Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

BCAA2 Intra-Workout Lunar Pop Ingredients & Drug Interactions

by NorthBound Nutrition

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

BCAA2 Intra-Workout Lunar Pop is a dietary supplement by NorthBound Nutrition with 5 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine, Taurine, Coconut Water, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 7 active ingredients.
  • “Absorption Enhancer” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Endurance Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Branched-Chain Amino Acids, Instantized” is listed as a grouped ingredient — the label gives one combined amount (4 Gram(s)) without saying how much of each component you get.

BCAA2 Intra-Workout Lunar Pop contains 7 active ingredients designed to support exercise performance and recovery. The three branched-chain amino acids — L-Leucine, L-Isoleucine, and L-Valine — are the backbone; they're building blocks your muscles use directly during and after training.

L-Tyrosine supports mental focus and mood, while taurine aids muscle function and endurance. Bioperine (from black pepper) is included as an absorption enhancer to help your body take in these nutrients more efficiently.

Coconut water powder adds electrolytes for hydration during your workout. The product also contains inactive ingredients — maltodextrin, citric acid, natural flavors, sucralose, silica, and red beet — which serve as fillers, texture, sweetness, and color.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Phenylketonuria (PKU) — rated "Effective" (Tyrosine) (Natural Medicines).
  • On file: Congestive heart failure (CHF) — rated "Possibly Effective" (Taurine) (Natural Medicines).
  • On file: Hepatitis — rated "Possibly Effective" (Taurine) (Natural Medicines).
  • On file: Cognitive function — rated "Possibly Effective" (Tyrosine) (Natural Medicines).
  • On file: Memory — rated "Possibly Effective" (Tyrosine) (Natural Medicines).

The science is mixed. Tyrosine shows possibly effective evidence for cognitive function and memory, and it's effective for phenylketonuria (PKU), a rare genetic condition — but for athletic performance, the evidence rates as possibly ineffective.

Taurine has possibly effective evidence for congestive heart failure and hepatitis, though the data on taurine for sports performance or muscle recovery specifically isn't established in what we hold. For the BCAAs (leucine, isoleucine, valine) themselves and Bioperine's role in this formula, effectiveness data isn't on file.

Coconut water's effectiveness for any of the conditions tracked also isn't established in our data.

The evidence, ingredient by ingredient Black Pepper Taurine Coconut Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tyrosine is generally well tolerated in healthy adults, but you should talk to a healthcare provider before using it regularly. The most common side effects from trials were fatigue, headache, heartburn, and nausea — especially at higher doses.

Pregnancy and lactation safety data for tyrosine is not on file. Taurine is generally well tolerated short-term in healthy adults, though long-term safety is less certain; it appears likely safe in pregnancy and lactation.

Most common side effects are constipation, diarrhea, and indigestion. Bioperine (black pepper) is generally safe in food amounts; as a concentrated supplement, it's well tolerated orally with occasional burning aftertaste or indigestion.

Pregnancy safety is listed as likely safe, though lactation safety is less clear. Coconut is likely safe in pregnancy and lactation and generally well tolerated, though allergic reactions — including anaphylaxis — can occur in sensitive individuals.

We have no safety data on file for the three branched-chain amino acids themselves.

Side effects, ingredient by ingredient Black Pepper Taurine Coconut Tyrosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Black Pepper, Taurine, Tyrosine, Coconut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,161 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take phenytoin (Dilantin), propranolol (Inderal), theophylline, rifampin (Rifadin), or any other seizure, heart, blood pressure, antibiotic, or breathing medication, check it against the tool — Bioperine may raise its blood levels. If you're on levodopa for Parkinson's, talk to your pharmacist about separating doses from this product by at least 2 hours.

If you take thyroid hormone, high blood pressure medication, lithium, or diabetes medication, also check your specific drug before using this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

BCAA2 Intra-Workout is aimed at athletes looking to fuel performance and recovery with amino acids and electrolytes. If you take seizure medications, heart or blood pressure drugs, antibiotics, breathing medications, thyroid hormones, lithium, or diabetes medications, you need to check your specific drugs with the tool below — Bioperine and tyrosine in particular may affect how several of them work.

Talk to your pharmacist or doctor before starting this product if you're on regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BCAA2 Intra-Workout Lunar Pop, straight from the product label.

Brand NorthBound Nutrition
Barcode (UPC) 864722000294
Net contents 10.65 Ounce(s); 302 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 305272
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.55 Gram(s), 15.1 Gram(s)
Maximum serving Sizes:
7.55 Gram(s), 15.1 Gram(s)
Servings per container
20
UPC/BARCODE
864722000294
IngredientAmount% DV
Calories5 Calorie(s), 10 Calorie(s)--
Total Carbohydrates1 Gram(s), 2 Gram(s)1%, 1%
L-Leucine0 NP, 0 NP--
L-Isoleucine0 NP, 0 NP--
L-Tyrosine500 mg, 1 Gram(s)--
L-Valine0 NP, 0 NP--
Sugars1 Gram(s), 1 Gram(s)--
Bioperine2.5 mg, 5 mg--
Taurine500 mg, 1 Gram(s)--
Coconut Water, Powder500 mg, 1 Gram(s)--
Absorption Enhancer0 NP, 0 NP--
Endurance Blend0 NP, 0 NP--
Branched-Chain Amino Acids, Instantized4 Gram(s), 8 Gram(s)--
Performance Blend0 NP, 0 NP--
Focus Amplifier0 NP, 0 NP--

Other ingredients: Maltodextrin, Citric Acid, Natural Flavors, Sucralose, Silica, Red Beet

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Servings Per Container: 40/20

Notice: Product amount based on weight, not volume. Some settling may occur.

