Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Aplodan Ingredients & Drug Interactions

by MuscleTech

Aplodan label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Aplodan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Aplodan is a dietary supplement by MuscleTech with 2 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 263 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 1,2-Dithiolane-3-Pentanoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Aplodan by MuscleTech

Ask about any prescription or over-the-counter medication and we check it for interactions with Aplodan by MuscleTech — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Aplodan by MuscleTech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Aplodan” is listed as a grouped ingredient — the label gives one combined amount (1,010 mg) without saying how much of each component you get.

Aplodan contains 2 active ingredients. The primary one is alpha-lipoic acid (listed as 1,2-dithiolane-3-pentanoic acid on the label—it's the same compound), a naturally occurring antioxidant that your body uses to help convert food into energy.

The second ingredient, 2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid, we have no published data on; we can't tell you what role it plays in this formula. The product also contains several inactive ingredients—binders, fillers, and a coating—including microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silicon dioxide, magnesium stearate, and sucralose.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: unlock muscle size and strength.
  • We looked for evidence on: Muscle strength, muscle growth, muscle activation, strength gains.
  • The closest evidence on file: Alpha-lipoic Acid is rated "Insufficient Reliable Evidence To Rate" for Muscle strength (Natural Medicines).

Alpha-lipoic acid has possibly effective evidence for three uses: diabetic nerve pain (neuropathy), high cholesterol (hyperlipidemia), and weight management (obesity). That means some clinical studies suggest it may help, but the evidence isn't yet strong enough to call it proven.

We hold no effectiveness data on the second active ingredient, so we can't speak to what it contributes to the formula.

The evidence, ingredient by ingredient Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated in most adults. The most common side effects from oral use are headache, heartburn, nausea, and vomiting.

Some people also report dizziness or skin rash and itching. Serious side effects are rare but have been reported in case studies.

Because alpha-lipoic acid can lower blood sugar, use it under medical guidance if you're at risk for low blood sugar. The safety data advises against use during pregnancy and while breastfeeding—there isn't enough reliable information to know it's safe in those situations.

Talk with your doctor or pharmacist about personalized advice if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Alpha-lipoic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-lipoic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 263 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin)—alpha-lipoic acid may increase bleeding risk. If you're on thyroid hormone replacement, chemotherapy (alkylating agents or antitumor antibiotics), or diabetes medications, discuss this product first, as alpha-lipoic acid may affect how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Aplodan might be worth considering if you have diabetic nerve pain, high cholesterol, or want to try a supplement for weight management—and you don't take blood thinners, thyroid medication, chemotherapy, or diabetes drugs. If you're on any prescription medication, especially those, check your exact drugs with our tool before you start.

Your pharmacist can walk you through whether this fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Aplodan, straight from the product label.

Brand MuscleTech
Barcode (UPC) 631656601220
Net contents 63 Caplet(s)
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3016
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Aplodan by MuscleTech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
2 Caplet(s)
Servings per container
63
UPC/BARCODE
631656601220
IngredientAmount% DV
1,2-Dithiolane-3-Pentanoic Acid0 NP--
Aplodan1010 mg--
2-(Carbamimidoyl-Methyl-amino) Ethoxyphosphonic Acid0 NP--

Other ingredients: Microcrystaline Cellulose, Dicalcium Phosphate Anhydrous, Stearic Acid, Coating, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

The Aplodan Advantage; Unlock Muscle Size and Strengh With Aplodan, you now have in your hands the key to unlocking strength you never knew you had, and as a result, the ability to trigger more muscle growth than you ever thought possible.

2007 Covered by U.S. patent #6,136,339 and patents pending. The Aplodan trademark is owned by Aplodan Formulations Ltd. All other trademarks are owned by their respective companies and used under license.

