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Dietary supplement

B2-400 Ingredients & Drug Interactions

by Bio-Tech Pharmacal

B2-400 label
See full label image
Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking B2-400 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

B2-400 is a dietary supplement by Bio-Tech Pharmacal with 1 active ingredient. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against B2-400 by Bio-Tech Pharmacal

Ask about any prescription or over-the-counter medication and we check it for interactions with B2-400 by Bio-Tech Pharmacal — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of B2-400 by Bio-Tech Pharmacal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

B2-400 is a straightforward supplement: one active ingredient, riboflavin (also called vitamin B2), at 400 milligrams per capsule. Riboflavin is an essential B vitamin your body needs to convert food into energy and support cell health.

The capsule also contains microcrystalline cellulose, gelatin, and silica as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Riboflavin product and its label doesn't state a use — see Riboflavin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts on file don't include effectiveness ratings for riboflavin, so we can't tell you from our data what conditions or benefits it may support. If you're considering B2-400 for a specific reason, talk it over with your doctor or pharmacist—they can advise whether riboflavin is right for your situation.

The evidence, ingredient by ingredient Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is very well tolerated at recommended doses; any excess your body doesn't use is cleared through your urine. The most common side effects are dose-related nausea and bright yellow urine—both harmless.

Rarely, diarrhea or increased urination has been reported at higher doses like 400 mg daily. Riboflavin is needed during pregnancy and breastfeeding and is generally safe at normal amounts, but if you're pregnant, nursing, or considering high-dose supplementation, check with your provider first.

Side effects, ingredient by ingredient Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take tetracycline antibiotics (doxycycline, minocycline, and others in that class), check with your pharmacist before starting B2-400. Riboflavin may reduce how well these antibiotics work, though this hasn't been confirmed in people.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

B2-400 is a high-dose riboflavin supplement for anyone whose doctor or nutritionist has recommended B2 support. If you take tetracycline antibiotics, double-check with your pharmacist before starting—the two may interact.

It's generally well tolerated, but talk it over with your own doctor or pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about B2-400, straight from the product label.

Brand Bio-Tech Pharmacal
Barcode (UPC) 705105095905
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 217127
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Halal, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for B2-400 by Bio-Tech Pharmacal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
705105095905
IngredientAmount% DV
Riboflavin400 mg30770%

Other ingredients: Microcrystalline Cellulose, Gelatin Capsule, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of the reach of children.

Safety sealed for your protection.

Storage

Store tightly closed in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule per day or as directed by a healthcare professional.

Formulation

Contains No: Dairy, egg, fish, shellfish, nuts, wheat, gluten, soy, sugar, yeast, artificial preservatives or colors.

Gluten free Non GMO

cGMP Current Good Manufacturing Practice

Formula

Halal certified.

Riboflavin

General Statements

Energy = Health

PNR Over 100 Partners in Research

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

cGMP Current Good Manufacturing Practice

ISWA Halal

Made in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

B2-400 by Bio-Tech Pharmacal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

B2-400 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in B2-400 by Bio-Tech Pharmacal

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Riboflavin

Interacts with
20 drugs
400 mg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin Capsule, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

B2-400 by Bio-Tech Pharmacal Drug Interactions

Want to check YOUR meds against B2-400?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Riboflavin 20

Individual Drug Interactions

The ingredients in B2-400 interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in B2-400 interact with drugs. Each result below shows which ingredient is responsible. Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in B2-400 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for B2-400, from the product label.

Bio-Tech Pharmacal

See all Bio-Tech Pharmacal products
Name
Bio-Tech
City
Fayetteville
State
AR
ZipCode
72704
Phone Number
1-800-345-1199
Web Address
www.BioTechPharmacal.com
Pharmacist Counseling Corner

B2-400 by Bio-Tech Pharmacal: Common Questions

Does B2-400 by Bio-Tech Pharmacal interact with any medications?
Yes. Based on its ingredients, B2-400 has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
B2-400 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will B2-400 turn my urine bright yellow?
Yes—at this 400 mg dose, bright yellow urine is a normal side effect. It's harmless; your body is just getting rid of excess riboflavin in your urine.
Can I take B2-400 if I'm pregnant or breastfeeding?
Riboflavin is needed during pregnancy and breastfeeding at normal amounts and is generally safe at recommended doses. If you're considering a high-dose supplement like B2-400, check with your provider first for personalized advice.
What are the side effects?
Most people tolerate it well. The most common side effect is dose-related nausea. Rarely, diarrhea or increased urination may occur at the 400 mg dose.
Is riboflavin the only ingredient?
Yes—riboflavin is the single active ingredient. The capsule also contains microcrystalline cellulose, gelatin, and silica to hold it together.
What does riboflavin actually do?
Riboflavin is a B vitamin your body needs to turn food into energy and support normal cell function. It's an essential nutrient, though the specific benefits of supplementing beyond recommended amounts aren't detailed in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if B2-400 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

B2-400 label
Go deeper

The Full Monographs Behind B2-400’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

B2-400's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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