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Dietary supplement

Alpha GPC 300 mg Ingredients & Drug Interactions

by Jarrow Formulas

Alpha GPC 300 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha GPC 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha GPC 300 mg is a dietary supplement by Jarrow Formulas with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha-Glycerylphosphorylcholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha GPC 300 mg by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha GPC 300 mg by Jarrow Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha GPC 300 mg by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: alpha-glycerylphosphorylcholine (alpha-GPC), a compound your body naturally makes and that's also found in some foods. Alpha-GPC is included in supplements because it's believed to play a role in brain cell structure and function.

The capsule also contains several inactive ingredients (calcium phosphate, microcrystalline cellulose, hydroxypropylmethylcellulose, magnesium stearate, silicon dioxide, stearic acid, and water) that help form and preserve the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive function support.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, Age-related cognitive decline, Memory, Learning.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for alpha-GPC is mixed. For Alzheimer disease, it's rated possibly effective — meaning some studies suggest a benefit, but more research is needed to be confident.

For brain tumors, cognitive function, vascular dementia, and stroke, the evidence isn't established enough to rate it one way or another. If you're considering this supplement for a specific cognitive concern, talk with your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, but long-term safety data is limited. Rarely, people have reported dizziness, excitation, headache, insomnia, diarrhea, heartburn, nausea, and vomiting.

More seriously, oral alpha-GPC use for at least 2 months has been rarely associated with stroke compared with people who didn't take it or took it for less than 2 months — a signal that warrants caution with long-term use. The product label notes there isn't enough safety information for pregnancy and lactation, so you should not use it in those situations unless your doctor directs otherwise.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use a scopolamine patch (Transderm Scop) for motion sickness, double-check with your pharmacist before taking this product — alpha-GPC might weaken its effects. No other interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC is a single-ingredient supplement that may help with Alzheimer disease, though the evidence is still developing. If you take a scopolamine patch, check with us before starting this product.

If you're pregnant, breastfeeding, or considering long-term use, talk with your doctor first — the safety data isn't complete.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha GPC 300 mg, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011560029
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 307550
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha GPC 300 mg by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
790011560029
IngredientAmount% DV
Alpha-Glycerylphosphorylcholine300 mg--

Other ingredients: Calcium Phosphate, Hydroxypropylmethylcellulose, Water, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule 1-2 times a day with a meal or as directed by your qualified healthcare professional.

Formula

Alpha GPC (L-alpha glycerylphosphorylcholine) is a phospholipid metabolite found concentrated in neuronal membranes. Alpha GPC is well absorbed and crosses the blood brain barrier. As a substrate involved in the synthesis and secretion of acetylcholine and a precursor to membrane phospholipids, Jarrow Formulas Alpha GPC supports brain function and neuronal health.

Choline source

Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Contains: Soy.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Vegan

Supports brain function Brain health

Non-GMO Gluten free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Copyright 2022 Jarrow Formulas

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha GPC 300 mg by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha GPC 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha GPC 300 mg by Jarrow Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
300 mg per serving Form: L-Alpha-Glycerylphosphorylcholine

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

Other (inactive) ingredients: Calcium Phosphate, Hydroxypropylmethylcellulose, Water, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha GPC 300 mg by Jarrow Formulas Drug Interactions

Want to check YOUR meds against Alpha GPC 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Alpha GPC 300 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha GPC 300 mg interact with drugs. Each result below shows which ingredient is responsible. Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha GPC 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha GPC 300 mg, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas, Inc.
City
Sherman Oaks
State
CA
ZipCode
91403
Phone Number
1-866-459-4154
Web Address
www.Jarrow.com
Pharmacist Counseling Corner

Alpha GPC 300 mg by Jarrow Formulas: Common Questions

Does Alpha GPC 300 mg by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, Alpha GPC 300 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha GPC 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is alpha-GPC and what does it do?
Alpha-GPC is a compound your body makes naturally and that's also in some foods. It plays a role in brain cell structure and function, which is why it's included in supplements aimed at supporting memory and cognitive health.
Does alpha-GPC actually work for memory or cognitive problems?
For Alzheimer disease, it's rated possibly effective — meaning some studies suggest benefit, but we need more evidence. For other cognitive concerns like stroke, vascular dementia, and general cognitive function, the evidence isn't established yet.
What are the side effects?
Alpha-GPC is generally well tolerated, but rarely people report dizziness, headache, insomnia, diarrhea, heartburn, nausea, and vomiting. A more serious concern is that long-term oral use (2 months or more) has been rarely linked to stroke, so this isn't a supplement to take indefinitely without discussing it with your doctor.
Is it safe during pregnancy or while breastfeeding?
There isn't enough safety information to know either way. You should not use this product if you're pregnant or breastfeeding unless your doctor specifically directs you to.
Can I take this with the scopolamine patch for motion sickness?
This is the main interaction to watch. Alpha-GPC might partially decrease the effects of scopolamine, so mention this product to your pharmacist before taking both together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha GPC 300 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha GPC 300 mg label
Go deeper

The Full Monographs Behind Alpha GPC 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha GPC 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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