Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Acetyl L-Carnitine plus Alpha-Lipoic Acid Ingredients & Drug Interactions

by Bronson

Acetyl L-Carnitine plus Alpha-Lipoic Acid label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acetyl L-Carnitine plus Alpha-Lipoic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acetyl L-Carnitine plus Alpha-Lipoic Acid is a dietary supplement by Bronson with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve pain (neuropathy), energy and fatigue.Based on those ingredients, 445 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alpha-Lipoic Acid, Acetyl L-Carnitine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson

Ask about any prescription or over-the-counter medication and we check it for interactions with Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: acetyl L-carnitine and alpha-lipoic acid. Acetyl L-carnitine is a form of carnitine, a compound your body uses to help produce energy in cells, and it may support brain and nerve function.

Alpha-lipoic acid is a fatty acid that acts as an antioxidant (a substance that protects cells from damage) in your body. The tablet also includes several inactive ingredients — fillers, binders, and coating materials like microcrystalline cellulose, stearic acid, magnesium stearate, and others — that help form and preserve the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cellular energy and antioxidant support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cancer-related fatigue, Chemotherapy-induced peripheral neuropathy, Chronic fatigue syndrome (CFS), Diabetes — and 4 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Diabetic neuropathy (Natural Medicines).
  • Also on file: Acetyl-l-carnitine is rated "Possibly Effective" for Age-related cognitive decline, Alzheimer disease, Diabetic neuropathy.
  • Also on file: Alpha-lipoic Acid is rated "Possibly Ineffective" for Diabetes, Diabetic retinopathy.

Acetyl L-carnitine is rated possibly effective for age-related cognitive decline, Alzheimer disease, alcohol use disorder, diabetic neuropathy, and depression, though the evidence isn't conclusive. Alpha-lipoic acid is rated possibly effective for diabetic neuropathy, elevated cholesterol (hyperlipidemia), and obesity.

Neither ingredient has strong, definitive proof of benefit for these uses — the evidence suggests a possible role, but larger or better-designed studies are needed.

The evidence, ingredient by ingredient Acetyl-l-carnitine Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acetyl L-carnitine is generally well tolerated short-term, but long-term safety isn't fully established. The most common side effects are agitation, dry mouth, headache, insomnia, and reduced appetite.

In people with Alzheimer disease, psychiatric changes like depression, mania, confusion, or aggression have been reported, though it's unclear if the supplement caused them or the condition itself did. A metabolite may also cause a fishy odor in urine, breath, and sweat.

Gastrointestinal upset is possible but doesn't occur more often than with placebo. When this combination is taken together, diarrhea, constipation, and indigestion may occur.

Alpha-lipoic acid is generally well tolerated in most adults, though it can lower blood sugar and should be used under medical guidance if you have diabetes. Common side effects include headache, dizziness, heartburn, nausea, and vomiting.

Rash and itching have been reported. Rarely, cases of a condition called insulin autoimmune syndrome have been reported.

During pregnancy, there isn't enough safety information — it's best avoided unless your doctor advises otherwise. While breastfeeding, safety for acetyl L-carnitine is unknown and avoiding it is the safer choice; alpha-lipoic acid also lacks reliable safety data and should be avoided while breastfeeding.

Side effects, ingredient by ingredient Acetyl-l-carnitine Alpha-lipoic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Alpha-lipoic Acid, Acetyl-l-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 445 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take serotonergic drugs like antidepressants (Moderate risk), blood thinners like warfarin or other anticoagulants (Moderate risk), thyroid hormone replacement (Moderate risk), chemotherapy drugs including alkylating agents or antitumor antibiotics (Moderate risk), or diabetes medications that lower blood sugar (Minor risk). If you take any of these, don't start without guidance.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with nerve pain, brain aging, or cholesterol, but the evidence is not strong. If you take any blood thinners, antidepressants, thyroid medication, or chemotherapy drugs, talk with your pharmacist or doctor before starting — interactions are a real concern.

It's also not recommended during pregnancy or breastfeeding due to insufficient safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acetyl L-Carnitine plus Alpha-Lipoic Acid, straight from the product label.

Brand Bronson
Barcode (UPC) 716563387020
Net contents 150 Tablet(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298818
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
150
UPC/BARCODE
716563387020
IngredientAmount% DV
Acetyl L-Carnitine500 mg--
Alpha-Lipoic Acid200 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl Methylcellulose, Polyethylene Glycol, Mineral Oil, Titanium Dioxide, FD&C Yellow #5, Carnauba Wax, Talc

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Bronson Nutrition + Since 1960

Formulation

Cellular energy Antioxidant support

High potency

Made From High Quality Ingredients

FDA Statement of Identity

Dietary Supplement

Formula

Amino acid Antioxidant

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take 1 tablet two times daily, preferably with a meal or as directed by a healthcare professional.

Precautions

Warning: Consult a healthcare professional before taking this product if you are pregnant or nursing, have a medical condition or are taking medication.

Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Lab Tested Good Manufacturing GMP Practice

General Statements

100% Money Back Guaranteed 365 Days Nutrition Questions or Comments? [email protected] Call 1-800-235-3200 Mon. - Fri. 7 AM - 6 PM MST Sat. 8 AM - 4:30 PM MST

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acetyl L-Carnitine plus Alpha-Lipoic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container150 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Acetyl L-Carnitine

Interacts with
203 drugs
500 mg per serving

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...

