5-HTP 50 mg Ingredients & Drug Interactions
by Klaire Labs
What is this page for?
First and foremost: checking 5-HTP 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
5-HTP 50 mg is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for low mood or depression, anxiety and stress, sleep problems.Based on those ingredients, 398 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-5-Hydroxytryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against 5-HTP 50 mg by Klaire Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with 5-HTP 50 mg by Klaire Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of 5-HTP 50 mg by Klaire Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-5-Hydroxytryptophan (5-HTP), an amino acid that your body uses to produce serotonin, a chemical messenger in the brain. The remaining ingredients are inactive — microcrystalline cellulose, vegetarian capsule material, L-leucine, and silicon dioxide — they're there to hold the capsule together and help with absorption.
Does it work?
Moderate evidence
The evidence for 5-HTP in depression is possibly effective, meaning some studies suggest it may help but the data isn't yet conclusive. For other conditions listed in the research — Alzheimer's disease and panic disorder — we don't have enough reliable evidence to say whether it works.
Down syndrome shows possibly ineffective. If you're thinking about 5-HTP for a specific condition, talk with your doctor or pharmacist about whether the evidence is strong enough for your situation.
How safe is it?
Well-documented data
Orally, 5-HTP is generally well tolerated in the short term. The most common side effects are abdominal pain, nausea, vomiting, diarrhea, dizziness, drowsiness, fatigue, headache, insomnia, and loss of appetite — most seem to depend on the dose and how fast you increase it.
Some people find these ease with time. Rare serious effects include aggression, hallucinations, and mania, particularly at high doses or when combined with carbidopa.
There isn't enough safety information to use 5-HTP during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether the potential benefit outweighs the unknown risks for your situation.
Meds to double-check
Moderate interaction found
Before you take this, double-check any serotonergic drugs you're on — antidepressants, mood stabilizers, and migraine or pain medications like tramadol (Moderate risk). Also flag CNS depressants like sedatives or sleep aids (Moderate).
If you take carbidopa for Parkinson's disease, mention this supplement to your doctor (Moderate). Use the tool below to search your complete medication list.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
5-HTP may help with depression, but it works through serotonin, so it needs careful pairing with other medications — especially antidepressants and sedating drugs. If you take any prescription medication or have a history of mood disorders, check with your pharmacist before starting.
The side effects are usually mild and dose-dependent, but they're worth watching for.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 5-HTP 50 mg, straight from the product label.
| Brand | Klaire Labs |
|---|---|
| Barcode (UPC) | 828054011205 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 280424 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 5-HTP 50 mg by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-5-Hydroxytryptophan | 50 mg | -- |
Other ingredients: Microcrystalline, Vegetarian Capsule, L-Leucine, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.
This product contains a natural source of L-5-Hydroxytryptophan (5-HTP) extracted from the seeds of the Griffonia plant and is certified to be free of Peak X.
Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule, 1 to 2 times daily or as directed by a healthcare professional.
Formula
This product contains a natural source of L-5-Hydroxytryptophan (5-HTP) extracted from the seeds of the Griffonia plant and is certified to be free of Peak X.
Precautions
Do not use if shrinkwrap is broken or missing.
Caution: May cause drowsiness. Exercise caution if operating a motor vehicle or machinery.
If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product.
Keep out of reach of children.
Storage
Store in a cool, dry place (59 degrees F - 85 degrees F) away from direct light.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
SFI
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
5-HTP 50 mg by Klaire Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 5-HTP 50 mg by Klaire Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
L-5-Hydroxytryptophan
Interacts with398 drugs
5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...
L-5-Hydroxytryptophan monograph & interactionsOther (inactive) ingredients: Microcrystalline, Vegetarian Capsule, L-Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
5-HTP 50 mg by Klaire Labs Drug Interactions
HelloPharmacist Interaction Report
Klaire Labs 5-HTP can interact with several medication types.
The most serious concern is with serotonergic drugs — that's medications that increase serotonin (like antidepressants, some migraine treatments, and tramadol). Combining them with 5-HTP carries a Moderate risk of additive serotonergic effects, including serotonin syndrome and related conditions.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check if you take CNS depressants (sedating medications like benzodiazepines or sleep aids). 5-HTP can cause drowsiness on its own, and adding these drugs might pile on that effect.
Carbidopa (Lodosyn), used for Parkinson's disease, is another Moderate concern — it's sometimes paired with 5-HTP intentionally, but the combination raises the risk of restlessness, anxiety, insomnia, and mood changes like hypomania.
Altogether, these interactions span 398 individual medications. Use the medication checker below to search your exact prescriptions and over-the-counter drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against 5-HTP 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in 5-HTP 50 mg interact with 398 drugs. Click any drug to see the details.
1 of the 1 ingredient in 5-HTP 50 mg interact with drugs. Each result below shows which ingredient is responsible. L-5-Hydroxytryptophan
AcepromazineAtravet
How Acepromazine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acepromazine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with 5-HTP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in 5-HTP 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-5-Hydroxytryptophan
Carbidopa (Lodosyn)
Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.
Cns Depressants
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.
Serotonergic Drugs
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.
Brand information
Manufacturer and brand details for 5-HTP 50 mg, from the product label.
Klaire Labs
See all Klaire Labs products- Name
- SFI USA
- City
- Reno
- State
- NV
- ZipCode
- 89521
- Web Address
- Klaire.com
5-HTP 50 mg by Klaire Labs: Common Questions
Does 5-HTP 50 mg by Klaire Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take 5-HTP if I'm on an antidepressant?
What are the most common side effects?
Is it safe to take 5-HTP while pregnant or breastfeeding?
Will 5-HTP actually help my depression?
Does this product have fillers or added ingredients?
Can I take it with sedating medications like sleep aids?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if 5-HTP 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 5-HTP 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
5-HTP 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
5-htp 32 references
- Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
- Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
- Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
- U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
- Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
- Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
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