Suggested/Recommended/Usage/Directions

To ensure proper mixture, shake well before use.

Suggested use: Mix 1/2 - 1 scoop in 16-20 oz. of water; consume during exercise on training days. On non-training days, consume 1/2 scoop throughout the day.

Storage

Store in a cool, dry place.

Precautions

Warning: Only intended for use by healthy adults, 18 years and older.

Consult your physician before using this product if you are taking any medication or are under a physician's care. Not for use by women that are pregnant, trying to become pregnant, or nursing.

Discontinue use if you experience any adverse reaction to this product. Do not exceed recommended serving size or suggested use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to cure, treat, or prevent any disease.

Formulation

Made with natural sugar free flavors & colors

Focus Hydration Endurance Pump Recovery When combined with a proper exercise and nutrition program.

No banned substances No proprietary blends Sugar free

Brand IP Statement(s)

Northbound Nutrition Go further

BioPerine BioPerine is a registered trademark and patented product of Sabinsa Corporation. Northbound Nutrition Own your passion

FDA Statement of Identity

Dietary Supplement

See for yourself

BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.55 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Absorption Enhancer

0 NP per serving

Endurance Blend

0 NP per serving

Performance Blend

0 NP per serving
  • › Branched-Chain Amino Acids, Instantized

Focus Amplifier

0 NP per serving

Other (inactive) ingredients: Maltodextrin, Citric Acid, Natural Flavors, Sucralose, Silica, Red Beet. These complete the product’s ingredient list but are not active constituents.

Interaction report

BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition Drug Interactions

Want to check YOUR meds against BCAA2 Intra-Workout Lunar Pop?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,160Drugs
1,117 Moderate 43 Minor

Ingredients driving the most interactions

Bioperine 1,019
Taurine 173

Each ingredient & the kinds of drugs it affects

For each ingredient in BCAA2 Intra-Workout Lunar Pop with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D

Coconut Water, Powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for BCAA2 Intra-Workout Lunar Pop, from the product label.

NorthBound Nutrition

See all NorthBound Nutrition products
Name
Northbound Nutrition
City
Granbury
State
TX
ZipCode
76048
Web Address
www.northboundnutrition.com
Pharmacist Counseling Corner

BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition: Common Questions

Does BCAA2 Intra-Workout Lunar Pop by NorthBound Nutrition interact with any medications?
Yes. Based on its ingredients, BCAA2 Intra-Workout Lunar Pop has a known interaction with 1,160 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BCAA2 Intra-Workout Lunar Pop contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are BCAAs and what do they do?
BCAAs — leucine, isoleucine, and valine — are three essential amino acids your body can't make on its own. Your muscles use them directly for building and repair, especially during and after exercise. This product delivers them as an intra-workout formula to support training.
Is it safe to take this while breastfeeding?
Tyrosine's safety while breastfeeding isn't established in our data, so you'd need to talk with your doctor or pharmacist. Taurine and coconut appear likely safe, and the BCAAs are amino acids your body naturally produces, but we don't have specific breastfeeding data on those either. Get personalized advice from your healthcare provider.
Does Bioperine mean this product has no fillers?
No — Bioperine is an active ingredient (an absorption enhancer), not a filler claim. The product does contain inactive ingredients like maltodextrin, citric acid, and silica, which are standard fillers and binders in powdered supplements.
Can I take this if I'm on thyroid medication?
Tyrosine in this product might add to the effects of thyroid hormone medications. You should check with your pharmacist or doctor before taking it — they can advise whether it's safe for your specific situation or if you need to adjust timing.
What are the most common side effects?
From tyrosine, the most common are fatigue, headache, heartburn, and nausea — usually at higher doses. From taurine, constipation, diarrhea, and indigestion. From Bioperine, a burning aftertaste or mild indigestion. Most people tolerate it well, but if you notice any of these, dial back your dose or talk to your pharmacist.
Is this safe for someone with a coconut allergy?
No — this product contains coconut water powder. Coconut can trigger allergic reactions ranging from hives to anaphylaxis in sensitive people. If you have a tree nut or coconut allergy, avoid this product entirely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BCAA2 Intra-Workout Lunar Pop is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BCAA2 Intra-Workout Lunar Pop label
Sources

Sources & How We Checked

BCAA2 Intra-Workout Lunar Pop's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 64 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
  10. Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
  11. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
  12. Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
  13. Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
  14. Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., and Tezuka, Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. PubMed
  15. Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
  16. Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
  17. Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
  18. Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
  19. Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. PubMed
  20. Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. PubMed
  21. Aher, S., Biradar, S., Gopu, C. L., and Paradkar, A. Novel pepper extract for enhanced P-glycoprotein inhibition. J Pharm.Pharmacol. 2009;61(9):1179-1186. PubMed
  22. Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224.
  23. Marotta, R. B. and Floch, M. H. Diet and nutrition in ulcer disease. Med Clin North Am 1991;75(4):967-979. PubMed
  24. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  25. Gimenez L, Zacharisen M. Severe pepper allergy in a young child. WMJ. 2011 Jun;110(3):138-9.
  26. Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z. Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci. 2019;218:314-323. PubMed
  27. Thomas AB, Choudhary DC, Raje A, Nagrik SS. Pharmacokinetics and pharmacodynamic herb-drug interaction of piperine with atorvastatin in rats. J Chromatogr Sci 2021;59(4):371-80. PubMed
  28. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
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Taurine 21 references
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  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
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  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
  13. Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr Res 1985;19(6):578-582. PubMed
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  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
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  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

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Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
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  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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