Acetyl L-Carnitine monograph & interactions

Alpha-Lipoic Acid

Interacts with
263 drugs
200 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl Methylcellulose, Polyethylene Glycol, Mineral Oil, Titanium Dioxide, FD&C Yellow #5, Carnauba Wax, Talc. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson Drug Interactions

Want to check YOUR meds against Acetyl L-Carnitine plus Alpha-Lipoic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
445Drugs
359 Moderate 86 Minor

Ingredients driving the most interactions

Alpha-Lipoic Acid 263
Acetyl L-Carnitine 203

Individual Drug Interactions

The ingredients in Acetyl L-Carnitine plus Alpha-Lipoic Acid interact with 445 drugs. Click any drug to see the details.

2 of the 2 ingredients in Acetyl L-Carnitine plus Alpha-Lipoic Acid interact with drugs. Each result below shows which ingredient is responsible. Alpha-Lipoic Acid Acetyl L-Carnitine

Each ingredient & the kinds of drugs it affects

For each ingredient in Acetyl L-Carnitine plus Alpha-Lipoic Acid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions

Acetyl L-Carnitine4 drug types · 203 drugs

Acenocoumarol (Sintrom)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Acetyl L-Carnitine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acetyl L-Carnitine plus Alpha-Lipoic Acid, from the product label.

Bronson

Name
Bronson Laboratories
Street Address
70 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
1-800-235-3200
Web Address
BronsonVitamins.com
Pharmacist Counseling Corner

Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson: Common Questions

Does Acetyl L-Carnitine plus Alpha-Lipoic Acid by Bronson interact with any medications?
Yes. Based on its ingredients, Acetyl L-Carnitine plus Alpha-Lipoic Acid has a known interaction with 445 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acetyl L-Carnitine plus Alpha-Lipoic Acid contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my memory or mental decline?
Acetyl L-carnitine is rated possibly effective for age-related mental decline and Alzheimer disease, which means there's some evidence it might help, but it's not proven. The evidence isn't strong enough to say it will work for you — talk to your doctor about whether it's worth trying.
Can I take this if I have diabetes?
Be careful. Alpha-lipoic acid can theoretically lower blood sugar further when combined with diabetes medications, which could cause low blood sugar. It's best used under medical guidance if you have diabetes — check with your doctor or pharmacist first.
What are the most common side effects?
From acetyl L-carnitine: agitation, dry mouth, headache, insomnia, and reduced appetite. From alpha-lipoic acid: headache, heartburn, nausea, and vomiting. When taken together, you may also notice diarrhea, constipation, or indigestion. A fishy odor in urine, breath, or sweat is also possible with acetyl L-carnitine.
Is this safe during pregnancy or while breastfeeding?
No. Alpha-lipoic acid lacks enough safety data and should be avoided during pregnancy. Acetyl L-carnitine also lacks sufficient safety data while breastfeeding and should be avoided. Talk to your doctor or pharmacist if you're pregnant or nursing before considering this product.
Can I take this with my blood thinner?
It depends on which blood thinner you take, but this is a real concern. Both ingredients may increase bleeding risk or strengthen your blood thinner's effects. Do not start without checking with your pharmacist — they can review your exact medication.
Will this interact with my antidepressant?
Possibly. Acetyl L-carnitine may increase serotonin in the brain and raise the risk of serotonin syndrome, a serious condition, when combined with serotonergic drugs like many antidepressants. Check your specific medication with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acetyl L-Carnitine plus Alpha-Lipoic Acid label
Go deeper

The Full Monographs Behind Acetyl L-Carnitine plus Alpha-Lipoic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Acetyl-l-carnitine

Interacts with 203 drugs

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...

Read the full Acetyl-l-carnitine monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

Acetyl L-Carnitine plus Alpha-Lipoic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acetyl-l-carnitine 22 references
  1. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996;47:705-11. PubMed
  2. Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992;49:1137-41. PubMed
  3. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. Neurology 1991;41:1726-32. PubMed
  4. Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychoger 1998;10:193-203. PubMed
  5. Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging 1995;16:1-4. PubMed
  6. Rai G, Wright G, Scott L, et al. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr Med Res Opin 1990;11:638-47. PubMed
  7. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  8. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003;18:61-71.. PubMed
  9. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  10. Hudson S, Tabet N. Acetyl-L-carnitine for dementia. Cochrane Database Syst Rev 2003;2:CD003158.. PubMed
  11. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  12. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Drugs R D 2002;3:223-31. PubMed
  13. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  14. Sima AAF, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Diabetes Care 2005;28:89-94.
  15. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV.Med. 2007;8(4):241-250.
  16. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. A placebo-controlled trial of acetyl-L-carnitine and a-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013 Oct;33(5):627-35.
  17. Ledinek AH, Sajko MC, Rot U. Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study. Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S86-9. PubMed
  18. Martinotti G, Andreoli S, Reina D, Di Nicola M, Ortolani I, Tedeschi D, Fanella F, Pozzi G, Iannoni E, D'Iddio S, Prof LJ. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Prog Neuropsychop PubMed
  19. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. Int J Clin Pharmacol Ther. 2015;53(11):980-6. PubMed
  20. Goodison G, Overeem K, de Monte V, Siskind D. Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. Australas Psychiatry. 2017;25(1):13-4.
  21. Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali RA, Muscatello MR. Acetyl-L-Carnitine Augmentation of Clozapine in Partial-Responder Schizophrenia: A 12-Week, Open-Label Uncontrolled Preliminary Study. Clin Neuropharmacol. 2016;39(6):277-80. PubMed
  22. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018;80(2):154-9. PubMed

See these in context on the Acetyl-l-carnitine monograph →

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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