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Dietary supplement

African Mango Seed Ingredients & Drug Interactions

by Samsara Herbs

African Mango Seed label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking African Mango Seed against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

African Mango Seed is a dietary supplement by Samsara Herbs with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are African Mango. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against African Mango Seed by Samsara Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with African Mango Seed by Samsara Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of African Mango Seed by Samsara Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: African Mango (Irvingia gabonensis) seed powder. There are no inactive or filler ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support cholesterol and weight management.
  • We looked for evidence on: Hypercholesterolemia, Obesity, Blood sugar support, Metabolism support.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence for African Mango is not established in the data we hold. Studies have looked at whether it may help with diabetes, high cholesterol, obesity, and metabolic syndrome, but the evidence remains insufficient to rate its effectiveness for any of these uses.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

African Mango is generally well tolerated in the short term based on study experience, though long-term safety and product quality haven't been well established. The most common side effects reported are flatulence, headache, insomnia, and nausea.

One case of liver inflammation (hepatitis) has been reported in someone taking the seed extract, though this is rare. During pregnancy, the safety data advises against use.

While breastfeeding, there isn't enough reliable safety information available, so it's best avoided then too. Talk with your pharmacist or doctor if you're pregnant or nursing and considering this product.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking African Mango Seed, check with your pharmacist if you take antidiabetes drugs or testosterone products. Both have Moderate interactions documented with this ingredient.

Your blood sugar and testosterone levels should be monitored closely if you use both.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

African Mango might interest you if you're exploring options for blood sugar or weight management, but the evidence for it isn't solid yet. If you take diabetes medication or testosterone, this product needs careful attention — your blood sugar and hormone levels could shift.

Talk to your pharmacist before starting, especially if you're on any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about African Mango Seed, straight from the product label.

Brand Samsara Herbs
Barcode (UPC) X0017PW6MX
Net contents 8 Ounce(s); 227 Gram(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220243
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for African Mango Seed by Samsara Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.74 Gram(s)
Maximum serving Sizes:
2.74 Gram(s)
Servings per container
84
UPC/BARCODE
X0017PW6MX
IngredientAmount% DV
African Mango2740 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

African Mango Seed 20:1 Concentrated extract

Description African Mango Seed, also known as Dika nut, has a history of use throughout central Africa as a superfood, due to its nutrient dense composition. It has gained popularity in the west because it is believed to support cholesterol, appetite control and potential weight loss.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice USA Tested 3rd party USA tested

General Statements

About us At Samsara Herbs, we believe that all positive change in the world must first begin with positive change from within. We invite you to tap into your own infinite power through the use of our potent herbal extracts! We seek out only quality herbs from our trusted sources from around the world for use in our herbal extracts. Samsara Herbs, dedicated to empowering your life force!

Formulation

Full Spectrum herbal extracts are made by concentrating the herb into an extract form, while maintaining all of its original compounds. The ideal choice for those wanting a more potent version of a complete herbal powder.

Suggested/Recommended/Usage/Directions

Our water soluble herbal extracts are best mixed in juice or a smoothie, although mixing in water is perfectly fine if you can tolerate the taste.

Suggested Use: Take 1 Scoop 1-3 times per day or as recommended by your health care professional.

Storage

Storage Cool dry place, out of direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: If you have a medical condition, are pregnant or taking medications, consult your hearth care professional before using this product.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

African Mango Seed by Samsara Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

African Mango Seed label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in African Mango Seed by Samsara Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.74 Gram(s) Dosage formPowder Servings per container84 Amounts shown are per serving.

African Mango

Interacts with
94 drugs
2740 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

African Mango monograph & interactions
Interaction report

African Mango Seed by Samsara Herbs Drug Interactions

Want to check YOUR meds against African Mango Seed?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

African Mango 94

Individual Drug Interactions

The ingredients in African Mango Seed interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in African Mango Seed interact with drugs. Each result below shows which ingredient is responsible. African Mango

Each ingredient & the kinds of drugs it affects

For each ingredient in African Mango Seed with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

African Mango2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango full monograph & interactions
The maker

Brand information

Manufacturer and brand details for African Mango Seed, from the product label.

Samsara Herbs

See all Samsara Herbs products
Name
Aspen Copacking
Street Address
810 North 2800 West
City
Lindon
State
Utah
ZipCode
84042
Pharmacist Counseling Corner

African Mango Seed by Samsara Herbs: Common Questions

Does African Mango Seed by Samsara Herbs interact with any medications?
Yes. Based on its ingredients, African Mango Seed has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
African Mango Seed contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm diabetic and on medication?
Not without talking to your pharmacist first. African Mango can lower blood sugar, so combined with your diabetes medication it could drop too low. Your glucose levels will need close monitoring and your medication dose might need adjusting.
What side effects should I watch for?
The most common ones reported are gas, headache, trouble sleeping, and nausea. There's also one documented case of liver inflammation, though that's rare. If you develop yellowing of the skin, belly pain, or unusual tiredness, stop and see your doctor.
Is this safe to take long-term?
The data we have shows it's tolerated okay in the short term, but long-term safety and product quality haven't been well studied. That's worth discussing with your pharmacist before committing to regular use.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against use during pregnancy. While breastfeeding, there isn't enough information to know either way, so it's best avoided then too. Talk with your doctor if you're in either situation and interested in this product.
Does African Mango actually work for weight loss or cholesterol?
The evidence isn't solid enough to say. Studies have looked at it for obesity, high cholesterol, and metabolic syndrome, but the evidence remains insufficient to rate whether it actually works for any of these.
What is African Mango seed actually for?
It's been studied as a potential supplement for blood sugar control, cholesterol, weight management, and metabolic health. The research is still early and inconclusive, which is why the evidence rating is insufficient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if African Mango Seed is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

African Mango Seed label
Go deeper

The Full Monographs Behind African Mango Seed’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

African Mango Seed's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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