3in1 Mushroom Complex Ingredients & Drug Interactions
What is this page for?
First and foremost: checking 3in1 Mushroom Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
3in1 Mushroom Complex is a dietary supplement by Nutrifect Nutrition with 3 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 502 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom, Lion's Mane, Cordyceps sinensis extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against 3in1 Mushroom Complex by Nutrifect Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with 3in1 Mushroom Complex by Nutrifect Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of 3in1 Mushroom Complex by Nutrifect Nutrition
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 3 of its 3 active ingredients.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 3 of the 3 matched ingredients can interact with medications — Cordyceps, Reishi Mushroom, Lion's Mane Mushroom.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
- For scale: 502 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 2 of 3.
- General safety write-ups exist for 3 of 3.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 3in1 Mushroom Complex, straight from the product label.
| Brand | Nutrifect Nutrition |
|---|---|
| Barcode (UPC) | 0667486465428 |
| Net contents | 90 Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 228318 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 3in1 Mushroom Complex by Nutrifect Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Reishi Mushroom | 500 mg | -- |
| Cordyceps sinensis extract | 500 mg | -- |
| Lion's Mane | 500 mg | -- |
Other ingredients: Rice Flour, Gelatin, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement take three (3) capsules once a day. For best results take 20-30 min before a meal with an 8 fl oz glass of water or as directed by your healthcare professional.
Precautions
Caution: Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Caution: Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children.
Do not use if safety seal is damaged or missing.
Storage
Store in a cool, dry place.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
3in1 Mushroom Complex by Nutrifect Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 3in1 Mushroom Complex by Nutrifect Nutrition
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Reishi Mushroom
Interacts with375 drugs
Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...
Reishi Mushroom monograph & interactionsCordyceps sinensis extract
Interacts with249 drugs
Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...
Cordyceps sinensis extract monograph & interactionsLion's Mane
Interacts with327 drugs
Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...
Lion's Mane monograph & interactionsOther (inactive) ingredients: Rice Flour, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
3in1 Mushroom Complex by Nutrifect Nutrition Drug Interactions
3in1 Mushroom Complex contains 3 ingredients, and 3 of them have known drug interactions. Altogether they interact with 502 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against 3in1 Mushroom Complex?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in 3in1 Mushroom Complex interact with 502 drugs. Click any drug to see the details.
3 of the 3 ingredients in 3in1 Mushroom Complex interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom Lion's Mane Cordyceps sinensis extract
Aspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Caffeine, Orphenadrine interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Caffeine, Orphenadrine interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Carisoprodol interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Carisoprodol interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Carisoprodol, Codeine Phosphate interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Carisoprodol, Codeine Phosphate interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Citric Acid, Sodium Bicarbonate interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Citric Acid, Sodium Bicarbonate interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Codeine Phosphate interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Codeine Phosphate interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Codeine Phosphate, Methocarbamol interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Codeine Phosphate, Phenobarbital interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Codeine Phosphate, Phenobarbital interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Diphenhydramine, Phenylpropanolamine interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Dipyridamole interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Dipyridamole interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Ethoheptazine, Meprobamate interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Ethoheptazine, Meprobamate interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Hydrocodone interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Hydrocodone interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Meprobamate interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Meprobamate interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Methocarbamol interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Methocarbamol interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Omeprazole interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Omeprazole interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Oxycodone interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Oxycodone interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with 3in1 Mushroom Complex — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Aspirin, Pentazocine interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Aspirin, Pentazocine interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Pentazocine interactionAtenololAtenix, Tenormin
How Atenolol interacts with 3in1 Mushroom Complex — through 1 ingredient. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with 3in1 Mushroom Complex — through 1 ingredient. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with 3in1 Mushroom Complex — through 1 ingredient. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Atenolol, Chlorthalidone interactionAtezolizumabTecentriq
How Atezolizumab interacts with 3in1 Mushroom Complex — through 2 ingredients. Tap an ingredient for the detail:
Lion's ManeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane + Atezolizumab interactionCordyceps Sinensis ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with 3in1 Mushroom Complex — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + Azamune interactionLion's ManeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with 3in1 Mushroom Complex — through 2 ingredients. Tap an ingredient for the detail:
Lion's ManeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane + Azathioprine interactionCordyceps Sinensis ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + Azathioprine interactionAzilsartanEdarbi
How Azilsartan interacts with 3in1 Mushroom Complex — through 1 ingredient. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with 3in1 Mushroom Complex — through 1 ingredient. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Azilsartan, Chlorthalidone interactionBasiliximabSimulect
How Basiliximab interacts with 3in1 Mushroom Complex — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + Basiliximab interactionLion's ManeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane + Basiliximab interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with 3in1 Mushroom Complex — through 2 ingredients. Tap an ingredient for the detail:
Lion's ManeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane + Beclometasone Dipropionate interactionCordyceps Sinensis ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + Beclometasone Dipropionate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in 3in1 Mushroom Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Reishi Mushroom
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
Lion's Mane
Anticoagulant/Antiplatelet Drugs
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.
Immunosuppressants
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.
Cordyceps sinensis extract
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for 3in1 Mushroom Complex, from the product label.
Nutrifect Nutrition
See all Nutrifect Nutrition products- Name
- Nutrifect Nutrition
- Street Address
- 1001 Millersville Rd
- City
- Lancaster
- State
- PA
- ZipCode
- 17603
- Phone Number
- (855) 280-8129
3in1 Mushroom Complex by Nutrifect Nutrition: Common Questions
Does 3in1 Mushroom Complex by Nutrifect Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 3in1 Mushroom Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Reishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph → Herb & supplement monographCordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph → Herb & supplement monographLion's Mane Mushroom
Interacts with 327 drugsLion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...
Read the full Lion's Mane Mushroom monograph →Sources & How We Checked
3in1 Mushroom Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Reishi Mushroom 17 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
- Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
- Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
- Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
- Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
- Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
- Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
- Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
- Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
- Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
- Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
- Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
- Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
- Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
- Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
- Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
- Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
- Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
- Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
- Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
- Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
- Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
- Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
- Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
- Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
- Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
- Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
- Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.
Lion's Mane Mushroom 6 references
- Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
- Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
- Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
- Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
- Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
- Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.
See these in context on the Lion's Mane Mushroom monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC