Interactions on record — worth a quick check against your medications. Based on 5 of 10 ingredients. Check your meds →
Dietary supplement

Active-8 Ingredients & Drug Interactions

by Flower Essence Services

Active-8 label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Active-8 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Active-8 is a dietary supplement by Flower Essence Services with 10 active ingredients. Its ingredients are commonly taken for nerve pain (neuropathy), muscle and joint pain (arthritis), back pain.Based on those ingredients, 711 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Taraxacum officinale, cinnamon, Capsicum annuum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Active-8 by Flower Essence Services

Ask about any prescription or over-the-counter medication and we check it for interactions with Active-8 by Flower Essence Services — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Active-8 by Flower Essence Services

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “infusions of flowers of” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Essential Oils” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Active-8 contains 10 active ingredients, all flower and plant infusions, delivered in a liquid form with water and brandy as inactive carriers. The main ingredients we can identify are capsicum (red pepper), dandelion root and leaf, sunflower oil, cassia cinnamon, and cardamom — each included for traditional or preliminary research support.

Several other flower species are also in the blend but we hold little to no interaction data for them. The product is designed as a flower essence supplement, meaning the active ingredients are concentrated infusions rather than whole plants.

This form and these ingredients haven't been extensively studied together, so we can't say what strength of effect the combination delivers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Postherpetic neuralgia — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Diabetic neuropathy — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Cluster headache — rated "Possibly Effective" (Capsicum) (Natural Medicines).
  • On file: Nonallergic rhinitis — rated "Possibly Effective" (Capsicum) (Natural Medicines).
  • On file: Postoperative pain — rated "Possibly Effective" (Capsicum) (Natural Medicines).

The evidence for Active-8 itself is not established in our data, since we don't hold effectiveness ratings for the product as a whole. For individual ingredients: capsicum shows likely effectiveness for postherpetic neuralgia (nerve pain after shingles) and diabetic nerve pain, and possibly effective evidence for cluster headaches, back pain, and post-operative nausea.

Sunflower oil is possibly effective for high cholesterol and heart disease risk. Dandelion, cassia cinnamon, and cardamom all have insufficient reliable evidence for the conditions they're traditionally used for.

Because this is a multi-ingredient blend at unknown doses, we can't predict how effective it will be for any particular use.

The evidence, ingredient by ingredient Capsicum Sunflower Oil Dandelion Cassia Cinnamon Cardamom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Capsicum is generally well tolerated in food amounts or up to 200 mg daily, though it commonly causes burning and irritation. The most frequent side effects are belching, bloating, heartburn, gas, nausea, diarrhea, and skin flushing.

Dandelion is generally well tolerated but may cause diarrhea, heartburn, and stomach discomfort; rare allergic reactions including anaphylaxis are possible. Sunflower oil is widely safe in food amounts but can trigger allergic reactions in people sensitive to ragweed and related plants.

Cassia cinnamon is safe in food amounts but concentrated doses over time carry a small risk of liver stress from its coumarin content. Cardamom is safe in food amounts.

Overall, at the doses in this liquid supplement, common side effects would likely be mild digestive upset or burning sensations. For pregnancy, capsicum is likely to possibly safe.

Dandelion and cassia cinnamon carry insufficient data — talk with your doctor before using this product if you're pregnant or breastfeeding. Sunflower oil is likely safe during both pregnancy and breastfeeding.

Side effects, ingredient by ingredient Capsicum Sunflower Oil Dandelion Cassia Cinnamon Cardamom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Sunflower Oil, Dandelion, Capsicum, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 712 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Active-8, double-check your medications if you use anticoagulant or antiplatelet drugs (warfarin, apixaban, clopidogrel, aspirin), antidiabetes drugs, hepatotoxic medications, potassium-sparing diuretics, lithium, CYP1A2 substrates (including some heart and psychiatric drugs), glucuronidated drugs, quinolone antibiotics, theophylline, or ACE inhibitors. The most serious concerns are with dandelion and capsicum's effects on blood thinners and diabetes drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Active-8 is worth discussing with your pharmacist if you're considering it, especially if you take any blood thinners, diabetes medications, heart drugs, or antibiotics. The blend contains ingredients with documented interactions affecting nearly 700 medications.

If you're pregnant, breastfeeding, or managing a chronic condition with prescription drugs, check with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Active-8, straight from the product label.

Brand Flower Essence Services
Barcode (UPC) 782932151141
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jan 24, 2014
DSLD ID 29851
Product type Botanical
Supplement form Liquid
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Active-8 by Flower Essence Services, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Spray(s)
Maximum serving Sizes:
4 Spray(s)
UPC/BARCODE
782932151141
IngredientAmount% DV
infusions of flowers of0 NP--
Rubus armeniacus0 NP--
Capsicum annuum0 NP--
Penstemon rostriflorus0 NP--
Delphinium nudicaule0 NP--
Helianthus annuus0 NP--
Madia elegans0 NP--
Taraxacum officinale0 NP--
Mentzelia laevicaulis0 NP--
Essential Oils0 NP--
cinnamon0 NP--
cardamom0 NP--

Other ingredients: Water, Brandy

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

BEST BY 06/2022 120606

Eight flowers to empower positive Purpose & Passion

Formula

flower essence & essential oil

FDA Statement of Identity

herbal supplement

Suggested/Recommended/Usage/Directions

Suggested use: Spray four times daily in mouth or around body. Shake well before use.

