Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Bean & Vegetable Gas Relief Ingredients & Drug Interactions

by ProCaps Laboratories

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Bean & Vegetable Gas Relief is a dietary supplement by ProCaps Laboratories with 4 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Legume Enzyme Complex, Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Bean & Vegetable Gas Relief by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Bean & Vegetable Gas Relief contains four active ingredients. Papain is an enzyme from papaya that breaks down protein.

Bromelain is a protein-digesting enzyme from pineapple. The product also includes an Alpha Enzyme Complex and a Legume Enzyme Complex (derived from calabar bean).

These are designed to help your digestive system handle gases from beans and vegetables. The capsule itself is made from gelatin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: reduce gas from beans and vegetables.
  • We looked for evidence on: Gas and bloating, Intestinal gas, Flatulence, Digestive discomfort.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).

The evidence for these ingredients isn't established in our data. Papain's effectiveness ratings show insufficient reliable evidence for cancer, dental cavities, radiation skin damage, exercise soreness, shingles, and parasitic infections.

Bromelain similarly lacks sufficient evidence for hay fever, burns, cancer, nerve damage from chemotherapy, poor circulation, and diabetes. No effectiveness ratings are on file for Alpha Enzyme Complex or calabar bean for gas relief specifically.

The evidence, ingredient by ingredient Papain Bromelain Calabar Bean

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At normal doses, papain and bromelain are generally well tolerated short-term. Papain may irritate your digestive tract or trigger allergic reactions in sensitive people — symptoms include itchy watery eyes, runny nose, sneezing, cramping, sweating, or diarrhea.

High doses of papain can rarely cause severe stomach inflammation or even perforation. Bromelain's most common side effects are diarrhea, bloating, stomach upset, and headache.

Both can cause allergic reactions. Calabar bean is toxic and should not be used — it can cause serious effects including paralysis, coma, and death, and is unsafe in pregnancy and breastfeeding.

Papain is possibly unsafe in pregnancy and lacks safety data for breastfeeding. Bromelain should be avoided in pregnancy and breastfeeding because safety data don't exist.

Side effects, ingredient by ingredient Papain Bromelain Calabar Bean

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Calabar Bean, Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 333 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check your medications before using this product, especially blood thinners like warfarin and other anticoagulants or antiplatelet drugs (Moderate severity). If you take tetracycline antibiotics or anticholinergic drugs, mention those too.

The calabar bean in this product is toxic and makes the overall safety profile a serious concern — discuss with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains potent enzymes and a toxic ingredient (calabar bean) with serious safety and interaction concerns. Do not use it if you take warfarin or other blood thinners, or anticholinergic drugs.

Even if you're not on those medications, the calabar bean component makes this product unsafe — talk to your pharmacist before considering it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bean & Vegetable Gas Relief, straight from the product label.

Brand ProCaps Laboratories
Barcode (UPC) 692704
Net contents 240 Easy-To-Swallow Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 248402
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bean & Vegetable Gas Relief by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
240
UPC/BARCODE
692704
IngredientAmount% DV
Papain150 mg--
Bromelain150 mg--
Alpha Enzyme Complex30 mg--
Legume Enzyme Complex100 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use For best results, consume one or more capsules with meals as needed based upon the “gas producing” foods contained in that meal or as recommended by your physician. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle, along with a daily multi-vitamin-mineral formula. For answers to questions about the use of this product, call 800.332.7799.

Precautions

Note This product is not designed to cure or treat any gastrointestinal disease or health condition and should not be used in the presence of any gastrointestinal disease or problem.

General Statements

HSN www.HSN.com 800.944.9999 www.QVC.com 800.345.1515 Questions?/reorders? 800.800.1200 www.ProCapsLabs.com

Brand IP Statement(s)

Copyright 2020 ProCaps Labs

Formula

Natural enzyme complex

Beans Nuts Seeds Legumes Soy Cruciferous vegetables Fruit

All of us are different, but we each know the foods that can cause us gas and discomfort. Scientists have identified molecular sources of gas in these foods, and Bean and Vegetable Gas Relief targets those sources and provides natural digestive relief. Bean & Vegetable Gas Relief contains a unique blend of special enzyme complexes to break down these offending gas-producing molecules and make these healthy foods less unpleasant by helping to prevent the gas, bloating and discomfort. In addition to these important enzymes, Bean & Vegetable Gas Relief contains papain and bromelain to help support the digestion of proteins as well. Many people have difficulty enjoying some of the foods they love, but the mild, yet powerful natural enzymes in Bean & Vegetable Gas Relief are designed to return the health and pleasure of eating these foods without embarrassment and discomfort.

