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Dietary supplement

Alpha GPC 50% Powder Ingredients & Drug Interactions

by Nootropics Depot

Alpha GPC 50% Powder label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha GPC 50% Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha GPC 50% Powder is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha GPC 50% Powder by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha GPC 50% Powder by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha GPC 50% Powder by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: alpha-GPC, a compound your brain naturally makes. Alpha-GPC is a source of choline, which your body uses to make acetylcholine — a chemical messenger involved in memory and learning.

The powder form lets you mix it into food or drink.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Alpha-gpc's overall clinical evidence instead.

Moderate

Some clinical evidence supports Alpha-gpc for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

The evidence for alpha-GPC is mixed. It's rated possibly effective for Alzheimer disease — meaning some research supports it, but more work is needed to be sure.

For brain tumor, cognitive function, vascular dementia, and stroke, the evidence isn't established enough in our data to make a rating. If you're considering it for any of these uses, talk with your doctor about what the current research actually shows for your situation.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated when taken by mouth, but long-term safety hasn't been fully studied. Rarely, people have reported dizziness, headache, insomnia, nausea, heartburn, and diarrhea.

More concerning: oral use for at least 2 months has been rarely associated with an elevated stroke risk compared with non-users or shorter-term users — a serious adverse effect. There isn't enough safety information on file to know whether it's safe in pregnancy or while breastfeeding.

Talk with your doctor or pharmacist before starting if you're pregnant, nursing, or have had a stroke.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use scopolamine (Transderm Scop) patches, check with your doctor or pharmacist before taking this product — alpha-GPC may decrease its effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering if you're looking into options for Alzheimer disease, though the evidence is still developing. If you take scopolamine patches for motion sickness, check with your doctor or pharmacist first — alpha-GPC might reduce how well the patch works.

Because long-term safety isn't fully established and stroke risk has been reported with months of use, it's smart to discuss this with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha GPC 50% Powder, straight from the product label.

Brand Nootropics Depot
Net contents 10 Gram(s); 0.35 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231955
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha GPC 50% Powder by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.6 Gram(s)
Maximum serving Sizes:
0.6 Gram(s)
Servings per container
16
IngredientAmount% DV
Alpha GPC300 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

Sample Disclaimer: Transfer scoops are not accurate. A mg scale is needed to measure dosages.

Precautions

Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take if under 18, pregnant/nursing, having any medical/nursing, have any medical conditions or taking FDC/OTC drugs.

Do not take if under 18, pregnant/nursing, having any medical/nursing, have any medical conditions or taking FDC/OTC drugs.

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the FDA.

Suggested/Recommended/Usage/Directions

Suggested use: As dietary supplement, take 600mg once daily.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha GPC 50% Powder by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha GPC 50% Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha GPC 50% Powder by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.6 Gram(s) Dosage formPowder Servings per container16 Amounts shown are per serving.

Alpha GPC

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha GPC monograph & interactions
Interaction report

Alpha GPC 50% Powder by Nootropics Depot Drug Interactions

Want to check YOUR meds against Alpha GPC 50% Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha GPC 16

Individual Drug Interactions

The ingredients in Alpha GPC 50% Powder interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha GPC 50% Powder interact with drugs. Each result below shows which ingredient is responsible. Alpha GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha GPC 50% Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha GPC 50% Powder, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Pharmacist Counseling Corner

Alpha GPC 50% Powder by Nootropics Depot: Common Questions

Does Alpha GPC 50% Powder by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Alpha GPC 50% Powder has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha GPC 50% Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is alpha-GPC proven to work for memory or Alzheimer disease?
For Alzheimer disease, the evidence is promising enough to rate it possibly effective — meaning some research supports it, but more studies are needed. For general cognitive function, brain tumor, vascular dementia, and stroke, we don't have enough reliable evidence to say how well it works.
What side effects might I notice?
Most people tolerate it well. Rarely, people report dizziness, headache, insomnia, nausea, heartburn, or diarrhea. One concerning finding: use for at least 2 months has been rarely linked to an elevated stroke risk compared with non-users or those who used it short-term. That's serious enough to discuss with your doctor.
Is it safe if I'm pregnant or breastfeeding?
There isn't enough information on file to know either way. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing — they can help you weigh what's known and what's best for you.
I use a scopolamine patch for motion sickness. Can I take this?
A small study suggests alpha-GPC may reduce scopolamine's effects on memory and attention. Whether it weakens the patch's anti-nausea benefit isn't clear yet. Check with your doctor or pharmacist before combining them.
How much long-term safety data is there?
Long-term safety hasn't been fully established. Most studies are shorter-term, so we don't have a complete picture of what happens if you take it for years.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha GPC 50% Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha GPC 50% Powder label
Go deeper

The Full Monographs Behind Alpha GPC 50% Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha GPC 50% Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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