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Dietary supplement

5-HTP Natural Griffonia Seed Extract Ingredients & Drug Interactions

by Wonder Laboratories

5-HTP Natural Griffonia Seed Extract label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 5-HTP Natural Griffonia Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

5-HTP Natural Griffonia Seed Extract is a dietary supplement by Wonder Laboratories with 3 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 716 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-5-Hydroxytryptophan, Vitamin B6, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 5-HTP Natural Griffonia Seed Extract by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with 5-HTP Natural Griffonia Seed Extract by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 5-HTP Natural Griffonia Seed Extract by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients: vitamin B6 (pyridoxine), vitamin C (ascorbic acid), and L-5-hydroxytryptophan (5-HTP), which is derived from Griffonia seed extract. The inactive ingredients are vegetable cellulose, gelatin, silica, and vegetable magnesium stearate—standard capsule fillers and binders.

Vitamin B6 is an essential nutrient involved in nerve and brain function. Vitamin C supports immune health and acts as an antioxidant.

5-HTP is a compound your body uses to make serotonin, a neurotransmitter that influences mood and sleep.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: mood and appetite regulation via serotonin.
  • We looked for evidence on: Anxiety, Depression, appetite control, sleep quality, migraine.
  • The strongest evidence on file: 5-htp is rated "Possibly Effective" for Depression (Natural Medicines).
  • Also on file: 5-htp is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Migraine headache.
  • Also on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Depression, Postpartum depression.

Vitamin B6 is effective for treating sideroblastic anemia (a blood disorder) and vitamin B6 deficiency itself, and is effective for a rare seizure disorder called pyridoxine-dependent epilepsy. It's likely effective for elevated homocysteine levels and possibly effective for pregnancy-related nausea and vomiting.

Vitamin C is effective for vitamin C deficiency and possibly effective for chronic anemia, atrial fibrillation, cataracts, and respiratory infections triggered by heavy exercise. For 5-HTP, the evidence shows it's possibly effective for depression, possibly ineffective for Down syndrome, and insufficient data exists to rate its use for Alzheimer disease, panic disorder, or cerebellar ataxia.

The evidence, ingredient by ingredient Vitamin B6 Vitamin C 5-htp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily. At normal dietary and supplement amounts, it's considered safe; however, high doses over a long period can damage nerves (a condition called sensory neuropathy).

Common side effects at any dose include abdominal pain, headache, heartburn, nausea, and vomiting. Use only at recommended levels, and during pregnancy only under a doctor's guidance.

Vitamin C is generally well tolerated orally at normal doses. High doses above 2 grams daily are more likely to cause abdominal cramping, diarrhea, heartburn, headache, nausea, or kidney stones in those prone to them.

Normal amounts in food and prenatal vitamins are fine, but avoid high-dose supplements in pregnancy unless your doctor advises it. 5-HTP is generally well tolerated short-term orally.

Common side effects include abdominal pain, diarrhea, dizziness, drowsiness, fatigue, headache, insomnia, nausea, and vomiting—often dose-dependent. Rare serious effects include aggression, hallucinations, and mania.

There is not enough safety information for pregnancy or breastfeeding; avoid it during these times.

Side effects, ingredient by ingredient Vitamin B6 Vitamin C 5-htp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — 5-htp, Vitamin B6, Vitamin C.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; Parkinson's medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist if you're on seizure medications (phenobarbital, phenytoin), blood thinners (warfarin), heart rhythm drugs (amiodarone), blood pressure medications, antidepressants or other serotonin-boosting drugs (SSRIs, SNRIs, or similar), estrogen-based birth control or hormone therapy, Parkinson's medication (levodopa or carbidopa), thyroid medication (levothyroxine), HIV medications (indinavir), chemotherapy, antipsychotics, or any medication that causes sedation. These are all Moderate severity interactions, and the specifics depend on your exact drugs and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines three nutrients with overlapping but distinct roles. It's worth considering if you're deficient in B6 or C, exploring 5-HTP for mood support under professional guidance, or managing a specific condition your doctor has suggested it for.

If you take any regular medications—especially blood pressure drugs, seizure medications, blood thinners, birth control, antidepressants, or Parkinson's medication—check them against our interaction tool before starting. Talk to your pharmacist or doctor if you have questions about how this product fits with your health.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 5-HTP Natural Griffonia Seed Extract, straight from the product label.

Brand Wonder Laboratories
Barcode (UPC) 099528540129
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214659
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 5-HTP Natural Griffonia Seed Extract by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
099528540129
IngredientAmount% DV
Vitamin B610 mg500%
Vitamin C60 mg100%
L-5-Hydroxytryptophan50 mg--

Other ingredients: Vegetable Cellulose, Gelatin, Silica, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, start with a low dose of 1 capsule taken with a meal. Increase the dose slowly (every 3-5 days) up to a maximum of 4 capsules taken daily. Total daily intake should be divided into two or more doses, with no more than 2 capsules per dose.

