Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Afternoon Ingredients & Drug Interactions

by Cellucor

Afternoon label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Afternoon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Afternoon is a dietary supplement by Cellucor with 4 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 796 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous, Capsimax Cayenne (Capsicum annuum) fruit extract, Toothed Clubmoss (Huperzia serrata) aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Afternoon by Cellucor

Ask about any prescription or over-the-counter medication and we check it for interactions with Afternoon by Cellucor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Afternoon by Cellucor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “SuperHD Fire Fuel Blend (Combination)” is a proprietary blend — the label gives one combined amount (485 mg) without saying how much of each component you get.

Afternoon has four active ingredients. Caffeine anhydrous is the primary stimulant.

The product also contains SuperHD Fire Fuel Blend, a proprietary combination; DygloFit (from Dichrostachys glomerata fruit); and Capsimax Cayenne (a cayenne pepper fruit extract). The inactive ingredients are microcrystalline cellulose, the capsule shell, vegetable magnesium stearate, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Mental alertness and energy.
  • We looked for evidence on: Mental alertness, Athletic performance, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Memory, Narcolepsy — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Caffeine is rated "Possibly Effective" for Memory.

Caffeine is effective for neonatal apnea, postoperative headache, and likely effective for mental alertness and athletic performance. It is possibly effective for bronchopulmonary dysplasia.

Capsicum (cayenne) is likely effective for postherpetic neuralgia and diabetic neuropathy, and possibly effective for cluster headache, back pain, and postoperative nausea and vomiting. We hold no effectiveness data for toothed clubmoss or DygloFit.

The evidence, ingredient by ingredient Caffeine Capsicum Toothed Clubmoss

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate doses is generally well tolerated in healthy adults, though high amounts can cause serious side effects. Common effects include anxiety, headache, insomnia, tremors, nausea, and restlessness; stroke has been reported rarely.

The product carries a caution about pregnancy — high doses may pose risks, so talk with your doctor about what's safe for you — and a caution about breastfeeding, since small amounts pass into milk, though moderate intake is usually considered acceptable. Capsicum is generally well tolerated in food amounts or extracts up to 200 mg daily; common effects are burning, bloating, diarrhea, gas, and nausea.

Concentrated capsicum supplements are not well studied and should be avoided unless your doctor approves. Safety in pregnancy and breastfeeding for concentrated supplements is not well established.

Toothed clubmoss carries safety cautions: no serious adverse effects have been reported, but a thorough safety evaluation has not been done, and the data advises against use during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Caffeine Capsicum Toothed Clubmoss

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Toothed Clubmoss, Capsicum, Caffeine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 796 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check it against these medication types: ephedrine or other stimulants (Major severity), followed by sedatives like pentobarbital, heart medications like dipyridamole, the antipsychotic clozapine, stomach acid reducers like cimetidine, quinolone antibiotics, seizure drugs like phenobarbital and carbamazepine, blood thinners and antiplatelet drugs like warfarin and aspirin, diabetes medications, theophylline, and anticholinergic or cholinergic drugs. Use the medication checker below to see if your exact medications are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a caffeine-based energy capsule best suited for healthy adults who want mental alertness or athletic performance support and have no drug interactions. If you take any prescription medications — especially stimulants, sedatives, heart drugs, diabetes medications, seizure medications, antibiotics, or drugs that affect nerve signaling — check your exact list with the tool on this page before you start.

Talk to your pharmacist if you're pregnant, breastfeeding, or unsure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Afternoon, straight from the product label.

Brand Cellucor
Barcode (UPC) 842595100211
Net contents 112 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2018
DSLD ID 83115
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Afternoon by Cellucor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
56
UPC/BARCODE
842595100211
IngredientAmount% DV
Caffeine Anhydrous0 NP--
SuperHD Fire Fuel Blend (Combination)485 mg--
DygloFit (Dichrostachys glomerata) fruit extract0 NP--
Capsimax Cayenne (Capsicum annuum) fruit extract0 NP--
Toothed Clubmoss (Huperzia serrata) aerial parts extract0 NP--

Other ingredients: Microcrystalline Cellulose, Capsule Shell, Vegetable Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take morning serving (1 red capsule) with 8-12 fl. oz. of water early to middle of morning. Take afternoon serving (1 orange capsule) with 8-12 fl. oz. of water 4-6 hours after morning serving. Do not taking this product within 6 hours of bedtime.

Use only as directed.

Precautions

Do not take this product within 6 hours of bedtime. Use only as directed.

Total Caffeine Content: 150mg per capsule.

Warning: This product is only intended to be consumed by healthy adults, 18 years of age or older.

Do not use this product if you are pregnant or nursing. Before using this product, consult a licensed, qualified, health care professional, including but not limited to, if: you are taking antidepressants such as MAOI (Monoamine Oxidase Inhibitor) or SSRI, blood thinners, nonsteroidal anti-inflammatory drugs, pseudoephedrine, or you are taking any other dietary supplement, prescription drug or over-the-counter medication; or if, you suspect you have or have been treated for, diagnosed with or have a family history of, any medical condition, including but not limited to: high or low blood pressure, diabetes, anxiety, cardiovascular, psychiatric or seizure disorders, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, or difficulty urinating due to prostate enlargement.

The product contains caffeine and should not be used by individuals wishing to eliminate caffeine from their diet or in combination with caffeine or stimulants from other sources, including but not limited to, coffee, tea, soda, or other dietary supplements and medications.

Discontinue use 2 weeks prior to surgery. Immediately discontinue use and contact a medical doctor if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Formula

Total Caffeine Content: 150mg per capsule.

The product contains caffeine and should not be used by individuals wishing to eliminate caffeine from their diet or in combination with caffeine or stimulants from other sources, including but not limited to, coffee, tea, soda, or other dietary supplements and medications.

Fuel your afternoon with Huperzine A and caffeine to enhance your cognitive performance, endurance and energy, while keeping your body in fat loss mode with the thermogenic properties of Capsimax and clinically studied DygloFit.

With patented DygloFit

Brand IP Statement(s)

DygloFit is a trademark of Gateway Health Alliances, Inc. and is protected under U.S. Patents 8,241,682 and 8,623,432 and patents pending.

Cellucor, SuperHD, and SuperHR Fire are trademarks of and distributed by: Nutrabolt

DygloFit makes the difference DygloFit is a comprehensive, efficacious and mutli-dimensional weight loss ingredient that is exlusively licensed, patented and clinically studied. Subjects of multiple randomized, double-blind, placebo-controlled human clinical trials experienced significant reductions in weight, waist size, hip size, and body fat percentage. How DygloFit reduced body fat Patented DygloFit (U.S. Patent # 8,361,523) possesses polyphenol bioactives from the fruit of Dichrostachys glomerata which has multifunctional properties that help promote both healthy weight management and comprehensive metabolic wellness. This fruit has been revered as a culinary spice and for medicinal properties for hundreds of years in its native West Africa.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Daily 2 stage weight loss formula to match how you live. Mornings are not the same as afternoons, so we designed custom morning and afternoon formulas targeted for fat loss, sustained energy, optimized performance and well-being.

Morning & afternoon Weight loss formulation Potent thermogenic response 8 week supply

Ignite your goals Extinguish your doubt

FDA Statement of Identity

Dietary Supplement

General

104284

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Afternoon by Cellucor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Afternoon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Afternoon by Cellucor

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container56 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SuperHD Fire Fuel Blend (Combination)

485 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule Shell, Vegetable Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Afternoon by Cellucor Drug Interactions

Want to check YOUR meds against Afternoon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
796Drugs
8 Major 709 Moderate 79 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655
Capsimax Cayenne (Capsicum annuum) fruit extract 239
Toothed Clubmoss (Huperzia serrata) aerial parts extract 219

Individual Drug Interactions

The ingredients in Afternoon interact with 796 drugs. Click any drug to see the details.

3 of the 4 ingredients in Afternoon interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous Capsimax Cayenne (Capsicum annuum) fruit extract Toothed Clubmoss (Huperzia serrata) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Afternoon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

Capsimax Cayenne (Capsicum annuum) fruit extract6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Capsimax Cayenne (Capsicum annuum) fruit extract full monograph & interactions

Toothed Clubmoss (Huperzia serrata) aerial parts extract2 drug types · 219 drugs

Anticholinergic Drugs

In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine. Theoretically, concurrent use of anticholinergic drugs and toothed clubmoss might decrease the effectiveness of toothed clubmoss or the anticholinergic drug.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Cholinergic Drugs

Huperzine A, a constituent of toothed clubmoss, has demonstrated acetylcholinesterase inhibitory properties. Theoretically, concurrent use of toothed clubmoss with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Toothed Clubmoss (Huperzia serrata) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Afternoon, from the product label.

Cellucor

See all Cellucor products
Name
Nutrabolt
Street Address
3891 S. Traditions Dr.
City
Bryan
State
TX
ZipCode
77807
Phone Number
1.866.927.9686
Web Address
www.cellucor.com
Pharmacist Counseling Corner

Afternoon by Cellucor: Common Questions

Does Afternoon by Cellucor interact with any medications?
Yes. Based on its ingredients, Afternoon has a known interaction with 796 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Afternoon contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is caffeine in this product really effective for alertness?
Yes. Caffeine is likely effective for mental alertness and athletic performance based on our data. It's also effective for neonatal apnea and postoperative headache.
What are the most common side effects?
From caffeine: anxiety, dependence with regular use, diarrhea, headache, insomnia, tremors, nausea, and restlessness. From the cayenne extract: burning or bloating, diarrhea, gas, headache, and nausea. From the toothed clubmoss: dizziness, nausea, and sweating.
Can I take this if I'm pregnant?
There isn't enough data to know whether concentrated toothed clubmoss is safe in pregnancy, and the safety data advises against it. Caffeine in high doses may carry pregnancy risks — talk with your doctor about what amount, if any, is safe for you.
What is the SuperHD Fire Fuel Blend?
It's a proprietary combination listed as one of the four active ingredients, but the individual components within it are not disclosed separately in the product facts we have.
Is this safe to take while breastfeeding?
Small amounts of caffeine pass into breast milk and moderate intake is usually considered acceptable, though it can affect your baby. Safety of concentrated toothed clubmoss in breastfeeding is not well established and the data advises against it. Talk with your pharmacist about whether this product is right for you.
Why do I need to check this product against my medications?
The caffeine and cayenne extract in this product interact with a wide range of drugs — from heart medications and blood thinners to antibiotics and seizure drugs. Some interactions can reduce how well your medication works or increase side effects, so it's important to verify your exact prescriptions before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Afternoon label
Go deeper

The Full Monographs Behind Afternoon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

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Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Toothed Clubmoss

Interacts with 219 drugs

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. Some early research is promising, but the...

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Sources

Sources & How We Checked

Afternoon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 328 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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Toothed Clubmoss 3 references
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