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Dietary supplement

African Mango Extract Ingredients & Drug Interactions

by Metabolic Maintenance

African Mango Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking African Mango Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

African Mango Extract is a dietary supplement by Metabolic Maintenance with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are African Mango Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against African Mango Extract by Metabolic Maintenance

Ask about any prescription or over-the-counter medication and we check it for interactions with African Mango Extract by Metabolic Maintenance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of African Mango Extract by Metabolic Maintenance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: African Mango Seed Extract, derived from Irvingia gabonensis. The capsule itself is vegetarian.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: control appetite and boost metabolism.
  • We looked for evidence on: Metabolic syndrome, Obesity, weight management, appetite suppression.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.

The evidence for African Mango Extract isn't established yet. Our data rates it as having insufficient reliable evidence for diabetes, high cholesterol, obesity, and metabolic syndrome.

That doesn't mean it doesn't work—it means the studies we have aren't strong enough to say one way or the other.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

African Mango Extract is generally well tolerated in the short term based on available research, but long-term safety and product quality haven't been well studied. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One rare case of liver inflammation (hepatitis) has been reported after supplementation, though this is uncommon. The safety data advises against use during pregnancy and breastfeeding, so if you're pregnant or nursing, skip this product.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product before you start, especially if you take antidiabetes drugs (blood sugar medications) or testosterone products. Both carry moderate interaction risk.

Use the search tool on this page with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood sugar medication or testosterone therapy, talk to your pharmacist before starting this supplement—dose adjustments may be needed, and the testosterone interaction isn't fully understood. If you're pregnant or breastfeeding, don't use it.

The evidence for its effectiveness isn't strong enough yet to say what it does.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about African Mango Extract, straight from the product label.

Brand Metabolic Maintenance
Barcode (UPC) 838287003168
Net contents 60 Capsule(s); 150 mg
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24727
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for African Mango Extract by Metabolic Maintenance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
838287003168
IngredientAmount% DV
African Mango Seed Extract150 mg--

Other ingredients: vegetarian capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

This patented African Mango Extract is clinically proven to control appetite, boost metabolism and promote metabolic balance.

316001A EXP4/14

Manufactured in a GMP Compliant Facility

WEIGHT MANAGEMENT

v.01

Formulation

Gluten and Excipient-free.

Precautions

CAUTION: Pregnant or lactating women, consult your healthcare professional before taking this product.

Storage

Keep tightly closed in a cool, dry place out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: One (1) capsule twice a day, 30 minutes before largest meals, or as directed by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

African Mango Extract by Metabolic Maintenance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

African Mango Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in African Mango Extract by Metabolic Maintenance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

African Mango Seed Extract

Interacts with
94 drugs
150 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

African Mango Seed Extract monograph & interactions

Other (inactive) ingredients: Vegetarian capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

African Mango Extract by Metabolic Maintenance Drug Interactions

Want to check YOUR meds against African Mango Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

African Mango Seed Extract 94

Individual Drug Interactions

The ingredients in African Mango Extract interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in African Mango Extract interact with drugs. Each result below shows which ingredient is responsible. African Mango Seed Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in African Mango Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

African Mango Seed Extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango Seed Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for African Mango Extract, from the product label.

Metabolic Maintenance

See all Metabolic Maintenance products
Name
Metabolic Maintenance Products
Street Address
PO Box 940
City
Sisters
State
Oregon
ZipCode
97759
Web Address
www.metabolicmaintenance.com
Pharmacist Counseling Corner

African Mango Extract by Metabolic Maintenance: Common Questions

Does African Mango Extract by Metabolic Maintenance interact with any medications?
Yes. Based on its ingredients, African Mango Extract has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
African Mango Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes?
Only with caution and medical supervision. This extract can lower blood sugar, so if you're on diabetes medication, combining them increases your risk of low blood sugar. Your doctor may need to adjust your dose. Monitor your blood glucose closely and don't start without talking to your pharmacist first.
What are the side effects?
The most common ones reported are flatulence, headache, insomnia, and nausea. These happened in short-term studies. One rare case of liver inflammation has been reported, though it's very uncommon. Long-term safety data is sparse.
Is it safe to take during pregnancy or while breastfeeding?
No. There isn't enough safety data during pregnancy, and the available information advises against it. The same goes for breastfeeding. If you're pregnant or nursing, don't use this product.
Can I take this with testosterone therapy?
Not without caution. Animal research suggests this extract may increase testosterone levels, and combined with testosterone products the effect isn't clear. If you're on testosterone therapy, you should avoid this supplement or use it only under close medical supervision.
Does this product actually help with weight loss or cholesterol?
The evidence isn't established yet. We don't have reliable studies showing it works for obesity, high cholesterol, or metabolic syndrome. That doesn't mean it's useless—it just means we don't have the data to say either way.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if African Mango Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

African Mango Extract label
Go deeper

The Full Monographs Behind African Mango Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

African Mango Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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