Formulation

Certified organic by Stellar Certification Services, Inc.

Brand IP Statement(s)

Certified Biodynamic(R) by the Demeter Association, Inc.

Seals/Symbols

DEMETER(R)

FES Quintessentials(TM)

General

120606

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Active-8 by Flower Essence Services label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Active-8 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Active-8 by Flower Essence Services

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Spray(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Infusions of flowers of

0 NP per serving

Essential Oils

0 NP per serving

Other (inactive) ingredients: Water, Brandy. These complete the product’s ingredient list but are not active constituents.

Interaction report

Active-8 by Flower Essence Services Drug Interactions

Want to check YOUR meds against Active-8?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
711Drugs
689 Moderate 22 Minor

Ingredients driving the most interactions

Taraxacum officinale 457
cinnamon 442
Capsicum annuum 239
Helianthus annuus 86

Individual Drug Interactions

The ingredients in Active-8 interact with 711 drugs. Click any drug to see the details.

4 of the 10 ingredients in Active-8 interact with drugs. Each result below shows which ingredient is responsible. Taraxacum officinale cinnamon Capsicum annuum Helianthus annuus

Each ingredient & the kinds of drugs it affects

For each ingredient in Active-8 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Taraxacum officinale7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Taraxacum officinale full monograph & interactions

cinnamon2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
cinnamon full monograph & interactions

Capsicum annuum6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Capsicum annuum full monograph & interactions

Helianthus annuus1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
A diet using sunflower oil as a fat source can cause increased fasting blood glucose levels in patients with type 2 diabetes. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Helianthus annuus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Active-8, from the product label.

Flower Essence Services

See all Flower Essence Services products
Phone Number
800-548-0075
Pharmacist Counseling Corner

Active-8 by Flower Essence Services: Common Questions

Does Active-8 by Flower Essence Services interact with any medications?
Yes. Based on its ingredients, Active-8 has a known interaction with 711 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Active-8 contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is this product actually for?
Active-8 is a flower essence supplement. Our data doesn't include effectiveness ratings for the product itself or for what condition it's intended to treat, so we can't tell you whether it works for a specific use. If you're considering it for a particular reason, check the product label or ask your pharmacist.
Can I take this if I'm on blood thinners?
Not without checking with your pharmacist first. Dandelion and capsicum in this product interact with anticoagulant and antiplatelet drugs like warfarin or clopidogrel, and both can increase bleeding risk. Your doctor or pharmacist may need to adjust your dose or monitor you more closely.
What if I have diabetes?
Talk to your pharmacist before starting. Capsicum, dandelion, sunflower oil, and cassia cinnamon all may lower blood sugar or interact with diabetes medications, and your dose might need adjustment to prevent low blood sugar (hypoglycemia).
Is this safe while breastfeeding?
Sunflower oil is likely safe, and capsicum in food amounts is likely safe. However, we don't have enough data on dandelion or cassia cinnamon during breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What are the most common side effects?
Capsicum commonly causes burning and irritation, belching, bloating, heartburn, gas, and nausea. Dandelion may cause diarrhea, heartburn, and stomach discomfort. Digestive upset is the main concern with this product.
What's in the bottle besides the active ingredients?
Water and brandy are the inactive carriers that make up the liquid. There are no fillers or binders beyond those.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Active-8 label
Go deeper

The Full Monographs Behind Active-8’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Sunflower Oil

Interacts with 86 drugs

Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a food it is generally regarded as safe, an...

Read the full Sunflower Oil monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Cardamom

Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements...

