Andrographis Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Andrographis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Andrographis is a dietary supplement by Doctor's Best with 3 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 638 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis Leaf Extract, Vitamin C, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Andrographis by Doctor's Best
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HelloPharmacist Scorecard of Andrographis by Doctor's Best
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 3 active ingredients. Zinc is a mineral that plays a role in immune function, wound healing, and protein synthesis.
Vitamin C is an antioxidant vitamin involved in immune support and collagen formation. Andrographis leaf extract and andrographolide are botanical ingredients — andrographolide is the plant's active compound.
The tablet also contains several inactive ingredients including microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, silicon dioxide, and hypromellose, which are typical binders and fillers.
Does it work?
Moderate evidence
Zinc is effective for zinc deficiency and likely effective for Wilson disease (a copper-storage disorder). It's possibly effective for acne, age-related macular degeneration, diabetes, and acrodermatitis enteropathica.
Vitamin C is effective for vitamin C deficiency and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections. Evidence for the other ingredients in this product is not established in the data we hold.
How safe is it?
Well-documented data
Zinc is generally well tolerated at recommended doses below 40 mg daily, but high doses can cause abdominal cramps, diarrhea, metallic taste, nausea, and vomiting. Long-term high-dose zinc (above the tolerable upper intake level) carries a theoretical risk of copper deficiency, which could lead to anemia.
Vitamin C is well tolerated at normal and supplement doses but very high doses — above 2 grams daily — can cause abdominal cramping, heartburn, diarrhea, nausea, and kidney stones in people prone to them. During pregnancy, vitamin C at normal dietary amounts is likely safe, but the data shows conflicting safety signals at high doses; normal amounts during lactation are considered safe.
Zinc in pregnancy is listed with conflicting safety signals (likely safe in one entry, likely unsafe in another), so talk with your doctor about prenatal zinc use.
Meds to double-check
Moderate interaction found
Check your medications against this product if you take quinolone antibiotics (like ciprofloxacin), tetracycline antibiotics (like doxycycline), cephalexin, penicillamine, ritonavir or other HIV drugs, any blood thinner like warfarin, levothyroxine (thyroid medication), estrogens (oral contraceptives or hormone replacement therapy), or chemotherapy. The zinc and vitamin C in this supplement can reduce how well these drugs work or change how much of them your body absorbs.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're looking to support immune function or address a zinc or vitamin C gap — but only if you're not taking antibiotics, blood thinners, thyroid medication, HIV drugs, or cancer treatments. If you take any prescription medication, run it through the checker on this page before starting.
A conversation with your pharmacist is especially important if you're pregnant, breastfeeding, or on a long-term medication.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Andrographis, straight from the product label.
| Brand | Doctor's Best |
|---|---|
| Barcode (UPC) | 753950005679 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Feb 22, 2024 |
| DSLD ID | 302637 |
| Product type | Botanical With Nutrients |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Andrographis by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Zinc | 5.5 mg | 50% |
| Vitamin C | 180 mg | 200% |
| Andrographolide | 60 mg | -- |
| Andrographis Leaf Extract | 200 mg | -- |
Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hypromellose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Andrographis is made with AP-Bio andrographis extract, which is specially formulated to 30% andrographolide content (60 mg per serving), making it the most potent andrographis extract available. Typically, other andrographis extracts are standardized to 10% or less. Andrographolides are the primary bioactive constituents responsible for the immunomodulatory effects of the andrographis leaf. The andrographolide immune boost present in a multitude of ways including increased natural killer cell and phagocyte activity. Andrographolides can also aid healthy immune response by antioxidant action and modulating cytokine activity which may support respiratory health. Andrographis also contains vitamin C and zinc which may achieve respiratory comfort in a complementary manner, thus providing powerful immune support in the form of a tablet.
AP-Bio
Formulation
Immune system support Promotes respiratory health
3x Immune System Support
Vegan
Gluten free / Soy Free / Vegan
Gluten free / Soy Free / Vegan
This product contains natural ingredients that may vary in color.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
Science-Based Nutrition AP-Bio
AP-Bio is a registered trademark of Natural Remedies Private LTD., exclusively distributed by AIDP in North America.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested adult use: Take 2 tablets daily, or as recommended by a nutritionally informed physician.
Precautions
Warning: Avoid use of Andrographis if you are pregnant, nursing or have an autoimmune condition.
Consult a physician before use if you have an existing medical condition.
Storage
Store in a cool dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Andrographis by Doctor's Best label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Andrographis by Doctor's Best
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Zinc
Interacts with67 drugs
Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...
