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Dietary supplement

African Mango Seed Extract Ingredients & Drug Interactions

by Z Natural Foods

African Mango Seed Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking African Mango Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

African Mango Seed Extract is a dietary supplement by Z Natural Foods with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are African Mango seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against African Mango Seed Extract by Z Natural Foods

Ask about any prescription or over-the-counter medication and we check it for interactions with African Mango Seed Extract by Z Natural Foods — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of African Mango Seed Extract by Z Natural Foods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains one active ingredient: African Mango seed extract (Irvingia gabonensis). The only other ingredient listed is maltodextrin, which is an inactive filler used to standardize the powder texture and help with absorption.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: weight loss and metabolic support.
  • We looked for evidence on: Obesity, Diabetes, Hypercholesterolemia, Metabolic syndrome, appetite control, glucose metabolism.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for what this extract actually does isn't established yet. The data we hold rates it as having insufficient reliable evidence for diabetes, high cholesterol, obesity, and metabolic syndrome — meaning studies so far haven't been solid enough to say whether it works for any of these.

That doesn't mean it doesn't; it means we need better research.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use appears generally well tolerated in studies, though long-term safety and product quality aren't well established. The most common side effects reported were flatulence, headache, insomnia, and nausea.

One case of acute liver inflammation (hepatitis) has been reported in someone taking 350 mg twice daily, with symptoms starting four days after starting the supplement — so it's worth watching your liver and how you feel if you use this. Avoid this during pregnancy; there isn't enough safety data.

Do not use while breastfeeding either — no reliable information exists for that either.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take antidiabetes drugs (blood sugar medications) — there's a Moderate risk of low blood sugar — or testosterone products. These are the two main categories documented to interact with this extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood sugar medication or testosterone products, talk to your pharmacist before starting this supplement — the interactions are real and may need dose adjustments. The evidence for whether it actually works isn't solid yet.

Long-term safety is unclear, so this isn't a long-term commitment without more data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about African Mango Seed Extract, straight from the product label.

Brand Z Natural Foods
Barcode (UPC) 616983441473
Net contents 1 Pound(s); 454 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319387
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for African Mango Seed Extract by Z Natural Foods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.4 Gram(s)
Maximum serving Sizes:
1.4 Gram(s)
Servings per container
324
UPC/BARCODE
616983441473
IngredientAmount% DV
African Mango seed extract1400 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non GMO Gluten free

Vegan

Raw

Chemical free

FDA Statement of Identity

Dietary Supplement

Formula

Our African Mango Seed Extract Powder comes from the seeds of the cherished African Mango fruit. African cultures have used both the mango and its seed for centuries as an important source of nutrition.

Suggested/Recommended/Usage/Directions

Suggested use: Mix 1/2 tablespoon (1.4 g) with juice or water. Drink 30 minutes before a meal.

Precautions

California Prop 65 Warning: Cancer and Reproductive Harm - www.P65Warnings.ca.gov/food

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

African Mango Seed Extract by Z Natural Foods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

African Mango Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in African Mango Seed Extract by Z Natural Foods

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.4 Gram(s) Dosage formPowder Servings per container324 Amounts shown are per serving.

African Mango seed extract

Interacts with
94 drugs
1400 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

African Mango seed extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

African Mango Seed Extract by Z Natural Foods Drug Interactions

Want to check YOUR meds against African Mango Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

African Mango seed extract 94

Individual Drug Interactions

The ingredients in African Mango Seed Extract interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in African Mango Seed Extract interact with drugs. Each result below shows which ingredient is responsible. African Mango seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in African Mango Seed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

African Mango seed extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for African Mango Seed Extract, from the product label.

Z Natural Foods

See all Z Natural Foods products
Name
Z Natural Foods
Street Address
5407 N Haverhill Rd Ste 336
City
West Palm Beach
State
FL
ZipCode
33407
Web Address
www.ZNaturalFoods.com
Pharmacist Counseling Corner

African Mango Seed Extract by Z Natural Foods: Common Questions

Does African Mango Seed Extract by Z Natural Foods interact with any medications?
Yes. Based on its ingredients, African Mango Seed Extract has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
African Mango Seed Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes?
Not without talking to your doctor or pharmacist first. Research shows this extract lowers blood sugar, which combined with your diabetes medication could make it drop too low. Your glucose levels would need close monitoring and your medication dose might need adjusting.
Is it safe to take long-term?
Short-term use appears okay in studies, but long-term safety isn't well established, and product quality can vary. We don't have good data on what happens if you take it for months or years.
What side effects might I get?
The most common are flatulence, headache, insomnia, and nausea. One case of liver inflammation was reported in someone taking 350 mg twice daily, so watch how you feel and let your doctor know if anything doesn't seem right.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided. Don't use while breastfeeding either — no reliable information exists for that.
Does it actually work for weight loss or cholesterol?
The evidence isn't solid yet. Studies so far haven't been strong enough to say whether it works for obesity, high cholesterol, or metabolic syndrome. We need better research.
What exactly is in this powder?
One active ingredient — African Mango seed extract — plus maltodextrin as a filler to make it easier to mix and absorb.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if African Mango Seed Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

African Mango Seed Extract label
Go deeper

The Full Monographs Behind African Mango Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

African Mango Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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