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Dietary supplement

African Mango Ingredients & Drug Interactions

by FruitrientsX

African Mango label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking African Mango against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

African Mango is a dietary supplement by FruitrientsX with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Irvingia Gabonensis Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against African Mango by FruitrientsX

Ask about any prescription or over-the-counter medication and we check it for interactions with African Mango by FruitrientsX — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of African Mango by FruitrientsX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Irvingia gabonensis extract, derived from the African mango seed. It also includes tocotriene complex and a vegetable capsule as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: weight management and metabolic health support.
  • We looked for evidence on: Obesity, Diabetes, Hypercholesterolemia, Metabolic syndrome, appetite control, cholesterol management — and 1 related terms.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for Irvingia gabonensis is limited. We hold insufficient reliable evidence to rate it for diabetes, high cholesterol, obesity, or metabolic syndrome.

While some human research shows it can lower blood sugar in people already taking diabetes medications, that's not the same as proof it works as a standalone treatment for any of these conditions.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, Irvingia gabonensis is generally well tolerated in short-term studies, though long-term safety isn't well established. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One rare case of liver inflammation (acute hepatitis) has been reported after about four days of use; the person was taking 350 mg twice daily. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications with the tool on this page if you take antidiabetes drugs or testosterone products. Both have Moderate interactions documented with this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

African Mango may be worth considering if you're interested in its traditional uses, but the evidence for effectiveness isn't solid yet. If you take diabetes medications or testosterone, talk to your pharmacist or doctor before starting — the interactions need careful monitoring.

Long-term safety isn't well studied, so keep that in mind.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about African Mango, straight from the product label.

Brand FruitrientsX
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2013
DSLD ID 26753
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for African Mango by FruitrientsX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Irvingia Gabonensis Extract150 mg--

Other ingredients: Tocotriene Complex, Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Fruitrients(R) the science of fruit

Fruitrients(R) exotic fruit supplements using the best organically grown ingredients in the purest, most concentrated form possible.

Irvingia Gabonensis IGOB 131(R) proprietary extract is a registered trademark of Gateway Health Alliances, Inc. Fairfield, CA. US PATENT 7,537,790 and International patents pending.

We use clinically tested and proven Irvingia Gabonensis Extract IGOB131(R).

Copyright (C) 2013 - Ultra Laboratories

Formulation

Our formulas are 100% Additive-Free for the highest quality fruit supplements available in the highest concentrations of ONLY the active ingredients...without any added sugar!

Additive Free - Gluten Free

Vegan Formula

Organically Grown

Dietary supplement FREE of milk, soy, salt, sugar, wheat, yeast, gluten, artificial flavors or preservatives.

General Statements

In nature, the active nutritional ingredients in exotic fruits are not found in the "watery" portion of those fruits. The active nutrition is typically found in the pulp of a fruit and that is what Fruitrients exotic fruit supplements offer.

Reference: 1. Lipids in Health and Disease. 2009, 8:71.

Optimal results when combined with a Balanced Diet and Exercise Program. INDIVIDUAL RESULTS MAY VARY.

Weight Loss Support

African Mango

Irvingia Gabonensis or African Mango is primarily found in West and Central Africa. The potent seeds of the African Mango tree are reported to have many useful health benefits.

- Improve Cholesterol Helath - Promote Healthy Weight Loss - Support Blood Glucose Health

Why pay for "Sugar Water"? Most of the fruit juice products today are little more than expensive, watered-down sugary drinks. In fact, almost all fruit juices are anywhere from 85-99% water. Furthermore, the taste of some exotic fruit ingredients is unfavorable, so they are only in a relatively low concentration in juice drinks, sometimes with sugar added to mask the flavor.

Seals/Symbols

Gluten-Free Formula

V VEGAN

Fruitrients(R) the science of fruit i'm free [of additives]

NO FLOW AGENTS All Natural Additive-Free High Quality NO MAGNESIUM STEARATE

grown naturally without chemicals

Precautions

Not recommended for pregnant or lactating women. If currently using prescription medicine or you have a medical condition, consult your Doctor prior to use.

Allergy Information: Product is manufactured in a facility that processes milk, egg, soy, tree nuts, fish & shellfish.

Keep Out of Reach of Children.

Do not use if safety seal on cap or printed inner seal is missing or broken.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take one (1) capsule before each of the first two meals of the day or as directed by a Health Care Practitioner.

Storage

Store in a Cool, Dry Place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

African Mango by FruitrientsX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

African Mango label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in African Mango by FruitrientsX

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Irvingia Gabonensis Extract

Interacts with
94 drugs
150 mg per serving Form: Albumins

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

Irvingia Gabonensis Extract monograph & interactions

Other (inactive) ingredients: Tocotriene Complex, Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

African Mango by FruitrientsX Drug Interactions

Want to check YOUR meds against African Mango?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

Irvingia Gabonensis Extract 94

Individual Drug Interactions

The ingredients in African Mango interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in African Mango interact with drugs. Each result below shows which ingredient is responsible. Irvingia Gabonensis Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in African Mango with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Irvingia Gabonensis Extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
Irvingia Gabonensis Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for African Mango, from the product label.

FruitrientsX

See all FruitrientsX products
Name
Ultra Laboratories
Pharmacist Counseling Corner

African Mango by FruitrientsX: Common Questions

Does African Mango by FruitrientsX interact with any medications?
Yes. Based on its ingredients, African Mango has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
African Mango contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take African Mango if I'm on diabetes medication?
Not without talking to your doctor first. Irvingia gabonensis can lower blood sugar, and combined with your diabetes medication it could push your blood sugar too low. You'd need close monitoring and possibly a dose adjustment.
Is African Mango safe to take long-term?
The short-term studies show it's generally well tolerated, but we don't have good data on long-term safety or product quality. That's something worth discussing with your pharmacist if you're thinking about using it regularly.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against it during pregnancy and breastfeeding because there isn't enough information to know it's safe for your baby.
What side effects might I notice?
The most common ones reported are flatulence, headache, insomnia, and nausea. A single rare case of liver inflammation has been reported, so if you develop yellowing of the skin or eyes, belly pain, or unusual fatigue, stop and call your doctor right away.
Does African Mango actually work for weight loss or blood sugar?
The evidence isn't solid yet. We don't have reliable evidence to rate it for obesity, diabetes, high cholesterol, or metabolic syndrome. Some human research shows it does lower blood sugar in people already on diabetes drugs, but that's different from proof it works as a treatment on its own.
What if I take testosterone supplements — is this safe?
Animal research suggests Irvingia gabonensis raises testosterone levels, so taking it alongside testosterone products might add up to too much. Caution is advised, and you should discuss this with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if African Mango is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

African Mango label
Go deeper

The Full Monographs Behind African Mango’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

African Mango's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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