Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Annatto Vitamin E 125 mg Ingredients & Drug Interactions

by Chief Originals

Annatto Vitamin E 125 mg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Annatto Vitamin E 125 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Annatto Vitamin E 125 mg is a dietary supplement by Chief Originals with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Annatto Vitamin E 125 mg by Chief Originals

Ask about any prescription or over-the-counter medication and we check it for interactions with Annatto Vitamin E 125 mg by Chief Originals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Annatto Vitamin E 125 mg by Chief Originals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tocotrienols, a form of vitamin E. Tocotrienols are naturally occurring compounds that function as antioxidants in your body.

The product also includes vitamin E and softgel capsule materials as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tocotrienols's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tocotrienols for:

Why this rating?
  • The label markets general wellness (“antioxidant support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

The evidence for tocotrienols is mixed. It's rated possibly effective for blood sugar control in diabetes, but possibly ineffective for lowering cholesterol.

For alopecia areata (patchy hair loss) and breast cancer, there isn't enough reliable evidence yet to know whether it works.

The evidence, ingredient by ingredient Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tocotrienols are generally well tolerated in studies, though long-term safety at supplement doses hasn't been firmly established. There isn't enough safety data to know whether it's safe during pregnancy — the data advises against supplemental doses during that time.

For breastfeeding, there's little safety information available; talk with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Tocotrienols

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before adding this to your routine if you take blood thinners or antiplatelet drugs — tocotrienols may raise the risk of bleeding, though this hasn't been confirmed in actual patients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

Annatto Vitamin E may be worth considering if you're interested in blood sugar support and are looking for a tocotrienol source. If you take any blood thinners or antiplatelet medications, check with your doctor or pharmacist before you start, since the interaction hasn't been observed in people but remains theoretically possible.

Pregnant or breastfeeding? Clear it with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Annatto Vitamin E 125 mg, straight from the product label.

Brand Chief Originals
Barcode (UPC) 050742584825
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 250744
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Annatto Vitamin E 125 mg by Chief Originals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
050742584825
IngredientAmount% DV
Tocotrienols125 mg--

Other ingredients: Vitamin E, Softgel Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Annatto Vitamin E Delta/Gamma Tocotrienols With up to 60x greater antioxidant potential than tocopherols, tocotrienols are the most potent form of vitamin E found in nature. Chief Originals Annatto Vitamin E Delta/Gamma Tocotrienols is derived from the annatto plant, the best naturally occurring source of vitamin E with an ideal composition of delta- and gamma-tocotrienols. This superior form of vitamin E can support your overall cardiovascular and metabolic health. It contains no GMOs or gluten and is highly bioavailable, non-toxic and non-China. It is also tested for glyphosate, heavy metals and microbiology.

Glyphosate tested Laboratory verified

Non GMO Non Toxic

China free

Precautions

Manufactured in a facility which may contain nuts (peanuts, tree nuts).

If pregnant or under a doctor's care, consult your physician before using this product.

Do not use if the safety seal is broken.

Keep out of reach of children.

General Statements

A percent of all profits to Native American causes

Formula

Delta/Gamma Tocotrienols

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place away from direct sunlight. Fully close the bottle after each use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Annatto Vitamin E 125 mg by Chief Originals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Annatto Vitamin E 125 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Annatto Vitamin E 125 mg by Chief Originals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Tocotrienols

Interacts with
122 drugs
125 mg per serving Form: DeltaGOLD Tocotrienols

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Tocotrienols monograph & interactions

Other (inactive) ingredients: Vitamin E, Softgel Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Annatto Vitamin E 125 mg by Chief Originals Drug Interactions

Want to check YOUR meds against Annatto Vitamin E 125 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

Tocotrienols 122

Individual Drug Interactions

The ingredients in Annatto Vitamin E 125 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Annatto Vitamin E 125 mg interact with drugs. Each result below shows which ingredient is responsible. Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in Annatto Vitamin E 125 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Annatto Vitamin E 125 mg, from the product label.

Chief Originals

See all Chief Originals products
Name
Chief Originals LLC
Street Address
3820 Central Ave. Unit #109
City
Cheyenne
State
WY
ZipCode
82001
Phone Number
1-888-959-6415
Web Address
chieforiginals.com
Pharmacist Counseling Corner

Annatto Vitamin E 125 mg by Chief Originals: Common Questions

Does Annatto Vitamin E 125 mg by Chief Originals interact with any medications?
Yes. Based on its ingredients, Annatto Vitamin E 125 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Annatto Vitamin E 125 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The safety data advises against it. There isn't enough information to know whether it's safe at supplement doses during pregnancy, so talk with your doctor or pharmacist about whether it's right for you.
Is it safe to breastfeed while taking this?
There's very little safety information available for breastfeeding. If you're nursing, check with your doctor or pharmacist before starting it.
Does tocotrienol help with high cholesterol?
The evidence suggests it's probably not effective for lowering cholesterol, according to the research we have on file.
What side effects has tocotrienol caused in studies?
When taken by mouth, tocotrienols appear well tolerated, and no adverse effects have been reported in clinical trials.
How many active ingredients are in this product?
One — tocotrienols, a form of vitamin E.
Will it help with my blood sugar?
Tocotrienols are rated possibly effective for diabetes, so there's some evidence they may help, but it's not strong enough to be certain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Annatto Vitamin E 125 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Annatto Vitamin E 125 mg label
Go deeper

The Full Monographs Behind Annatto Vitamin E 125 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Annatto Vitamin E 125 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team