General Statements

But to do it, you must understand the full power of Aplodan and how it takes the single greatest problem holding you back from getting as big and strong as possible - untapped dormant muscle fibers. Trigger Dormant Muscle Activation In every bundle of muscle fibers within your body, you have several clusters of muscle fibers that are dormant and don't materially function or contribute to improving muscle size. During a typical workout, you never actually stress your muscles enough to trigger growth in these dormant muscle fibers. But now, after utilizing years of research including clinical research at the University of Milan, Team MuscleTech has engineered Aplodan - the world's first and only dormant muscle fiber activator that allows you to increase muscle fiber activation by an average of 83%! It's the key to unlocking the potential for new muscle that's been locked away in your body for years! The Scientific Research Behind Aplodan Over 30 independent scientific studies have examined the multiple performance and metabolic effects of the revolutionary Aplodan complex. In just one of these studies, Aplodan was shown to increase stimulation for greater muscle fiber activation in as little as 7 days! To accurately measure the power of the Aplodan formula researchers used an isometric grip test (the widely accepted device used to measure raw power and strength). By the conclusion of the study subjects were able to achieve muscle tension thresholds that were 83% greater than baseline (1.74 vs. 3.18 mins.) proving Aplodan's potent effectiveness! In a separate battery of tests, sprinters taking Aplodan increased their speed/power by increments that would normally take years to develop! The bottom line is that Aplodan is the only supplement of its kind that gives you the ability to be strong enough in the gym to activate dormant muscle fibers! Rapid Delivery of Aplodan Designed with special rapid release technology, the Aplodan complex starts working quickly. It drives itself inside your muscle fibers affecting the internal metabolic machinery for improved muscle fiber activation. Aplodan's unique molecular structure is designed to manipulate the metabolic environment deep within muscle fibers, promoting activation, and subsequently allowing you to train with the type of intensity necessary to allow you to trigger the growth potential that lies within dormant muscle fibers. Aplodan Takes the Bodybuilding World by Storm! As a supplement with an extremely impressive history, research backing, and human clinical trials to prove its potent effects, millions of bodybuilders everywhere are now educating themselves on dormant muscle fibers and how Aplodan is the first and best way to activate them. Right on the heels of the most popular group of supplements like naNox9, GAKIC, LEUKIC, and Anator-p70, Aplodan is poised to be the biggest supplement to ever hit bodybuilding! Awaken the untapped muscular growth potential you have inside you right now and build massive size and strength the Aplodan way.

Based on Research Conducted at The University of Milan

Research and development

New!

World's 1st dormant muscle fiber activator 83% more muscle fiber activator Triggers untapped human growth potential Pharmacologically engineered to trigger dormant muscle fiber activation in 7 days Scientifically researched in over 30 independent studies

Made in the U.S.A. from international and domestic ingredients.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: (a) for the first week: take 2 servings (2 caplets) of Aplodan, 3 times daily. (b) From the second week onwards: take 1 serving (1 caplet), 3 times a daily.

Precautions

Warning: Not intended for use by persons under 18.

Do not use if pregnant or nursing. Consult a doctor before use if you have been treated for or diagnosed with, or have a family history of any medical condition or if you are using any over the counter medication(s).

Consult a medical doctor before starting any diet or exercise program. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed. Do not use if imprinted seal under cap is broken.

Storage

Store in a cool, dry place (60F to 80F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

4251US

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Aplodan by MuscleTech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Aplodan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Aplodan by MuscleTech

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container63 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aplodan

1010 mg per serving

Other (inactive) ingredients: Microcrystaline Cellulose, Dicalcium Phosphate Anhydrous, Stearic Acid, Coating, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Aplodan by MuscleTech Drug Interactions

Want to check YOUR meds against Aplodan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
263Drugs
177 Moderate 86 Minor

Ingredients driving the most interactions

1,2-Dithiolane-3-Pentanoic Acid 263

Individual Drug Interactions

The ingredients in Aplodan interact with 263 drugs. Click any drug to see the details.

1 of the 2 ingredients in Aplodan interact with drugs. Each result below shows which ingredient is responsible. 1,2-Dithiolane-3-Pentanoic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Aplodan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

1,2-Dithiolane-3-Pentanoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
1,2-Dithiolane-3-Pentanoic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Aplodan, from the product label.

MuscleTech

See all MuscleTech products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
3880 Jeffrey Blvd
City
Blasdell
State
NY
ZipCode
14219
Phone Number
1-800-246-3261
Web Address
www.MuscleTech.com
Pharmacist Counseling Corner

