Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

3 Stress Relief Ingredients & Drug Interactions

by Renew Life

3 Stress Relief label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 3 Stress Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

3 Stress Relief is a dietary supplement by Renew Life with 3 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,351 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are 5-HTP, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 3 Stress Relief by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with 3 Stress Relief by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 3 Stress Relief by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Vitamin B6” is listed as a grouped ingredient — the label gives one combined amount (5 mg) without saying how much of each component you get.

3 Stress Relief contains 8 ingredients, including kava kava extract, lemon balm, hops extract, skullcap extract, meadowsweet extract, 5-HTP, chamomile extract, and Vitamin B6 (listed as a blend component). The product also includes a Proprietary Botanical Blend whose specific contents aren't disclosed.

The capsule itself is made from vegetable material. Kava, lemon balm, hops, and skullcap are all traditional herbal ingredients used for relaxation.

5-HTP is an amino acid precursor to serotonin, a brain chemical involved in mood. Meadowsweet is an herb historically used for various complaints.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: stress relief and relaxation.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Insomnia, Depression, Menopausal symptoms, Nervous tension — and 3 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Depression (Natural Medicines).
  • Also on file: 5-htp is rated "Possibly Effective" for Depression.
  • Also on file: Kava is rated "Possibly Ineffective" for Generalized anxiety disorder (GAD).

The evidence supporting these ingredients is mixed. Lemon balm is rated possibly effective for stress and for cold sores, and possibly effective for depression.

5-HTP is rated possibly effective for depression. For the other active ingredients—kava (for anxiety), hops (for anxiety, insomnia, and cognitive decline), skullcap (for stress), and meadowsweet (for headache and respiratory infections)—the evidence isn't established in our data; we hold insufficient reliable evidence to rate them.

The Proprietary Botanical Blend's effectiveness cannot be assessed because its ingredients aren't listed.

The evidence, ingredient by ingredient Vitamin B6 Kava German Chamomile Hops Lemon Balm Meadowsweet Skullcap 5-htp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, most of these ingredients are generally well tolerated short-term, but several carry important cautions. Kava has been linked to over 100 cases of liver injury worldwide, most with excessive and prolonged use, and the safety notes advise caution because it poses a rare but serious liver risk.

Common side effects from the ingredients include drowsiness, dizziness, dry mouth, headache, nausea, and gastrointestinal upset. 5-HTP can cause nausea, diarrhea, abdominal pain, and dizziness; at higher doses or when increased quickly, these may be more likely.

Skullcap may cause sedation, cognitive impairment, and digestive disturbances. Hops may cause drowsiness.

Lemon balm may cause dizziness and sedation, though these don't appear to occur more often than with placebo. One rare case linked a product containing lemon balm to heart rhythm changes, though it's unclear if lemon balm was responsible.

None of these ingredients are considered safe during pregnancy and should be avoided. Kava and hops should be avoided while breastfeeding due to lack of safety data.

Lemon balm and skullcap safety during breastfeeding is unknown, so caution is advised. No pregnancy or breastfeeding data are on file for meadowsweet, 5-HTP, or the other ingredients.

Side effects, ingredient by ingredient Vitamin B6 Kava German Chamomile Hops Lemon Balm Meadowsweet Skullcap 5-htp

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Meadowsweet, Lemon Balm, 5-htp, Hops, Kava, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; Parkinson's medications.
  • For scale: 1,240 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist or doctor if you're on CNS depressants (Major severity)—that includes sedatives, sleep aids, anti-anxiety medication, opioid painkillers, or alcohol. You should also check if you take serotonergic drugs like antidepressants or migraine medications (Moderate severity), thyroid hormone (Moderate), salicylate pain relievers like aspirin (Moderate), or medications metabolized by liver enzymes including many common drugs (Moderate).

If you take carbidopa or haloperidol, or ropinirole, mention those too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take any CNS depressants (sleep aids, anxiety medications, pain relievers with opioids, or drink alcohol), or if you take thyroid medication, antidepressants, or salicylate pain relievers, talk to your pharmacist or doctor before starting this product. This supplement is not for use during pregnancy or breastfeeding.

The kava content carries a documented liver-injury risk, especially with long-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 3 Stress Relief, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257906311
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 65032
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 3 Stress Relief by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
631257906311
IngredientAmount% DV
Vitamin B65 mg250%
Proprietary Botanical Blend350 mg--
Kava Kava extract0 NP--
Chamomile extract0 NP--
Hops extract0 NP--
Lemon Balm0 NP--
Meadowsweet extract0 NP--
Skullcap extract0 NP--
5-HTP10 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

#15583 010114

Precautions

WARNING: Do not use this product if you are pregnant or nursing. Consult your physician before using this or any product if you are trying to conceive, taking medication, have a medical condition, have or have had liver problems, frequently consume alcoholic beverages, are allergic to salicylates or sensitive to any of the ingredients.

