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Dietary supplement

Annatto Tocotrienols Ingredients & Drug Interactions

by Designs for Health

Annatto Tocotrienols label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Annatto Tocotrienols against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Annatto Tocotrienols is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Annatto Tocotrienols by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Annatto Tocotrienols by Designs for Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Annatto Tocotrienols by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tocotrienols, a form of vitamin E derived from annatto. The capsule also contains inactive ingredients — silicon dioxide, microcrystalline cellulose, and magnesium stearate — which are common binders and flow agents used to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tocotrienols's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tocotrienols for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

The evidence for tocotrienols is mixed. For diabetes, the data suggests it's possibly effective — meaning there's some promise but it's not yet proven.

For high cholesterol, the evidence points the other way: it's rated possibly ineffective. For alopecia areata (patchy hair loss) and breast cancer, there isn't enough reliable evidence in our data to rate it either way.

The evidence, ingredient by ingredient Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, tocotrienols appear to be well tolerated — no adverse effects were reported in clinical trials we have on file. Long-term safety at supplement doses, though, hasn't been well studied.

During pregnancy, there isn't enough safety information, so the data advises against supplemental doses. While breastfeeding, safety information is limited; talk with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Tocotrienols

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on blood thinners (anticoagulants) or antiplatelet drugs like warfarin, aspirin, or clopidogrel, check your medications against the interaction tool below before you start. The risk is rated Minor and hasn't been confirmed in people, but it's worth confirming your specific drugs are compatible.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Tocotrienols might be worth considering if you're interested in managing blood sugar, though the evidence is preliminary. If you take blood thinners or antiplatelet drugs, check with your doctor or pharmacist before starting — the theoretical bleeding risk needs to be weighed for your situation.

Pregnant or breastfeeding? Discuss this with your healthcare provider first.

For anyone else, this supplement appears well tolerated overall.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Annatto Tocotrienols, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452001534
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22260
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Annatto Tocotrienols by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
879452001534
IngredientAmount% DV
Tocotrienols100 mg--

Other ingredients: Silicon Dioxide, Microcrystalline Cellulose, Magnesium Stearates

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

Formulation

Does not contain gluten.

General

ANT060

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Manufactured in a GMP CERTIFIED Facility

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule daily in the evening with food, or as directed by your health care practitioner. For best results, do not take within six hours of taking a vitamin E supplement containing d-alpha tocopherol.

Brand IP Statement(s)

DeltaGold(R) is naturally extracted from annatto bean, under US patent (6,350,453) to American River Nutrition, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Annatto Tocotrienols by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Annatto Tocotrienols label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Annatto Tocotrienols by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Tocotrienols

Interacts with
122 drugs
100 mg per serving Form: D-Gamma-Tocotrienol, delta {tocotrienol}

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Tocotrienols monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Microcrystalline Cellulose, Magnesium Stearates. These complete the product’s ingredient list but are not active constituents.

Interaction report

Annatto Tocotrienols by Designs for Health Drug Interactions

Want to check YOUR meds against Annatto Tocotrienols?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

Tocotrienols 122

Individual Drug Interactions

The ingredients in Annatto Tocotrienols interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Annatto Tocotrienols interact with drugs. Each result below shows which ingredient is responsible. Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in Annatto Tocotrienols with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Annatto Tocotrienols, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

Annatto Tocotrienols by Designs for Health: Common Questions

Does Annatto Tocotrienols by Designs for Health interact with any medications?
Yes. Based on its ingredients, Annatto Tocotrienols has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Annatto Tocotrienols contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this supplement actually help with high cholesterol?
The evidence suggests it's possibly ineffective for high cholesterol. If lowering cholesterol is your goal, talk with your doctor about what's been proven to work for you.
What are tocotrienols anyway?
Tocotrienols are a form of vitamin E. In this product, they come from annatto, a natural seed.
Are there any side effects if I take it by mouth?
No adverse effects were reported in the clinical trials we have on file. It appears to be well tolerated when taken orally.
Is it safe to take while I'm pregnant?
There isn't enough safety information to know either way during pregnancy. The data advises against supplemental doses, so talk with your doctor or pharmacist for personalized advice.
Can I take this if I'm breastfeeding?
Safety information while breastfeeding is limited. Your doctor or pharmacist can help you decide whether it's right for you while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Annatto Tocotrienols is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Annatto Tocotrienols label
Go deeper

The Full Monographs Behind Annatto Tocotrienols’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Annatto Tocotrienols's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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