Zinc monograph & interactionsVitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsAndrographis Leaf Extract
Interacts with413 drugs
Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...
Andrographis Leaf Extract monograph & interactions- › Andrographolide
Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hypromellose. These complete the product’s ingredient list but are not active constituents.
Andrographis by Doctor's Best Drug Interactions
HelloPharmacist Interaction Report
Andrographis by Doctor's Best contains zinc and vitamin C, both of which interact with a number of medications.
Zinc's most serious interactions are Moderate in severity and affect several antibiotic classes. Zinc reduces absorption of quinolone antibiotics, tetracycline antibiotics, and cephalexin — all of which work by being absorbed into your bloodstream — and it can also interfere with penicillamine, ritonavir (an HIV medication), and theoretically with the cancer drug cisplatin and HIV integrase inhibitors.
The remedy for most zinc–antibiotic interactions is timing: take the antibiotic at least 2 hours before or 4–6 hours after your zinc supplement.
Read the full breakdown — every affected drug type, severity by severity
Vitamin C carries Moderate interactions with estrogens (oral contraceptives and hormone replacement therapy), certain chemotherapy drugs, warfarin (a blood thinner), levothyroxine (thyroid medication), and a few others. High-dose vitamin C can reduce warfarin's blood-thinning effect or interfere with how your body absorbs the thyroid drug — both situations where dose timing or monitoring may matter.
Vitamin C can also increase aluminum absorption and theoretically reduce the effectiveness of some cancer treatments.
We could not check the ingredient andrographolide for interactions, as we hold no data for it. Altogether, these interactions span 270 individual medications.
Use the search tool below to check your exact medications against this product before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Andrographis?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Andrographis interact with 638 drugs. Click any drug to see the details.
3 of the 3 ingredients in Andrographis interact with drugs. Each result below shows which ingredient is responsible. Andrographis Leaf Extract Vitamin C Zinc
Aluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amiloride interactionZincAmiloride (midamor) Minor
Interaction Summary
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Read the full Zinc + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amiloride, Hydrochlorothiazide interactionZincAmiloride (midamor) Minor
Interaction Summary
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Read the full Zinc + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs, Celecoxib (celebrex) Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Ammonium Chloride interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
ZincTetracycline Antibiotics Moderate
Interaction Summary
Zinc might reduce levels of tetracycline antibiotics.
Read the full Zinc + Amphotericin, Tetracycline interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Leaf Extract + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Antithrombin Iii interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Leaf Extract + Antithymocyte Globulin interactionApixabanEliquis
How Apixaban interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Apixaban interactionAprocitentanTryvio
How Aprocitentan interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Leaf Extract + Aprocitentan interactionArgatrobanArgatroban
How Argatroban interacts with Andrographis — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin interactionVitamin CAspirin Minor
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAndrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin, Butalbital interactionVitamin CAspirin Minor
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin, Butalbital, Caffeine interactionVitamin CAspirin Minor
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionVitamin CAspirin Minor
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionVitamin CAspirin Minor
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Andrographis — through 2 ingredients. Tap an ingredient for the detail:
Andrographis Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Leaf Extract + Aspirin, Caffeine interactionVitamin CAspirin Minor
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Andrographis with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Andrographis Leaf Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.
Antihypertensive Drugs
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.
Immunosuppressants
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.
Celecoxib (Celebrex)
Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.
Etoricoxib (Arcoxia)
Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.
Glipizide (Glucotrol)
Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Zinc
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.
Cephalexin (Keflex)
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.
Cisplatin (Platinol-Aq)
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.
Integrase Inhibitors
Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.
Penicillamine (Cuprimine, Depen)
Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.
Quinolone Antibiotics
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.
Ritonavir (Norvir)
Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.
Tetracycline Antibiotics
Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.
Amiloride (Midamor)
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.
Atazanavir (Reyataz)
Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.
Brand information
Manufacturer and brand details for Andrographis, from the product label.
Doctor's Best
See all Doctor's Best products- Name
- Doctor's Best, Inc.
- City
- Tustin
- State
- California
- ZipCode
- 92780
- Phone Number
- (800) 777-2474
- Web Address
- www.drbvitamins.com
Andrographis by Doctor's Best: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Andrographis’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Zinc
Interacts with 67 drugsZinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...
Read the full Zinc monograph → Herb & supplement monographVitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph → Herb & supplement monographAndrographis
Interacts with 413 drugsAndrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...
Read the full Andrographis monograph →Sources & How We Checked
Andrographis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 165 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Zinc 88 references
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Vitamin C 51 references
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