Consult your physician before using this or any product if you are trying to conceive, taking medication, have a medical condition, have or have had liver problems, frequently consume alcoholic beverages, are allergic to salicylates or sensitive to any of the ingredients.

Discontinue use if adverse effects occur.

Not for use by persons under 18 years of age.

Not for prolonged use. Do not exceed recommended dose. Do not take with alcohol. Notice: This product may cause drowsiness and should not be used while driving or operating heavy equipment.

This product is contraindicated with MAO inhibitors and Parkinson’s medications.

TAMPER EVIDENT: DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING.

KEEP OUT OF REACH OF CHILDREN.

Formulation

Contains no GMOs, yeast, wheat, soy, gluten, sugar, salt, dairy, animal products, binders, fillers or artificial ingredients

Storage

Store in a dry place at 59-86(0) F (15-30(0) C).

General Statements

Quality and Purity Guaranteed

MADE IN USA

30-Day Program

Manufactured in a GMP facility.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Renew Life The Digestive Care Experts

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule in the evening or as directed by a healthcare professional. Please read accompanying literature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

3 Stress Relief by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

3 Stress Relief label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 3 Stress Relief by Renew Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
5 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Proprietary Botanical Blend

350 mg per serving

5-HTP

Interacts with
398 drugs
10 mg per serving

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

5-HTP monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

3 Stress Relief by Renew Life Drug Interactions

Want to check YOUR meds against 3 Stress Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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1,351Drugs
248 Major 1,089 Moderate 14 Minor

Ingredients driving the most interactions

5-HTP 398
Vitamin B6 210

Individual Drug Interactions

The ingredients in 3 Stress Relief interact with 1,351 drugs. Click any drug to see the details.

2 of the 3 ingredients in 3 Stress Relief interact with drugs. Each result below shows which ingredient is responsible. 5-HTP Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in 3 Stress Relief with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

5-HTP3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
5-HTP full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 3 Stress Relief, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

3 Stress Relief by Renew Life: Common Questions

Does 3 Stress Relief by Renew Life interact with any medications?
Yes. Based on its ingredients, 3 Stress Relief has a known interaction with 1,351 medications, including 248 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
3 Stress Relief contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for stress?
Lemon balm in it is rated possibly effective for stress. The other herbal ingredients—kava, hops, and skullcap—don't have enough reliable evidence for us to say whether they work. 5-HTP is possibly effective for depression. Individual results vary, and you'd want to give it a fair trial and see how you feel.
What are the main side effects I should watch for?
Drowsiness, dizziness, headache, nausea, and stomach upset are the most common. Because kava is in here, there's also a documented but rare risk of liver injury, especially if you use it long-term. If you notice yellowing skin or eyes, dark urine, or persistent nausea while taking it, stop and contact your doctor right away.
Can I take this while pregnant or breastfeeding?
No—all the herbal ingredients in here are advised against during pregnancy. For breastfeeding, kava and hops should be avoided, and lemon balm and skullcap haven't been studied enough to say they're safe. Talk to your OB or pediatrician if you're thinking about it.
Why do I need to check with my pharmacist before taking this?
Several ingredients in this product can interact with common medications—particularly sleep aids, anxiety drugs, pain relievers, antidepressants, and heart or thyroid medications. These interactions can make your drugs less effective or increase side effects. Your pharmacist can check your specific medications against this product.
What's 5-HTP and why is it in here?
5-HTP is an amino acid your body uses to make serotonin, a brain chemical that affects mood. It's rated possibly effective for depression. It can cause nausea and digestive upset, especially at higher doses or when you increase the dose quickly, so starting low and going slow is common practice.
Is kava safe to use long-term?
Kava has been used traditionally, but it's been linked to over 100 cases of liver injury, mostly with heavy, long-term use. It's banned or restricted in some countries because of this liver risk. If you're thinking of using it regularly, talk to your doctor first and have your liver checked periodically.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 3 Stress Relief is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

3 Stress Relief label
Go deeper

The Full Monographs Behind 3 Stress Relief’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Kava

Interacts with 1,166 drugs

Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety. However, kava has been linked to rare but serious...

Read the full Kava monograph → Herb & supplement monograph

German Chamomile

Interacts with 960 drugs

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...

Read the full German Chamomile monograph → Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Meadowsweet

Interacts with 39 drugs

Meadowsweet is a traditional European herb that contains natural salicylates (aspirin-like compounds) and is used mainly for digestive upset, colds, and minor aches. High-quality human studi...

Read the full Meadowsweet monograph → Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph → Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph →
Sources

Sources & How We Checked

3 Stress Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 183 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Kava 71 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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See these in context on the 5-htp monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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