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Dietary supplement

African Mango Seed Extract Ingredients & Drug Interactions

by Z Natural Foods

African Mango Seed Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking African Mango Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

African Mango Seed Extract is a dietary supplement by Z Natural Foods with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are African Mango seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against African Mango Seed Extract by Z Natural Foods

Ask about any prescription or over-the-counter medication and we check it for interactions with African Mango Seed Extract by Z Natural Foods — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of African Mango Seed Extract by Z Natural Foods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient, African Mango seed extract. Our data describes it in studies of body fat reduction and blood sugar, though the facts we hold don't detail how it works.

The powder also lists maltodextrin as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Irvingia Gabonensis product and its label doesn't state a use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Our data rates African Mango seed extract as Insufficient Reliable Evidence To Rate for diabetes, hypercholesterolemia, obesity, and metabolic syndrome. In plain terms, reliable evidence isn't established enough to judge whether it works for any of these uses.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, it is generally well tolerated in studies, though long-term safety and product quality are not well established. The most common side effects were flatulence, headache, insomnia, and nausea.

Headache and insomnia also appeared in control groups. A single case of acute hepatitis (liver inflammation) has been reported in a 45-year-old man taking 350 mg twice daily for body fat reduction.

For pregnancy, our safety notes advise avoiding it because there isn't enough safety data. For breastfeeding, no reliable safety information is available.

Talk with your own doctor or pharmacist about your situation.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check antidiabetes drugs first, rated Moderate, because of the risk of low blood sugar and the need for close glucose monitoring. Testosterone products come next, also rated Moderate, due to possible additive effects.

Confirm your exact prescriptions with your own doctor or pharmacist before combining.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This powder may interest someone exploring African mango seed extract, though the evidence for its uses is not established. Anyone taking diabetes medicines or testosterone products should be especially careful, and so should anyone who is pregnant or breastfeeding.

Talk it over with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about African Mango Seed Extract, straight from the product label.

Brand Z Natural Foods
Barcode (UPC) 616983441473
Net contents 1 Pound(s); 454 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319387
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for African Mango Seed Extract by Z Natural Foods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.4 Gram(s)
Maximum serving Sizes:
1.4 Gram(s)
Servings per container
324
UPC/BARCODE
616983441473
IngredientAmount% DV
African Mango seed extract1400 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non GMO Gluten free

Vegan

Raw

Chemical free

FDA Statement of Identity

Dietary Supplement

Formula

Our African Mango Seed Extract Powder comes from the seeds of the cherished African Mango fruit. African cultures have used both the mango and its seed for centuries as an important source of nutrition.

Suggested/Recommended/Usage/Directions

Suggested use: Mix 1/2 tablespoon (1.4 g) with juice or water. Drink 30 minutes before a meal.

Precautions

California Prop 65 Warning: Cancer and Reproductive Harm - www.P65Warnings.ca.gov/food

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

African Mango Seed Extract by Z Natural Foods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

African Mango Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in African Mango Seed Extract by Z Natural Foods

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.4 Gram(s) Dosage formPowder Servings per container324 Amounts shown are per serving.

African Mango seed extract

Interacts with
94 drugs
1400 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

African Mango seed extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

African Mango Seed Extract by Z Natural Foods Drug Interactions

Want to check YOUR meds against African Mango Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

African Mango seed extract 94

Individual Drug Interactions

The ingredients in African Mango Seed Extract interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in African Mango Seed Extract interact with drugs. Each result below shows which ingredient is responsible. African Mango seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in African Mango Seed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

African Mango seed extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
African Mango seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for African Mango Seed Extract, from the product label.

Z Natural Foods

See all Z Natural Foods products
Name
Z Natural Foods
Street Address
5407 N Haverhill Rd Ste 336
City
West Palm Beach
State
FL
ZipCode
33407
Web Address
www.ZNaturalFoods.com
Pharmacist Counseling Corner

African Mango Seed Extract by Z Natural Foods: Common Questions

Does African Mango Seed Extract by Z Natural Foods interact with any medications?
Yes. Based on its ingredients, African Mango Seed Extract has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
African Mango Seed Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take it while pregnant?
Our safety notes advise avoiding it during pregnancy because there isn't enough safety data to support its use. Talk with your own doctor or pharmacist for advice on your situation.
Can I take it while breastfeeding?
No reliable safety information is available for use while breastfeeding, so there isn't enough data to know either way. Please talk with your doctor or pharmacist before using it.
Does it cause side effects?
The most common side effects were flatulence, headache, insomnia, and nausea. Headache and insomnia also appeared in control groups, and one case of acute hepatitis has been reported.
Does it work for weight loss?
Our data rates it as Insufficient Reliable Evidence To Rate for obesity. That means reliable evidence isn't established enough to say whether it helps with weight.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if African Mango Seed Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

African Mango Seed Extract label
Go deeper

The Full Monographs Behind African Mango Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

African Mango Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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