest-ranked of 11 interacting ingredients — plus 1,441 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Propofol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Fever Bark + Propofoli

Theoretically, fever bark might increase the risk of cardiovascular instability with general anesthesia.

Read the full interaction
The complete list

Every Supplement Checked Against Propofol

All 1,452 ingredients in our database, ranked by severity — 11 with a Propofol interaction on file and 1,441 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Propofol?

One-line answers, one card per combination — scroll through today’s 16 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Datura Wrightii with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Datura wrightii causes respiratory depression.

Full Datura Wrightii + Propofol answer

Can you take Dendrobium with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Propofol answer

Can you take Ginkgo with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Propofol answer

Can you take Melatonin with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Propofol answer

Can you take Rauwolscine with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Propofol answer

Can you take Thuja with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Propofol answer

Can you take Fever Bark with Propofol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, fever bark might increase the risk of cardiovascular instability with general anesthesia.

Full Fever Bark + Propofol answer

Can you take Biofeedback with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Propofol answer

Can you take Cannabis with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabis use might alter the safety and clinical effects of various forms of anesthesia.

Full Cannabis + Propofol answer

Can you take Cowhage with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.

Full Cowhage + Propofol answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. THC use might alter the safety and clinical effects of various forms of anesthesia.

Full Delta-9-tetrahydrocannabinol (thc) + Propofol answer

Can you take Dendrobium with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Propofol answer

Can you take Ginkgo with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Propofol answer

Can you take Melatonin with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Propofol answer

Can you take Rauwolscine with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Propofol answer

Can you take Thuja with Propofol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Propofol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Propofol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Propofol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Propofol sits in 2 interaction categories. Open any one to see what the group means:

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Propofol through this category.

Anesthesia 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Propofol through this category.

Related: does Propofol deplete any nutrients?

Propofol has 1 reported nutrient association in the research literature — see the Propofol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Propofol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Propofol.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Propofol & Supplements: Common Questions

What supplements interact with Propofol?
Our database currently documents 11 ingredients with a known Propofol interaction (1 major, 10 moderate, 0 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 11. The highest-ranked right now: Fever Bark, Biofeedback, Cannabis.
Which Propofol supplement interactions are the most serious?
Focus on the major group: Fever Bark. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Propofol?
Plenty of supplements coexist fine with Propofol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Diprivan have the same supplement interactions as Propofol?
Yes — Diprivan all contain Propofol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Propofol deplete any vitamins or nutrients?
It might — Propofol has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Propofol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Propofol and my other medications?
This page covers Propofol against supplements and herbal ingredients. Checking Propofol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.