Drug & supplement interaction

Aloe + Hydrochlorothiazide, Propranolol

Hydrochlorothiazide, Propranolol brand name: Inderide.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Hydrochlorothiazide, Propranolol falls into 2 drug categories that Aloe can interact with; the most serious is rated moderate. Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Aloe and Hydrochlorothiazide, Propranolol

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Aloe interacts with whole categories of medication. Hydrochlorothiazide, Propranolol falls into 2 of those categories, so it can interact with Aloe in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

DIURETIC DRUGS

1 of 2

Why this applies to Hydrochlorothiazide, Propranolol

Hydrochlorothiazide, Propranolol falls under DIURETIC DRUGS — the group Aloe interacts with.

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your Inderide combines two medicines: hydrochlorothiazide, a water pill, and propranolol, a beta blocker. The water pill side already nudges your body to lose potassium through your urine. Here's where aloe comes in. The yellow aloe latex (not the soothing skin gel) acts as a strong laxative, and losing fluid through your gut can pull potassium down too. Stacked together, they could leave your potassium lower than it should be.

Low potassium can show up as muscle cramps, weakness, tiredness, or an off feeling in your heartbeat. To be clear, this concern is theoretical and tied mainly to overusing oral aloe latex, not occasional use or skin gel. Still, if you take aloe by mouth, mention it to your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Minor

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

2 of 2

Hydrochlorothiazide, Propranolol also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Let's talk about your Inderide, which combines propranolol (a beta-blocker) with hydrochlorothiazide (a water pill). The propranolol part is partly broken down by a liver enzyme called CYP1A2. Some early lab research suggests aloe taken by mouth might speed up that enzyme, which could in theory lower propranolol levels a bit and make it work less well. If that happened, you might notice your heart rate or blood pressure creeping up.

Here's the honest part: this is only based on test-tube and animal data, so it's theoretical and rated minor. Aloe gel on your skin won't matter. Oral aloe is a different story, mainly because the latex is a strong laxative. Before starting any oral aloe, check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Aloe Also Interacts With Other Medications

Aloe has 1 major, 303 moderate, 156 minor known drug interactions in our database — the Hydrochlorothiazide, Propranolol one above is among them. If you take anything else, check it against the full list below.

Major 1 Moderate 303 Minor 156 No known interaction 2,370 (incl. Hydrochlorothiazide, Propranolol)
Taking anything else?

Check Another of Your Medications Against Aloe

Covers the 2,830 medications we’ve checked against Aloe. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Propranolol

This page covers Aloe only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Propranolol page lists 324 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 11 major · 273 moderate · 40 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Propranolol page

“Inderide combines hydrochlorothiazide, a water pill, with propranolol, a beta blocker, so a supplement that also lowers blood pressure or pulls potassium out of the body hits the drug on its own turf. That describes most of this list, and I'd approach it with genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Propranolol interaction page

One more smart check

Taking Aloe as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,978 real supplement products containing Aloe, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aloe. Your product may carry other ingredients that interact with Hydrochlorothiazide, Propranolol too, on top of Aloe — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aloe and Hydrochlorothiazide, Propranolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aloe
Top 10%

#85 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Propranolol
Steady interest

#1,698 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Aloe

What is Aloe?

Aloe
  • Minor burns and skin irritation
  • Wound healing
  • Constipation
  • Skin hydration and moisturizing
  • Digestive complaints
  • Hair and scalp care

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and is not considered safe for regular use. Talk to your pharmacist or doctor before taking aloe by mouth, and avoid oral aloe during pregnancy.

Read the full Aloe monograph & all interactions
Keep checking

Other Drugs & Aloe

Browse every other medication we’ve checked against Aloe — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
303Moderate
156Minor
2,369No known interaction
1 Major 303 Moderate 156 Minor 2,369 No interaction
Major

1 interaction

Moderate

303 interactions

Showing 60 of 303 moderate interactions — see all 303 on the Aloe page.

Minor

156 interactions

Showing 60 of 156 minor interactions — see all 156 on the Aloe page.

No interaction 2,369 drugs checked — show the list

We also checked Aloe against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,369 medications checked with no known interaction — see the full Aloe list.

See the full Aloe interactions page
See every supplement checked against Hydrochlorothiazide, Propranolol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Aloe monograph › Uses, safety, and every drug interaction in one place Hydrochlorothiazide, Propranolol supplement interactions › Every supplement checked against Hydrochlorothiazide, Propranolol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Aloe and Hydrochlorothiazide, Propranolol Together: Common Questions

Can you take Aloe with Hydrochlorothiazide, Propranolol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Aloe and Hydrochlorothiazide, Propranolol?
Hydrochlorothiazide, Propranolol belongs to more than one drug category, and Aloe interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Aloe and Hydrochlorothiazide, Propranolol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrochlorothiazide, Propranolol and Aloe?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.