FDA Statement of Identity

Dietary Supplement

Formulation

All-solar manufacturing

Andrew Lessman's Bean & Vegetable Gas Relief is a mild, natural, food supplement designed to gently and effectively support and enhance your body's natural digestion of gas-causing foods. Sadly, many of the healthiest foods, such as beans, cruciferous vegetables, fruits, nuts, seeds, grains and soy, contain complex molecules that can be difficult for the body to digest, causing gas, bloating and discomfort. The resulting gastrointestinal discomfort and gas discourages us from eating these otherwise extremely healthy foods.

Contains no milk, soy, yeast, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens or manufacturing additives. Contains no additives of any kind.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Bean & Vegetable Gas Relief by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Bean & Vegetable Gas Relief by ProCaps Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
150 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bromelain

Interacts with
141 drugs
150 mg per serving

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Alpha Enzyme Complex

30 mg per serving

Legume Enzyme Complex

Interacts with
195 drugs
100 mg per serving

Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supple...

Legume Enzyme Complex monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bean & Vegetable Gas Relief by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against Bean & Vegetable Gas Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
333Drugs
122 Moderate 211 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Each ingredient & the kinds of drugs it affects

For each ingredient in Bean & Vegetable Gas Relief with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Legume Enzyme Complex1 drug type · 195 drugs

Anticholinergic Drugs

Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Physostigmine, a constituent of calabar bean, reverses the effects of belladonna and other drugs with anticholinergic activity.

Likelihood Unlikely Evidence D

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Bean & Vegetable Gas Relief, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps Laboratories
City
Henderson
State
NV
ZipCode
89011
Phone Number
800.800.1200
Web Address
ProCapsLabs.com
Pharmacist Counseling Corner

Bean & Vegetable Gas Relief by ProCaps Laboratories: Common Questions

Does Bean & Vegetable Gas Relief by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, Bean & Vegetable Gas Relief has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bean & Vegetable Gas Relief contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use if I'm pregnant or breastfeeding?
No. Papain is possibly unsafe in pregnancy, and there isn't enough safety data for bromelain in pregnancy or breastfeeding — avoid both. Calabar bean (in the Legume Enzyme Complex) is unsafe in pregnancy and while breastfeeding. Talk with your pharmacist or doctor before considering any herbal supplement during pregnancy or breastfeeding.
What are the main side effects I should watch for?
Bromelain commonly causes diarrhea, gas, stomach upset, and headache. Papain may cause allergic reactions — itchy eyes, runny nose, sneezing, cramping, or diarrhea — especially in people sensitive to it. High doses of papain can rarely cause severe stomach inflammation. Calabar bean can trigger a life-threatening condition called cholinergic crisis, with symptoms like muscle weakness, slow heart rate, confusion, and paralysis.
Does this actually help with gas from beans and vegetables?
The evidence for these ingredients isn't established in our data. We don't have effectiveness ratings showing they work for gas relief specifically.
Why is calabar bean in a gas-relief supplement?
Calabar bean is listed as part of the Legume Enzyme Complex. However, the safety data shows it's toxic and can cause serious harm, including paralysis, coma, and death — even at doses that might be found in supplements.
Can I use this with my other medications?
Only if your doctor or pharmacist confirms it's safe. This product has documented interactions with blood thinners, antiplatelet drugs, tetracycline antibiotics, and anticholinergic medications. Use the search tool on this page to check your exact medications before starting it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bean & Vegetable Gas Relief is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bean & Vegetable Gas Relief label
Sources

Sources & How We Checked

Bean & Vegetable Gas Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Calabar Bean 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

See these in context on the Calabar Bean monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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