Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Alpha-GPC 50% Ingredients & Drug Interactions

by Hard Rhino

Alpha-GPC 50% label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha-GPC 50% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha-GPC 50% is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha-GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Alpha-GPC 50% by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha-GPC 50% by Hard Rhino — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Alpha-GPC 50% by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: alpha-GPC, supplied at 50% concentration as a powder. Alpha-GPC is a natural compound found in the brain that supports the production of acetylcholine, a neurotransmitter involved in memory and attention.

The powder also contains two inactive ingredients — silicon dioxide and ethyl cellulose — which serve as flow agents and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Alpha-gpc's overall clinical evidence instead.

Moderate

Some clinical evidence supports Alpha-gpc for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

Alpha-GPC is rated possibly effective for Alzheimer disease based on available evidence. For cognitive function, brain tumor, vascular dementia, and stroke, the evidence is insufficient to establish whether it works — meaning studies either don't exist, are too small, or are too inconsistent to draw a clear conclusion.

If you're considering alpha-GPC for any condition, talk with your doctor about whether the current evidence supports its use for your specific situation.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in short-term studies, though long-term safety hasn't been fully established. Serious side effects are rare when taken by mouth; the most significant concern documented is a rare risk of stroke, particularly when used for at least 2 months.

Mild side effects reported rarely include dizziness, headache, insomnia, nausea, heartburn, diarrhea, and vomiting. There isn't enough safety information on file to know whether alpha-GPC is safe during pregnancy or while breastfeeding.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take scopolamine (Transderm Scop) for motion sickness, alpha-GPC may reduce how well it works — this is rated Minor, but worth confirming with your doctor or pharmacist. Altogether, these interactions span 16 individual medications.

Run your prescription list through the checker on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC is possibly effective for Alzheimer disease, though evidence for other brain and cognitive conditions remains insufficient. It's generally well tolerated short-term, but long-term safety isn't fully known, and there's a rare stroke risk with extended use.

If you use a scopolamine patch or have a history of stroke, check with your doctor before starting. Have a conversation with your own pharmacist or doctor about whether this product fits your health needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha-GPC 50%, straight from the product label.

Brand Hard Rhino
Barcode (UPC) 818132861815
Net contents 30 Gram(s); 1.05 Oz(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71695
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha-GPC 50% by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.6 Gram(s)
Maximum serving Sizes:
0.6 Gram(s)
Servings per container
50
UPC/BARCODE
818132861815
IngredientAmount% DV
Alpha-GPC300 mg--

Other ingredients: Silicon Dioxide, Ethyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 600mg (~1/8 tsp) with 6-8 ounces of water or suitable beverage. Taken 1-2 times daily, preferably with a meal or as directed by your qualified health professional.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if pressure seal is broken.

FDA Statement of Identity

Dietary Supplement

Formulation

This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.

Storage

Storage: Store in a cool, dry place. Re-seal zipper immediately after use to preserve freshness.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha-GPC 50% by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha-GPC 50% label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha-GPC 50% by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.6 Gram(s) Dosage formPowder Servings per container50 Amounts shown are per serving.

Alpha-GPC

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-GPC monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Ethyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha-GPC 50% by Hard Rhino Drug Interactions

Want to check YOUR meds against Alpha-GPC 50%?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha-GPC 16

Individual Drug Interactions

The ingredients in Alpha-GPC 50% interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha-GPC 50% interact with drugs. Each result below shows which ingredient is responsible. Alpha-GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha-GPC 50% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha-GPC 50%, from the product label.

Hard Rhino

See all Hard Rhino products
Name
Guardian Wholesale
City
Phoenix
State
AZ
ZipCode
85085
Phone Number
(866)961-8378
Web Address
HardRhino.com
Pharmacist Counseling Corner

Alpha-GPC 50% by Hard Rhino: Common Questions

Does Alpha-GPC 50% by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Alpha-GPC 50% has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha-GPC 50% contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does alpha-GPC actually improve memory and thinking?
It's possibly effective for Alzheimer disease based on current evidence. For general cognitive function or thinking speed in healthy people, the evidence is too weak or incomplete to say whether it works. Talk with your doctor if you're considering it for memory concerns.
What side effects have been reported?
Alpha-GPC is generally well tolerated. Rarely, people report mild symptoms like dizziness, headache, insomnia, nausea, heartburn, or diarrhea. Very rarely, stroke has been documented, especially when used for 2 months or longer. Most users don't experience problems, but it's worth knowing the rare possibilities.
Is it safe to take while breastfeeding?
There isn't enough safety data on file to say whether alpha-GPC is safe during breastfeeding. Talk with your doctor or pharmacist before using it if you're nursing — they can help you weigh the risks and benefits for your situation.
What's alpha-GPC actually for?
Alpha-GPC is a compound your brain naturally produces. It helps make acetylcholine, a brain chemical involved in memory and focus. It's studied mainly for age-related memory loss and dementia.
Is this just a filler powder with no active ingredient?
No — alpha-GPC is the active ingredient here. The powder also contains silicon dioxide and ethyl cellulose, which are inactive fillers that help the powder flow and hold together, but they're not the therapeutic part.
What happens if I take this with my scopolamine patch?
Alpha-GPC may weaken how well the scopolamine patch works for motion sickness by partially counteracting its effects. This interaction is minor, but check with your doctor or pharmacist before combining them to make sure it won't interfere with what you need the patch for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha-GPC 50% is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha-GPC 50% label
Go deeper

The Full Monographs Behind Alpha-GPC 50%’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha-GPC 50%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team