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Dietary supplement

Alpha GPC 300 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Alpha GPC 300 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha GPC 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha GPC 300 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha GPC 300 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha GPC 300 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha GPC 300 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: alpha-GPC (Alpha glycerophosphocholine), a compound derived from egg yolks and soy that plays a role in brain cell structure and function. Each capsule delivers 300 mg.

The capsule shell and other inactive ingredients—hypromellose, microcrystalline cellulose, magnesium stearate, silicon dioxide, stearic acid, and titanium dioxide—are there to hold the dose together and allow you to swallow it easily.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Cognitive health.
  • We looked for evidence on: Alzheimer disease, Cognitive function, Vascular dementia, Memory, Age-related cognitive decline.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

Alpha-GPC is rated possibly effective for Alzheimer disease based on available evidence. For cognitive function in general, vascular dementia, brain tumors, and stroke, the evidence isn't strong enough to rate whether it works — the studies either don't exist or aren't reliable enough to say.

If you're considering this for memory or thinking problems, talk with your doctor about whether the current evidence supports it for your specific situation.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, but long-term safety hasn't been fully established. A small number of people have reported dizziness, headache, insomnia, nausea, heartburn, or diarrhea.

More concerning: people who took alpha-GPC orally for at least 2 months have been rarely associated with an increased stroke risk compared with non-users or shorter-term users. Stroke is a serious rare side effect on record.

Because there isn't enough safety information overall, the data advises against use unless your doctor has directed you to take it.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use a scopolamine patch (Transderm Scop) for motion sickness — alpha-GPC may reduce how well it works. No other interactions are documented for the ingredient we could check, but because the total interaction data spans 16 individual medications, run your exact prescriptions through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering if your doctor thinks it's appropriate for Alzheimer disease, since it's rated possibly effective for that. However, long-term safety data is limited, and the rare risk of stroke with extended use is something to weigh carefully.

The interaction with scopolamine patches is minor but real. Talk with your own doctor or pharmacist before starting, especially if you take any other medications or have concerns about stroke risk.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha GPC 300 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536035960
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245588
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha GPC 300 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
Servings per container
60
UPC/BARCODE
766536035960
IngredientAmount% DV
Alpha GPC300 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Stearic Acid, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Cognitive health Specialty

Gluten-free Dairy-free Soy-free Nut-free

Does not contain: Gluten, salt, artificial flavors.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Promise Tested & Trusted

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) vegetable capsule up to twice daily, preferably with meals.

Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Formula

Alpha GPC is a phospholipid metabolite derived from lecithin. Alpha GPC supports brain function by promoting the synthesis of acetylcholine, a key brain neurotransmitter.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha GPC 300 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha GPC 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha GPC 300 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Alpha GPC

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha GPC monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Stearic Acid, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha GPC 300 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Alpha GPC 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha GPC 16

Individual Drug Interactions

The ingredients in Alpha GPC 300 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha GPC 300 mg interact with drugs. Each result below shows which ingredient is responsible. Alpha GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha GPC 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha GPC 300 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
The Vitamin Shoppe
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Alpha GPC 300 mg by The Vitamin Shoppe: Common Questions

Does Alpha GPC 300 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Alpha GPC 300 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha GPC 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is alpha-GPC safe to take long-term?
The evidence shows it's generally well tolerated in studies, but long-term safety hasn't been fully established. People who took it for at least 2 months have been rarely associated with an increased stroke risk. Talk with your doctor about whether long-term use is right for you.
Can alpha-GPC really improve memory?
For Alzheimer disease, it's rated possibly effective — there's some evidence it may help. For general cognitive function, vascular dementia, and stroke, the evidence isn't strong enough to know whether it works. Your doctor can advise whether it makes sense for your situation.
What are the common side effects?
A small number of people report dizziness, headache, insomnia, nausea, heartburn, or diarrhea. These are rare, but they do happen. If you experience any of them, let your doctor or pharmacist know.
Should I take this if I'm pregnant or breastfeeding?
There isn't enough safety information on file to know either way. Talk with your doctor or pharmacist for personalized advice on whether it's okay during pregnancy or while breastfeeding.
What's the difference between alpha-GPC and other brain supplements?
We can only tell you about what's in this specific product — one active ingredient, alpha-GPC, at 300 mg per capsule. Other brain supplements have different ingredients and different evidence. Your pharmacist can compare them for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha GPC 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha GPC 300 mg label
Go deeper

The Full Monographs Behind Alpha GPC 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha GPC 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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