Drug & supplement interaction

Andrographis + Amlodipine, Celecoxib

Amlodipine, Celecoxib brand name: Consensi.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Amlodipine, Celecoxib falls into 2 drug categories that Andrographis can interact with; the most serious is rated moderate. Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Andrographis and Amlodipine, Celecoxib

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Andrographis interacts with whole categories of medication. Amlodipine, Celecoxib falls into 2 of those categories, so it can interact with Andrographis in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Amlodipine, Celecoxib

Amlodipine, Celecoxib falls under ANTIHYPERTENSIVE DRUGS — the group Andrographis interacts with.

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Consensi combines two medicines: amlodipine (a blood pressure pill) and celecoxib (an anti-inflammatory for pain). The interaction we're flagging here is really about the amlodipine part. In animal studies, andrographis seemed to lower blood pressure on its own. So the worry is that pairing it with a blood pressure medicine like amlodipine could add up and push your readings too low.

If that happened, you might feel dizzy, lightheaded, tired, or notice your heart racing, especially when standing up quickly. I want to be honest though: this is only a theoretical concern based on lab and animal work, not solid human studies, so it may not amount to much in real life. Still, if you take Consensi and want to try andrographis, please check with your pharmacist or doctor first, and keep an eye on your blood pressure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  2. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
Minor

CELECOXIB (Celebrex)

2 of 2
Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Consensi is a combination pill that pairs amlodipine (for blood pressure) with celecoxib (an anti-inflammatory pain reliever). The interaction on file deals with the celecoxib part. In animal studies, andrographis nudged up the peak blood level of celecoxib and shifted when that peak hit, but the total amount absorbed over time looked unchanged.

What does that mean for you in real life? Honestly, probably very little. This is a minor, theoretical finding based only on lab and animal work, not on people. Even if a slightly higher peak occurred, the most you might notice is a touch more of celecoxib's usual effects, like stomach upset. Neither drug is a prodrug here, so nothing flips. Still, if you take both regularly, just give your pharmacist a heads-up so they can keep an eye on things.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Andrographis Also Interacts With Other Medications

Andrographis has 407 moderate, 5 minor known drug interactions in our database — the Amlodipine, Celecoxib one above is among them. If you take anything else, check it against the full list below.

Moderate 407 Minor 5 No known interaction 2,418 (incl. Amlodipine, Celecoxib)
Taking anything else?

Check Another of Your Medications Against Andrographis

Covers the 2,830 medications we’ve checked against Andrographis. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Amlodipine, Celecoxib

This page covers Andrographis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amlodipine, Celecoxib page lists 266 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Beer (major).

By severity: 11 major · 211 moderate · 44 minor.

From our pharmacist’s overview on the Amlodipine, Celecoxib page

“Grapefruit is the risk I would want a Consensi patient to grasp first. Consensi pairs amlodipine and celecoxib to treat high blood pressure and arthritis pain, and grapefruit blocks the enzyme that clears amlodipine, raising its levels.”

Reviewed by 2 · Jul 18, 2026

Open the Amlodipine, Celecoxib interaction page

One more smart check

Taking Andrographis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 656 real supplement products containing Andrographis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Andrographis. Your product may carry other ingredients that interact with Amlodipine, Celecoxib too, on top of Andrographis — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Andrographis and Amlodipine, Celecoxib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andrographis
Top 25%

#159 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amlodipine, Celecoxib
Steady interest

#1,431 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Andrographis

What is Andrographis?

Andrographis
  • Common cold and flu symptoms
  • Upper respiratory infections
  • Sore throat
  • Fever
  • Immune support
  • Digestive complaints

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limited and the quality of studies varies, so it should not replace standard care. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy.

Read the full Andrographis monograph & all interactions
Keep checking

Other Drugs & Andrographis

Browse every other medication we’ve checked against Andrographis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
407Moderate
5Minor
2,417No known interaction
407 Moderate 5 Minor 2,417 No interaction
Moderate

407 interactions

Showing 60 of 407 moderate interactions — see all 407 on the Andrographis page.

Minor

5 interactions

No interaction 2,417 drugs checked — show the list

We also checked Andrographis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,417 medications checked with no known interaction — see the full Andrographis list.

See the full Andrographis interactions page
See every supplement checked against Amlodipine, Celecoxib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Andrographis monograph › Uses, safety, and every drug interaction in one place Amlodipine, Celecoxib supplement interactions › Every supplement checked against Amlodipine, Celecoxib, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Andrographis and Amlodipine, Celecoxib Together: Common Questions

Can you take Andrographis with Amlodipine, Celecoxib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Andrographis and Amlodipine, Celecoxib?
Amlodipine, Celecoxib belongs to more than one drug category, and Andrographis interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Andrographis and Amlodipine, Celecoxib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.