No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

AFP-Peptizyde with DPP IV Activity Ingredients & Drug Interactions

by Houston Enzymes

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

AFP-Peptizyde with DPP IV Activity is a dietary supplement by Houston Enzymes with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of AFP-Peptizyde with DPP IV Activity by Houston Enzymes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Peptidase” is listed as a grouped ingredient — the label gives one combined amount (50,000 HUT) without saying how much of each component you get.

This product contains 3 active ingredients: two proteolytic enzymes (Protease 4.5 and Protease 6), a peptidase blend, and Dipeptidyl Peptidase-IV. These are all digestive enzymes meant to help break down proteins in your food.

The inactive ingredients are a vegetable capsule and rice bran.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestion of food proteins including gluten.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't hold effectiveness ratings for any of the active ingredients in this product, so the evidence for how well it works isn't established in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The protease enzymes are generally well tolerated by most adults, though some people report digestive upset or allergic reactions. Rarely, people exposed to airborne proteolytic enzymes occupationally have developed allergic rhinoconjunctivitis or asthma.

During pregnancy, safety hasn't been established, so it's best avoided unless your doctor prescribes it. Breastfeeding safety data is limited, so medical advice is recommended before use.

We don't have safety information on file for Dipeptidyl Peptidase-IV.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. However, we don't hold interaction data for Dipeptidyl Peptidase-IV, so if you're on any prescription medications—especially blood thinners or diabetes drugs—ask your pharmacist to review this product with your medication list.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This is an enzyme supplement designed to support protein digestion. If you have a history of allergies to enzyme products or occupational exposure concerns, talk with your pharmacist.

Pregnant or breastfeeding women should check with their doctor or pharmacist first. Before starting, run your medications through our interaction checker, even though no interactions are documented for the proteases we could assess.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AFP-Peptizyde with DPP IV Activity, straight from the product label.

Brand Houston Enzymes
Barcode (UPC) 898631000298
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33804
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AFP-Peptizyde with DPP IV Activity by Houston Enzymes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
898631000298
IngredientAmount% DV
Protease 4.525000 HUT--
Protease 625000 HUT--
Peptidase50000 HUT--
Dipeptidyl Peptidase-IV1200 DPPU--

Other ingredients: Vegetable Capsule, Rice Bran

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

AFP-Peptizyde from HOUSTON ENZYMES

AFP-Peptizyde (Advanced Formula Protease) may be helpful for the digestion of food proteins (including gluten, casein, and soy). AFP-Peptizyde is high in DPP IV (dipeptidyl peptidse IV) activity, which aids in the breakdown of casomorphin (from casein) and gluteomorphin (from gluten).

AFP-Peptizyde was developed by Dr. Devin Houston, PhD enzyme biochemist.

Multi-Enzyme Product for Digestion of Food Proteins including gluten, casein, and soy Advanced Formula Protease

HIGHEST QUALITY ENZYMES SUPPORT DIGESTION

General

ITEM NO. HN004-R90

Formulation

AFP-Peptizyde (Advanced Formula Protease) is papain-free and bromelain-free.

VEGETARIAN AND VEGAN FORMULA

No added sugar, starch, dairy, soy, wheat, yeast, gluten, artificial flavors, or animal derivatives.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: One (1) capsule prior to meals. More capsules may be taken as desired. Capsules may be opened and contents mixed with food or beverage.

Precautions

Do not use if tamper-proof seal is broken.

Storage

Keep container closed and store at room temperature or in freezer, but do not place in refrigerator due to humid conditions.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

The AUTHORITY on Enzymes.(TM)

Seals/Symbols

HNI

DR. HOUSTON'S HIGHEST QUALITY PLANT ENZYMES

FDA Statement of Identity

Dietary Supplement

See for yourself

AFP-Peptizyde with DPP IV Activity by Houston Enzymes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in AFP-Peptizyde with DPP IV Activity by Houston Enzymes

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease 4.5

No known
interactions
25000 HUT per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 4.5 monograph & interactions

Protease 6

No known
interactions
25000 HUT per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 6 monograph & interactions

Peptidase

50000 HUT per serving Form: Dipeptidyl Peptidase-IV
  • › Dipeptidyl Peptidase-IV

Other (inactive) ingredients: Vegetable Capsule, Rice Bran. These complete the product’s ingredient list but are not active constituents.

Interaction report

AFP-Peptizyde with DPP IV Activity by Houston Enzymes Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in AFP-Peptizyde with DPP IV Activity. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for AFP-Peptizyde with DPP IV Activity, from the product label.

Houston Enzymes

See all Houston Enzymes products
Name
Houston Nutraceuticals, Inc. (HNI)
Street Address
116 N. Broadway St.
City
Siloam Springs
State
AR
ZipCode
72761
Phone Number
866-757-8627
Web Address
www.houston-enzymes.com
Pharmacist Counseling Corner

AFP-Peptizyde with DPP IV Activity by Houston Enzymes: Common Questions

Does AFP-Peptizyde with DPP IV Activity by Houston Enzymes interact with any medications?
We do not currently list a known interaction for the mapped ingredients in AFP-Peptizyde with DPP IV Activity. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
AFP-Peptizyde with DPP IV Activity contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
Safety hasn't been established during pregnancy for the protease enzymes in this product, so it's best avoided unless your doctor prescribes it. For Dipeptidyl Peptidase-IV, we don't have pregnancy safety data on file. Talk with your doctor or pharmacist about whether this is right for you.
Is it safe to breastfeed while taking this?
There's limited safety data during breastfeeding for the proteases in this product, so it's not recommended without medical advice. We also don't have breastfeeding safety information for Dipeptidyl Peptidase-IV. Check with your doctor or pharmacist before use.
What are proteolytic enzymes supposed to do?
They're digestive enzymes designed to break down proteins in your food, helping your digestion work more efficiently.
Can I have an allergic reaction to this?
Yes. Although allergic reactions are rare, some people report digestive upset or allergic reactions to proteolytic enzymes. In uncommon cases, occupational exposure to airborne proteolytic enzymes has led to allergic rhinoconjunctivitis (nasal and eye inflammation from allergies) or asthma. If you have enzyme allergies or respiratory sensitivities, mention this to your pharmacist.
What's in the capsule besides the active ingredients?
The capsule itself is made from vegetable cellulose, and the product also contains rice bran as an inactive ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AFP-Peptizyde with DPP IV Activity is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AFP-Peptizyde with DPP IV Activity label
Go deeper

The Full Monographs Behind AFP-Peptizyde with DPP IV Activity’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

AFP-Peptizyde with DPP IV Activity's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring