Aloe Vera Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Aloe Vera Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Aloe Vera Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe vera Aerial Part Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Aloe Vera Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Aloe Vera Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Aloe Vera Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: aloe vera aerial part extract — the above-ground portion of the aloe plant. It's a powder form, with no inactive ingredients listed.
Does it work?
Moderate evidence
The evidence we have suggests aloe may be possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation. That means preliminary research points in a promising direction, but we don't yet have enough solid clinical data to be sure it works for these conditions.
If you're thinking of using it for one of these purposes, talk with your pharmacist or doctor about what the current evidence shows and whether it's right for your situation.
How safe is it?
Well-documented data
Topical aloe gel is generally well tolerated. Oral aloe latex, however, carries greater risk — especially at high doses or with long-term use.
The most common side effects from taking it by mouth are abdominal pain, cramps, and diarrhea. Serious but rare effects from long-term overuse include severe potassium loss (hypokalemia), muscle weakness, and heart rhythm problems (arrhythmia).
The safety data advises against taking oral aloe during pregnancy because it may stimulate the uterus and cause strong laxative effects. Avoid oral aloe while breastfeeding as well — there isn't enough safety data and its laxative effects could affect your infant.
Meds to double-check
Major interaction found
Check with your pharmacist if you take digoxin (a Major interaction), or blood thinners, diabetes drugs, water pills (diuretics), other laxatives, or warfarin — all Moderate concerns. Let your pharmacist also review any other medications you're on to check for liver enzyme interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
Aloe vera extract may help with acne, burns, diabetes, and a few other conditions, but the evidence is preliminary. If you take digoxin, blood thinners, diabetes medications, water pills, or other laxatives, you'll want to double-check this product with your pharmacist first — it can interact significantly.
Pregnant or breastfeeding? Skip oral aloe and talk with your doctor or pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Aloe Vera Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000Z9NDDN |
| Net contents | 1 Kilogram(s); 35.3 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 310633 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Aloe Vera Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Aloe vera Aerial Part Extract | 1000 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & Pure Bulk Supplements
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten, additives
Color may vary
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1000 mg (about 1/3 tsp) once daily with water, or as directed by a physician. Use topically as desired.
General Statements
Use an accurate milligram scale. Contents are sold by weight, not volume. Settling may occur.
New
Storage
Store in a dry, cool place.
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Aloe Vera Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Aloe Vera Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1000 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
Aloe vera Aerial Part Extract
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Aloe vera Aerial Part Extract monograph & interactionsAloe Vera Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Aloe Vera Extract by BulkSupplements.com can interact with several medication types, and the most serious concern is digoxin (Lanoxin), a heart rhythm drug.
Overuse of aloe latex can deplete potassium and increase the risk of digoxin toxicity — a Major severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Aloe also carries Moderate interactions with blood thinners (anticoagulants and antiplatelet drugs) — it may increase bleeding risk. It can lower blood sugar (glucose) levels, so it may add to the effect of diabetes medications and raise the risk of low blood sugar (hypoglycemia).
Aloe latex's laxative effect can cause diarrhea, which may strengthen warfarin's blood-thinning action and increase bleeding risk. It may also worsen potassium loss when taken with water pills (diuretics) or other strong laxatives, raising the risk of dangerously low potassium (hypokalemia).
Aloe extract shows a Minor interaction with certain drugs metabolized by the liver enzyme CYP1A2 — it may reduce their effectiveness.
Altogether, these interactions span 460 individual medications. Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Aloe Vera Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Aloe Vera Extract interact with 461 drugs. Click any drug to see the details.
1 of the 1 ingredient in Aloe Vera Extract interact with drugs. Each result below shows which ingredient is responsible. Aloe vera Aerial Part Extract
Glipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Aerial Part Extract + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Aerial Part Extract + Glucagon interactionGlucoseIV Glucose
How Glucose interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Aerial Part Extract + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Aerial Part Extract + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Aerial Part Extract + Glyburide, Metformin interactionGuanethidine, HydrochlorothiazideEsimil
How Guanethidine, Hydrochlorothiazide interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Guanethidine, Hydrochlorothiazide interactionHeparinHeparin
How Heparin interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Aerial Part Extract + Heparin interactionHydralazine, HydrochlorothiazideApresazide, Apresoline-Esidrix
How Hydralazine, Hydrochlorothiazide interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydralazine, Hydrochlorothiazide interactionHydralazine, Hydrochlorothiazide, ReserpineSer-Ap-Es, Unipres, Uniserp
How Hydralazine, Hydrochlorothiazide, Reserpine interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydralazine, Hydrochlorothiazide, Reserpine interactionHydrochlorothiazideAquazide, Aquazide H, Esidrix, HCTZ, Hydro, Hydro-D +3 more
How Hydrochlorothiazide interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide interactionHydrochlorothiazide, IrbesartanAvalide
How Hydrochlorothiazide, Irbesartan interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Irbesartan interactionHydrochlorothiazide, LabetalolTrandate HCT
How Hydrochlorothiazide, Labetalol interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Labetalol interactionHydrochlorothiazide, LisinoprilPrinzide, Zestoretic
How Hydrochlorothiazide, Lisinopril interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Lisinopril interactionHydrochlorothiazide, Losartan PotassiumHyzaar
How Hydrochlorothiazide, Losartan Potassium interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Losartan Potassium interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Methyldopa interactionHydrochlorothiazide, MetoprololLopressor HCT
How Hydrochlorothiazide, Metoprolol interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Metoprolol interactionHydrochlorothiazide, MoexiprilUniretic
How Hydrochlorothiazide, Moexipril interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Moexipril interactionHydrochlorothiazide, PindololViskazide
How Hydrochlorothiazide, Pindolol interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Pindolol interactionHydrochlorothiazide, PropranololInderide
How Hydrochlorothiazide, Propranolol interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Propranolol interactionHydrochlorothiazide, QuinaprilAccuretic
How Hydrochlorothiazide, Quinapril interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Quinapril interactionHydrochlorothiazide, ReserpineHydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2
How Hydrochlorothiazide, Reserpine interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Reserpine interactionHydrochlorothiazide, SpironolactoneAldactazide, Aldactide 25, Aldactide 50, Spirozine
How Hydrochlorothiazide, Spironolactone interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Spironolactone interactionHydrochlorothiazide, TimololTimolide
How Hydrochlorothiazide, Timolol interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Timolol interactionHydrochlorothiazide, TriamtereneDyazide, Maxzide, Maxzide-25, Triamzide, Triazide
How Hydrochlorothiazide, Triamterene interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Triamterene interactionHydrochlorothiazide, ValsartanDiovan HCT
How Hydrochlorothiazide, Valsartan interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrochlorothiazide, Valsartan interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Aerial Part Extract + Hydrocodone, Ibuprofen interactionHydroflumethiazideSaluron
How Hydroflumethiazide interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydroflumethiazide interactionHydroflumethiazide, ReserpineSalutensin, Salutensin-Demi
How Hydroflumethiazide, Reserpine interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Aerial Part Extract + Hydroflumethiazide, Reserpine interactionIbrutinibImbruvica
How Ibrutinib interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Aerial Part Extract + Ibrutinib interactionIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
How Ibuprofen interacts with Aloe Vera Extract — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Aerial Part ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Aerial Part Extract + Ibuprofen interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Aloe Vera Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Aloe vera Aerial Part Extract
Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Antidiabetes Drugs
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.
Diuretic Drugs
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Stimulant Laxatives
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Brand information
Manufacturer and brand details for Aloe Vera Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Aloe Vera Extract by BulkSupplements.com: Common Questions
Does Aloe Vera Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will aloe vera extract lower my blood sugar?
Can I take this if I'm on a blood thinner?
Is aloe powder the same as aloe gel?
What are the side effects of taking aloe by mouth?
Can I take this while pregnant?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Aloe Vera Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Aloe Vera Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Aloe Vera Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Aloe 41 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
- Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
- Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
- Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
- Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
- Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
- Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
- Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
- Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
- Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
- Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
- Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
- Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
- Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
- Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
- Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
- Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
- Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
- Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
- Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
- Savchak VI. Acute bullous allergic dermatitis due to local application of aloe leaves. Vestnik Dermatologii i Venerologii 1977;12:44-45.
- Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Contact Dermatitis 1984;11(1):51. PubMed
- Shoji, A. Contact dermatitis to Aloe arborescens. Contact Dermatitis 1982;8(3):164-167. PubMed
- Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Arch Dermatol. 1980;116(9):1064-1065. DOI
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
- Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med 2013;19(5):429-34.
- Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
- Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
- Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. PubMed
- Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96.
- Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
- Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
- Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. PubMed
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