Aplodan by MuscleTech: Common Questions

Does Aplodan by MuscleTech interact with any medications?
Yes. Based on its ingredients, Aplodan has a known interaction with 263 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Aplodan contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood thinners like warfarin?
Not without checking with your pharmacist or doctor first. Alpha-lipoic acid may increase your bleeding risk when combined with blood thinners. The interaction is Moderate severity, so your prescriber needs to weigh the benefit against the risk for your situation.
What are the most common side effects?
Headache, heartburn, nausea, and vomiting are the most often reported. Some people also experience dizziness or a skin rash. Most people tolerate it well, but if these bother you, stop and tell your pharmacist.
Can I take this while pregnant or breastfeeding?
The safety data advises against it—there isn't enough reliable information to know either way. Talk with your doctor or pharmacist about your specific situation before starting; they can give you personalized advice based on your health.
Does alpha-lipoic acid actually lower blood sugar?
Small studies suggested it might, but larger clinical trials in people with diabetes showed no meaningful effect. That said, it carries a Minor-severity theoretical risk of low blood sugar if you're on diabetes drugs, so mention it to your doctor if you use them.
What is alpha-lipoic acid, and why is it in this product?
Alpha-lipoic acid is an antioxidant your body naturally makes—it helps turn food into energy. Clinical evidence suggests it may help with diabetic nerve pain, high cholesterol, and weight management, which is why it's included here.
Is this safe to take with thyroid medication?
There's a Moderate-severity theoretical concern. Animal research suggests alpha-lipoic acid may reduce how well your body converts thyroid hormone into its active form. Check with your prescriber before starting if you take levothyroxine or other thyroid drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Aplodan label
Go deeper

The Full Monographs Behind Aplodan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

Aplodan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 48 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
  20. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, pla
  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
  22. Volchegorskii I. A., Rassokhina L. M., Koliadich M. I., Alekseev M. I. [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients]. Eksp Klin Farmakol 2011;74(11):
  23. Cavalcanti D. R., da Silveira F. R. Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial. J Oral Pathol Med 2009;38(3):254-261. PubMed
  24. Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med 2011;124( PubMed
  25. Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O. Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream. Contact Dermatitis 2006;55(1):56-57.
  26. Tang, J., Wingerchuk, D. M., Crum, B. A., Rubin, D. I., and Demaerschalk, B. M. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007;13(3):164-167. PubMed
  27. Hegazy SK, Tolba OA, Mostafa TM, Eid MA, El-Afify DR. Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes. Rev Diabet Stud 2013;10(1):58-67. PubMed
  28. Huang Z, Wan X, Liu J, et al. Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant a-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus. Diabetes Technol Ther 201
  29. Sarezky D, Raquib AR, Dunaief JL, Kim BJ. Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye. Clin Ophthalmol. 2016 Sep 29;10:1899-1903. PubMed
  30. Boriani F, Granchi D, Roatti G, Merlini L, Sabattini T, Baldini N. Alpha-lipoic acid after median nerve decompression at the carpal tunnel: a randomized controlled trial. J Hand Surg Am. 2017 Apr;42(4):236-42. PubMed
  31. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  32. Murray GL, Colombo J. (r)Alpha lipoic acid is a safe, effective pharmacologic therapy of chronic orthostatic hypotension associated with low sympathetic tone. Int J Angiol. 2019;28(3):188-193. PubMed
  33. Bobe G, Michels AJ, Zhang WJ, et al. A randomized controlled trial of long-term (R)-α-lipoic acid supplementation promotes weight loss in overweight or obese adults without altering baseline elevated plasma triglyceride concentrations. J Nutr. 2020:
  34. Passiatore M, Perna A, De-Vitis R, Taccardo G. The use of alfa-lipoic acid-R (ALA-R) in patients with mild-moderate carpal tunnel syndrome: A randomised controlled open label prospective study. Malays Orthop J. 2020;14(1):1-6. PubMed
  35. El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA. Oral alpha lipoic acid treatment for symptomatic diabetic peripheral neuropathy: A randomized double-blinded placebo-controlled study. Endocr Metab Immune Disord Drug Targets. 2020. PubMed
  36. Kim BJ, Hunter A, Brucker AJ, et al. Orally administered alpha lipoic acid as a treatment for geographic atrophy: A randomized clinical trial. Ophthalmol Retina. 2020;4(9):889-898. PubMed
  37. Derosa G, D'Angelo A, Preti P, Maffioli P. Safety and efficacy of alpha lipoic acid during 4 years of observation: A retrospective, clinical trial in healthy subjects in primary prevention. Drug Des Devel Ther. 2020;14:5367-5374.
  38. Sun Y, Guan X, Wang H, et al. Randomized clinical trial of combined therapy with oral a-lipoic acid and NB-UVB for nonsegmental stable vitiligo. Dermatol Ther. 2021;34(1):e14610.
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See these in context on the Alpha-lipoic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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