Read the full Cardamom monograph →
Sources

Sources & How We Checked

Active-8's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 140 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Capsicum 89 references
  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. Cooper RL, Cooper MM. Red pepper-induced dermatitis in breast-fed infants. Dermatol 1996;93:61-2. PubMed
  3. Millqvist E. Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms. Allergy 2000;55:546-50. DOI
  4. Locock RA. Capsicum. Can Pharm J 1985;118:517-9.
  5. Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004;328:991. PubMed
  6. Schmulson MJ, Valdovinos MA, Milke P. Chili pepper and rectal hyperalgesia in irritable bowel syndrome. Am J Gastroenterol 2003;98:1214-5. PubMed
  7. Surh YJ, Lee SS. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol 1996;34:313-6. PubMed
  8. Bouraoui A, Brazier JL, Zouaghi H, Rousseau M. Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit. Eur J Drug Metab Pharmacokinet 1995;20:173-8.
  9. Hogaboam CM, Wallace JL. Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons. Eur J Pharmacol 1991;202:129-31. PubMed
  10. Wang JP, Hsu MF, Teng CM. Antiplatelet effect of capsaicin. Thromb Res 1984;36:497-507. PubMed
  11. Williams SR, Clark RF, Dunford JV. Contact dermatitis associated with capsaicin: Hunan hand syndrome. Ann Emerg Med 1995;25:713-5. PubMed
  12. Zollman TM, Bragg RM, Harrison DA. Clinical effects of oleoresin capsicum (pepper spray) on the human cornea and conjunctiva. Ophthalmology 2000;107:2186-9. PubMed
  13. Bortolotti M, Coccia G, Grossi G, Miglioli M. The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther 2002;16:1075-82. PubMed
  14. Hakas JF Jr. Topical capsaicin induces cough in patient receiving ACE inhibitor. Ann Allergy 1990;65:322-3.
  15. Rapoport AM, Bigal ME, Tepper SJ, Sheftell FD. Intranasal medications for the treatment of migraine and cluster headache. CNS Drugs 2004;18:671-85. PubMed
  16. Stjarne P, Rinder J, Heden-Blomquist E, et al. Capsaicin desensitization of the nasal mucosa reduces symptoms upon allergen challenge in patients with allergic rhinitis. Acta Otolaryngol 1998;118:235-9. PubMed
  17. Levy RL. Intranasal capsaicin for acute abortive treatment of migraine without aura. Headache 1995;35:277.
  18. Fusco BM, Marabini S, Maggi CA, et al. Preventative effect of repeated nasal applications of capsaicin in cluster headache. Pain 1994;59:321-5. PubMed
  19. Sicuteri F, Fusco BM, Marabini S, et al. Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 1989;5:49-53. PubMed
  20. Marabini S, Ciabatti PG, Polli G, et al. Beneficial effects of intranasal applications of capsaicin in patients with vasomotor rhinitis. Eur Arch Otorhinolaryngol 1991;248:191-4. PubMed
  21. Frerick H, Keitel W, Kuhn U, et al. Topical treatment of chronic low back pain with a capsicum plaster. Pain 2003;106:59-64. PubMed
  22. Keitel W, Frerick H, Kuhn U, et al. Capsicum pain plaster in chronic non-specific low back pain. Arzneimittelforschung 2001;51:896-903. PubMed
  23. Shalansky S, Lynd L, Richardson K, et al. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. Pharmacotherapy. 2007;27:1237-47. PubMed
  24. Sumano-López H, Gutiérrez-Olvera L, Aguilera-Jiménez R, et al. Administration of ciprofloxacin and capsaicin in rats to achieve higher maximal serum concentrations. Arzneimittelforschung. 2007;57(5):286-90. PubMed
  25. Wanwimolruk S, Nyika S, Kepple M, et al. Effects of capsaicin on the pharmacokinetics of antipyrine, theophylline and quinine in rats. J Pharm Pharmacol. 1993;45(7):618-21. PubMed
  26. Cruz L, Castañeda-Hernández G, Navarrete A. Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral asprin administration in the rat. Can J Physiol Pharmacol.
  27. Rodriguez-Stanley, S., Collings, K. L., Robinson, M., Owen, W., and Miner, P. B., Jr. The effects of capsaicin on reflux, gastric emptying and dyspepsia. Aliment.Pharmacol.Ther. 2000;14(1):129-134. PubMed
  28. Brown, L., Takeuchi, D., and Challoner, K. Corneal abrasions associated with pepper spray exposure. Am.J.Emerg.Med. 2000;18(3):271-272. PubMed
  29. Vesaluoma, M., Muller, L., Gallar, J., Lambiase, A., Moilanen, J., Hack, T., Belmonte, C., and Tervo, T. Effects of oleoresin capsicum pepper spray on human corneal morphology and sensitivity. Invest Ophthalmol.Vis.Sci. 2000;41(8):2138-2147.
  30. Stam, C., Bonnet, M. S., and van Haselen, R. A. The efficacy and safety of a homeopathic gel in the treatment of acute low back pain: a multi-centre, randomised, double-blind comparative clinical trial. Br Homeopath J 2001;90(1):21-28. PubMed
  31. Olajos, E. J. and Salem, H. Riot control agents: pharmacology, toxicology, biochemistry and chemistry. J.Appl.Toxicol. 2001;21(5):355-391. PubMed
  32. Fett, D. D. Botanical briefs: Capsicum peppers. Cutis 2003;72(1):21-23.
  33. McCarthy, G. M. and McCarty, D. J. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J.Rheumatol. 1992;19(4):604-607.
  34. Chaiyata, P., Puttadechakum, S., and Komindr, S. Effect of chili pepper (Capsicum frutescens) ingestion on plasma glucose response and metabolic rate in Thai women. J.Med.Assoc.Thai. 2003;86(9):854-860.
  35. Petruzzi, M., Lauritano, D., De Benedittis, M., Baldoni, M., and Serpico, R. Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. J.Oral Pathol.Med. 2004;33(2):111-114. PubMed
  36. Misra, M. N., Pullani, A. J., and Mohamed, Z. U. Prevention of PONV by acustimulation with capsicum plaster is comparable to ondansetron after middle ear surgery: [La prevention des NVPO par acustimulation avec un emplatre de Capsicum est comparable a ce PubMed
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Sunflower Oil 2 references
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Cassia Cinnamon 20 references
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Cardamom 2 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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