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Dietary supplement

Alpha-GPC 99% Powder Ingredients & Drug Interactions

by Nootropics Depot

Alpha-GPC 99% Powder label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha-GPC 99% Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha-GPC 99% Powder is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha-GPC 99% Powder by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha-GPC 99% Powder by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha-GPC 99% Powder by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a single-ingredient product: alpha-GPC, a compound naturally found in the brain that plays a role in memory and thinking. The powder is 99% pure, with no other active ingredients or added fillers listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Alpha-gpc's overall clinical evidence instead.

Moderate

Some clinical evidence supports Alpha-gpc for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

For Alzheimer disease, alpha-GPC is rated possibly effective — the evidence shows promise but isn't conclusive. For cognitive function in otherwise healthy people, brain tumor, vascular dementia, and stroke, the evidence we hold is insufficient to rate it one way or the other.

You'd be using this mostly on the strength of preliminary research rather than solid proof it works for those aims.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, alpha-GPC is generally well tolerated in study settings, though long-term safety hasn't been fully established. Serious side effects are rare but include stroke — notably, regular use for at least 2 months has been associated with a higher stroke risk compared with non-users.

More common minor effects, reported rarely, include dizziness, headache, insomnia, nausea, heartburn, diarrhea, and vomiting. The safety information available doesn't give us enough detail about use in pregnancy or breastfeeding.

Talk with your doctor or pharmacist before using this product if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use scopolamine (Transderm Scop) for motion sickness. Alpha-GPC may reduce how well it works.

This is a Minor interaction, but worth confirming your situation before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC might be worth considering if you're interested in memory support, especially for Alzheimer disease, but the evidence for other uses is still being worked out. The biggest caution is the rare but documented link to stroke with longer-term use — that's worth discussing with your doctor before you start.

Check your current medications against the interaction tool below, especially if you use a motion sickness patch.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha-GPC 99% Powder, straight from the product label.

Brand Nootropics Depot
Net contents 2.11 Ounce(s); 60 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231963
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha-GPC 99% Powder by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.3 Gram(s)
Maximum serving Sizes:
0.3 Gram(s)
Servings per container
200
IngredientAmount% DV
Alpha GPC300 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Warnings: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 300mg once daily.

General Statements

Transfer scoops are not accurate forms of measurement. A milligram scale is needed to accurately measure dosages.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha-GPC 99% Powder by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha-GPC 99% Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha-GPC 99% Powder by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.3 Gram(s) Dosage formPowder Servings per container200 Amounts shown are per serving.

Alpha GPC

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha GPC monograph & interactions
Interaction report

Alpha-GPC 99% Powder by Nootropics Depot Drug Interactions

Want to check YOUR meds against Alpha-GPC 99% Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha GPC 16

Individual Drug Interactions

The ingredients in Alpha-GPC 99% Powder interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha-GPC 99% Powder interact with drugs. Each result below shows which ingredient is responsible. Alpha GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha-GPC 99% Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha-GPC 99% Powder, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Alpha-GPC 99% Powder by Nootropics Depot: Common Questions

Does Alpha-GPC 99% Powder by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Alpha-GPC 99% Powder has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha-GPC 99% Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does alpha-GPC actually do?
Alpha-GPC is a brain compound involved in memory and mental function. The research suggests it may help with Alzheimer disease, but for healthy people wanting to sharpen their thinking, the evidence isn't solid yet.
What are the side effects I should watch for?
Most people tolerate it well, but rarely it can cause dizziness, headache, insomnia, nausea, heartburn, or vomiting. More seriously, long-term use (2 months or more) has been linked to an elevated stroke risk — that's the one to discuss with your doctor before starting.
Is it safe to take if I'm pregnant or breastfeeding?
We don't have enough safety information to say either way. Talk with your doctor or pharmacist before using it if you're pregnant, planning pregnancy, or nursing — they can give you personalized advice based on your situation.
How long does it take to work?
The facts we hold don't say how quickly you might notice a difference. That's a good question for your doctor or pharmacist based on how it's been studied.
Does it interact with anything besides the motion sickness patch?
The only documented interaction we have is with scopolamine (Transderm Scop). That said, always run your complete medication list through the checker on this page to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha-GPC 99% Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha-GPC 99% Powder label
Go deeper

The Full Monographs Behind Alpha-GPC 99% Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha-GPC 99% Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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