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Dietary supplement

Antiflame Ingredients & Drug Interactions

by Simply Best

Antiflame label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Antiflame against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Antiflame is a dietary supplement by Simply Best with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mangoselect. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Antiflame by Simply Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Antiflame by Simply Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Antiflame by Simply Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Antiflame contains one active ingredient: mangosteen (labeled as Mangoselect). The rest is an HPMC vegetarian capsule, which is the inactive capsule material that holds the ingredient.

Mangosteen is a tropical fruit traditionally used for inflammatory conditions. This product concentrates that plant material into a supplement form.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Mangosteen's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: body's healing processes and general wellness.
  • We looked for evidence on: Osteoarthritis, Atopic dermatitis (eczema), Muscle fatigue, Muscle strength, inflammatory conditions, wound healing — and 1 related terms.
  • The closest evidence on file: Mangosteen is rated "Insufficient Reliable Evidence To Rate" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Mangosteen is rated "Insufficient Reliable Evidence To Rate" for Muscle fatigue, Muscle strength, Osteoarthritis.

The evidence for mangosteen is mixed. It's rated possibly effective for periodontitis (gum disease), based on available studies.

For androgenic alopecia (male pattern baldness), atopic dermatitis (eczema), and Alzheimer's disease, the evidence isn't established enough to rate — we simply don't have reliable data yet on whether it works for those uses.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen is generally well tolerated as a food, though long-term safety of concentrated supplements hasn't been thoroughly studied. In trials using mangosteen extract up to 560 mg daily, a small number of participants reported mild tiredness, headache, dizziness, and malaise — though it's not clear whether mangosteen caused these.

Gastrointestinal symptoms like constipation, nausea, diarrhea, and abdominal bloating were also reported in some cases, along with dry throat, cough, and flu-like symptoms. During pregnancy and breastfeeding, there isn't enough safety information.

The safety data advises against supplement amounts of mangosteen in both situations — talk with your doctor or pharmacist about your specific circumstances.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Antiflame, double-check any blood thinners or antiplatelet medications you're on (like warfarin, aspirin, or clopidogrel)—mangosteen may increase bleeding risk. Also mention it if you take donepezil (Aricept).

Use the search tool on this page to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Antiflame may be worth considering if you're interested in gum health support, since mangosteen shows some evidence for periodontitis. However, if you take blood thinners or antiplatelet drugs—or donepezil for Alzheimer's—check with us first.

Pregnant or breastfeeding? Skip this until you've talked it over with your doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Antiflame, straight from the product label.

Brand Simply Best
Barcode (UPC) 5060370563708
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 24, 2017
DSLD ID 70795
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Antiflame by Simply Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
5060370563708
IngredientAmount% DV
Mangoselect300 mg--

Other ingredients: HPMC Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Simply Supplements

Mangoselect

Formula

Product Information Containing a derivative of mangosteen, forming part of Mangoselect, which is recognised as having phenomenal levels of xanthones which are thought to support and enhance the body’s healing processes.

Suggested/Recommended/Usage/Directions

Suggested Daily Intake Take two to three capsules daily as a food supplement or as directed by a healthcare professional.

Precautions

Important Information If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of our products, always consult your GP or Pharmacist prior to taking supplements.

Do not exceed stated dose.

Keep away from children at all times.

Do not use if seal is broken.

Pregnant or lactating women should consult a doctor before using this product.

Food Supplement: This product should not be used as a substitute for a varied diet.

General Statements

AutoDespatch Save 10% and get free P&P on all repeat orders by having your favourite supplements conveniently scheduled and delivered automatically with our unique AutoDespatch system. Same day despatch We will ensure your order is despatched on the day of receipt (when placed before 12.30pm) and that all orders placed after 12.30pm are despatched on the next working day. All sent 1st class!

PriceMatch guarantee! If you buy from us and then see the same product cheaper elsewhere we will refund the difference plus 10%!

Image is for illustration purposes only.

EasyGest capsules ~ Easy to swallow ~ Easy to absorb ~ Easy to digest ~ No product odour ~ No bad taste

Supporting the healing process

Unprecedented quality and purity

Formulation

V Vegetarian

Suitable for vegetarians.

General

E705

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Antiflame by Simply Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Antiflame label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Antiflame by Simply Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Mangoselect

Interacts with
125 drugs
300 mg per serving

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supp...

Mangoselect monograph & interactions

Other (inactive) ingredients: HPMC Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Antiflame by Simply Best Drug Interactions

Want to check YOUR meds against Antiflame?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Mangoselect 125

Individual Drug Interactions

The ingredients in Antiflame interact with 125 drugs. Click any drug to see the details.

1 of the 1 ingredient in Antiflame interact with drugs. Each result below shows which ingredient is responsible. Mangoselect

Each ingredient & the kinds of drugs it affects

For each ingredient in Antiflame with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mangoselect2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Mangoselect full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Antiflame, from the product label.

Simply Best

See all Simply Best products
Name
Simply Supplements
Street Address
PO Box 1330
City
Peterborough
ZipCode
PE2 2PW
Phone Number
0800 988 0292
Pharmacist Counseling Corner

Antiflame by Simply Best: Common Questions

Does Antiflame by Simply Best interact with any medications?
Yes. Based on its ingredients, Antiflame has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Antiflame contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is mangosteen, and why is it in this product?
Mangosteen is a tropical fruit that's been used traditionally for inflammatory conditions. It's included here because research suggests it may help with gum disease (periodontitis). This product concentrates the plant material into a capsule.
Does Antiflame actually work?
Mangosteen is rated possibly effective for gum disease based on available studies. For baldness, eczema, or Alzheimer's disease—other uses sometimes mentioned—we don't have reliable evidence yet. Talk with your pharmacist about whether it fits your goals.
What side effects might I notice?
In trials, some people reported mild tiredness, headache, dizziness, and stomach symptoms like nausea, constipation, or diarrhea—though it's unclear whether mangosteen caused them. Dry throat, cough, and flu-like symptoms were also mentioned in some cases. Most people don't experience these.
Is it safe to take if I'm pregnant or breastfeeding?
No. There isn't enough safety information, and the safety data advises against supplement amounts of mangosteen during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about your individual situation.
Are there any fillers or extra ingredients?
The capsule itself is made of HPMC (a vegetarian capsule material). That's it—no other inactive ingredients beyond the mangosteen inside.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Antiflame is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Antiflame label
Go deeper

The Full Monographs Behind Antiflame’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

Antiflame's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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