Formula

5-HTP is the precursor to serotonin, a mood and appetite regulating neurotransmitter produced within the body. It has been combined with Vitamin C and Vitamin B-6 an important cofactor in the conversion to serotonin.

Precursor to serotonin Hydroxytryptophan with Vitamin B-6 & Vitamin C

Ko Kosher Service

Formulation

We use a natural extract that is buffered to minimize any potential gastric discomfort.

Manufactured in an FDA registered facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Gluten free

Buffered Gentle on the stomach Easy to swallow

Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Warning: This product should not be taken by children, pregnant or lactating women.

This product should not be taken by children, pregnant or lactating women.

May cause gastrointestinal upset, diarrhea or nausea which usually disappears by reducing dosage or is minimized by taking with food. As with any supplement, if discomfort persists discontinue use. Those suffering from gut disorders such as ulcers, irritable bowel disease, Crohn's disease, celiac disease, etc., should not use 5-HTP. May cause drowsiness. Do not use while driving or operating machinery.

Keep out of reach of children.

Those using MAO-inhibitors, antidepressants and drugs containing fenfluramine should not use 5-HTP.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

General Statements

Formula 540

Made in USA

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Ko Kosher Service

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

5-HTP Natural Griffonia Seed Extract by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

5-HTP Natural Griffonia Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 5-HTP Natural Griffonia Seed Extract by Wonder Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin C

Interacts with
207 drugs
60 mg per serving Form: Calcium Ascorbate

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

L-5-Hydroxytryptophan

Interacts with
398 drugs
50 mg per serving Form: Griffonia simplicifolia

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

L-5-Hydroxytryptophan monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Gelatin, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

5-HTP Natural Griffonia Seed Extract by Wonder Laboratories Drug Interactions

Want to check YOUR meds against 5-HTP Natural Griffonia Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
716Drugs
670 Moderate 46 Minor

Ingredients driving the most interactions

L-5-Hydroxytryptophan 398
Vitamin B6 210
Vitamin C 207

Individual Drug Interactions

The ingredients in 5-HTP Natural Griffonia Seed Extract interact with 716 drugs. Click any drug to see the details.

3 of the 3 ingredients in 5-HTP Natural Griffonia Seed Extract interact with drugs. Each result below shows which ingredient is responsible. L-5-Hydroxytryptophan Vitamin B6 Vitamin C

Each ingredient & the kinds of drugs it affects

For each ingredient in 5-HTP Natural Griffonia Seed Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-5-Hydroxytryptophan3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
L-5-Hydroxytryptophan full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 5-HTP Natural Griffonia Seed Extract, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

5-HTP Natural Griffonia Seed Extract by Wonder Laboratories: Common Questions

Does 5-HTP Natural Griffonia Seed Extract by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, 5-HTP Natural Griffonia Seed Extract has a known interaction with 716 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
5-HTP Natural Griffonia Seed Extract contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
Vitamin B6 is likely safe at normal levels and has been used for pregnancy-related nausea, but only under a doctor's guidance. Vitamin C is likely safe in normal amounts and prenatal doses. However, 5-HTP has not been adequately studied in pregnancy, so the safety data advises against it. Talk with your doctor or pharmacist before taking any supplement during pregnancy.
Is this safe while breastfeeding?
Vitamin B6 is likely safe while breastfeeding at recommended amounts. Vitamin C safety during lactation is not clearly established in our data. 5-HTP has not been adequately studied in breastfeeding, so the safety data advises against it. Discuss this product with your doctor or pharmacist if you're nursing.
What are the most common side effects I might notice?
The most common side effects from these three ingredients are gastrointestinal: nausea, vomiting, abdominal pain, diarrhea, and heartburn. You might also experience headache, drowsiness, or loss of appetite. Most side effects are generally mild and often depend on the dose—taking it with food may help.
Does 5-HTP really help with mood and sleep?
5-HTP is possibly effective for depression according to the research we have on file. For other mood or sleep conditions, the evidence isn't established or is insufficient to rate. Results vary from person to person, and it works best with guidance from your healthcare provider.
Can I take this if I'm on an antidepressant?
No, not without checking with your pharmacist first. 5-HTP combined with antidepressants and other serotonin-boosting drugs carries a Moderate risk of serotonin-related side effects, including serotonin syndrome. Your pharmacist needs to review your exact medication before you start this product.
Is there anything in this capsule besides the active ingredients?
Yes. The capsule contains vegetable cellulose, gelatin, silica, and vegetable magnesium stearate—these are standard inactive binders and fillers that make the capsule work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

5-HTP Natural Griffonia Seed Extract label
Go deeper

The Full Monographs Behind 5-HTP Natural Griffonia Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph →
Sources

Sources & How We Checked

5-HTP Natural Griffonia Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 115 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
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5-htp 32 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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