TriEnza Chewable Ingredients & Drug Interactions
What is this page for?
First and foremost: checking TriEnza Chewable against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
TriEnza Chewable is a dietary supplement by Houston Enzymes with 13 active ingredients. Its ingredients are commonly taken for tooth decay prevention, dry mouth, sugar substitute.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of TriEnza Chewable by Houston Enzymes
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
TriEnza Chewable contains 13 active ingredients, most of them digestive enzymes. Xylitol is a sugar alcohol and sweetener.
Lactase helps break down milk sugar (lactose). Lipase, protease, amylase, glucoamylase, invertase, peptidase, and diastase are all enzymes that aid in breaking down different components of food—fats, proteins, starches, and sugars.
Beta-glucanase, cellulase, xylanase, and DPP IV are specialized enzymes meant to help with additional types of food breakdown. The product also contains inactive ingredients like fructose, natural flavors, and cellulose for structure and taste.
Does it work?
Strong evidence
The evidence we hold is strongest for xylitol: it's likely effective for reducing dental cavities. Lactase is effective for lactose intolerance.
For lipase, protease, and the other enzymes in this product, the evidence in our data is insufficient—we don't have reliable trials showing they work for digestive support or any specific condition. Whether they help depends on your individual situation; talk it over with your doctor or pharmacist.
How safe is it?
Well-documented data
Xylitol is generally well tolerated in food amounts but can cause digestive upset—diarrhea, gas, and bloating—at high doses (30–40 grams). It's also highly toxic to dogs, so keep it away from pets.
Lactase and lipase are generally well tolerated when used as directed. Protease may cause digestive upset or allergic reactions in some people, though serious adverse effects are rare.
A few people have reported allergic reactions to xylitol or lactase powder, though these are uncommon.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, several enzymes in this product we were unable to check, so if you take any regular medications, confirm with your pharmacist before starting.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
TriEnza is a digestive enzyme blend best suited for people who think they have trouble breaking down certain foods or for those looking to support their digestion. If you have a serious digestive condition like inflammatory bowel disease, check with your doctor first.
No drug interactions are documented, but run your medications through the checker on this page or ask your pharmacist to be sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about TriEnza Chewable, straight from the product label.
| Brand | Houston Enzymes |
|---|---|
| Barcode (UPC) | 898631000304 |
| Net contents | 180 Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jul 18, 2023 |
| DSLD ID | 295283 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for TriEnza Chewable by Houston Enzymes, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Xylitol | 1 Gram(s) | -- |
| Added Sugars | 1 Gram(s) | 2% |
| Total Sugars | 1 Gram(s) | -- |
| Lactase | 0 NP | -- |
| Lipase | 0 NP | -- |
| Protease | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Enzyme Blend | 677 mg | -- |
| Amylase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Diastase | 0 NP | -- |
| DPP IV | 0 NP | -- |
Other ingredients: Fructose, natural Lemonade flavor, natural Pomegranate flavor, Hydroxypropyl Cellulose, Magnesium Stearate, Citric Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
To report an adverse event, contact distributor: Houston Nutraceuticals, Inc. (HNI) 866-757-8627
Do not use if tamper-proof seal is broken.
Formulation
TriEnza chewable aids in the digestion of food proteins (including gluten, casein and soy), carbohydrates, sugars (including lactose), fats and polyphenols.
All vegetarian
Enzyme for digestive intolerances Supports digestion of gluten, casein, proteins, carbohydrates, lactose, polyphenols and fats Reduces occasional gas and bloating
Formula
TriEnza includes DPP IV (dipeptidyl peptidase 4) enzyme activity which, when combined with other proteases, aids in the breakdown of casomorphin (from casein) and gluteomorphin (from gluten).
Suggested/Recommended/Usage/Directions
Suggested use: Four (4) tablets at the beginning of each meal. Fewer tablets may be taken for smaller meals. Two (2) TriEnza Chewables are equivalent to one (1) TriEnza in capsule form. Use care not to inhale enzyme powder. TriEnza may be taken with other Houston Enzymes products.
Storage
Keep container closed and store at room temperature or in freezer, but do not place in refrigerator due to humid conditions.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
Houston Enzymes The Authority on Enzymes
General Statements
Dr. Houston's biochemist formulated enzymes
TriEnza was developed by Dr. Devin Houston, PhD Enzyme Biochemist
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
TriEnza Chewable by Houston Enzymes label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in TriEnza Chewable by Houston Enzymes
These are the 13 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Xylitol
No knowninteractions
Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or loz...
Xylitol monograph & interactionsOther (inactive) ingredients: Fructose, Natural Lemonade flavor, Natural Pomegranate flavor, Hydroxypropyl Cellulose, Magnesium Stearate, Citric Acid, Silica. These complete the product’s ingredient list but are not active constituents.
TriEnza Chewable by Houston Enzymes Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in TriEnza Chewable. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for TriEnza Chewable, from the product label.
Houston Enzymes
See all Houston Enzymes products- Name
- Houston Nutraceuticals, Inc. (HNI)
- Street Address
- 116 N. Broadway St.
- City
- Siloam Springs
- State
- AR
- ZipCode
- 72761
- Phone Number
- 866-757-8627
- Web Address
- www.houston-enzymes.com
TriEnza Chewable by Houston Enzymes: Common Questions
Does TriEnza Chewable by Houston Enzymes interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will TriEnza help with my lactose intolerance?
Can I take this while pregnant or breastfeeding?
What are the side effects?
Is this chewable safe if I have dogs?
Does this product have fillers or additives?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if TriEnza Chewable is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind TriEnza Chewable’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Xylitol
Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or lozenges. It is generally safe for people i...
Read the full Xylitol monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
TriEnza Chewable's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Xylitol 7 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
- Okamoto K, Kagami M, Kawai M, et al. Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test. Allergol Int. 2019;68(1):130-131. PubMed
- Rabago D, Kille T, Mundt M, Obasi C. Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness. Laryngoscope Investig Otolaryngol 2020;5(4):613-620.
- Wołyniec W, Szwarc A, Kasprowicz K, et al. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 2022;13:841056. PubMed
- Bordier V, Teysseire F, Drewe J, et al. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health 2023;6(2):264-272. PubMed
- Margulis I, Cohen-Kerem R, Stein N, et al. Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study. Int J Pediatr Otorhinolaryngol 2024;176:111818. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC