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Dietary supplement

Beta Carotene 25,000 IU Ingredients & Drug Interactions

by Vitacost

Beta Carotene 25,000 IU label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Beta Carotene 25,000 IU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Beta Carotene 25,000 IU is a dietary supplement by Vitacost with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 387 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Beta Carotene 25,000 IU by Vitacost

Ask about any prescription or over-the-counter medication and we check it for interactions with Beta Carotene 25,000 IU by Vitacost — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Beta Carotene 25,000 IU by Vitacost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: vitamin A (as beta carotene) at 25,000 IU per dose. The remaining ingredients are inactives — soybean oil, gelatin, glycerin, purified water, yellow beeswax, lecithin, and D-alpha-tocopherol — which serve as the softgel capsule and carrier.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: vitamin A and antioxidant support.
  • We looked for evidence on: Vitamin A deficiency, Night vision, Acne, Aging skin, Wrinkled skin, Atopic dermatitis (eczema) — and 4 related terms.
  • The strongest evidence on file: Vitamin A is rated "Effective" for Vitamin A deficiency (Natural Medicines).
  • Also on file: Vitamin A is rated "Possibly Effective" for Aging skin, Night vision, Wrinkled skin.
  • Also on file: Vitamin A is rated "Possibly Ineffective" for Melanoma.

The data we hold shows vitamin A is effective for vitamin A deficiency. It's rated possibly effective for oral leukoplakia (a precancerous mouth condition), aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia (a lung condition in preemies).

For uses beyond these, the evidence in our data doesn't establish effectiveness.

The evidence, ingredient by ingredient Vitamin A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally well tolerated at recommended doses, but it builds up in your body over time, so high doses can become toxic. The tolerable upper limit for adults is 10,000 IU per day; this product at 25,000 IU exceeds that threshold and should only be used as directed by your doctor or if you're correcting a deficiency.

Serious adverse effects are rare but possible with high doses and include liver damage, a condition called pseudotumor cerebri (pressure inside the skull), and in severe cases, coma. Chronic overuse causes dry, cracked, itchy, or peeling skin; brittle nails; and hair loss.

For pregnancy and breastfeeding, the safety data advises against high-dose vitamin A supplements because they may cause birth defects, though normal dietary amounts are appropriate. Talk with your doctor or pharmacist about whether this dose is right for you, especially if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin A

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin A.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 388 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check with your doctor or pharmacist if you take retinoids like isotretinoin or tretinoin (Major interaction risk); warfarin or other blood thinners; tetracycline antibiotics such as doxycycline; or any medications known to stress the liver.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This supplement is useful if you have a vitamin A deficiency or your doctor recommends it for one of its possibly effective uses. If you take any prescription medications — especially retinoids, blood thinners, certain antibiotics, or drugs that affect the liver — you need to check with your doctor or pharmacist first.

Because this dose exceeds the daily upper limit, it shouldn't be taken long-term without professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beta Carotene 25,000 IU, straight from the product label.

Brand Vitacost
Barcode (UPC) 835003001422
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD May 22, 2015
DSLD ID 45642
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beta Carotene 25,000 IU by Vitacost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
835003001422
IngredientAmount% DV
Calories5 {Calories}--
Total Fat1 NP1%
Vitamin A25000 IU500%

Other ingredients: Soybean Oil, Gelatin, Glycerin, purified Water, yellow Beeswax, Lecithin, D-Alpha-Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

100% QUALITY GUARANTEE

Betatene(R)

General Statements

Vitacost Quality Gurantee.

~ Beta carotene is converted to vitamin A in the body ~ Carotenoids are antioxidants Why choose Vitacost Beta Carotene?

~ Extremely high quality at a great value

About Vitacost All Vitacost products are laboratory tested to meet FDA standards for identity, purity and composition. All products are tested for heavy metals, microbiology and contaminants. Vitacost products are produced in a NSF Certified facility. Freshness is guaranteed.

Formula

Natural beta carotene! Featuring Betatene(R) mixed carotenoids with beta carotene, alpha carotene, lutein, zeaxanthin and cryptoxanthin.

~ Supplies 25,000 IU of vitamin A per single-softgel serving ~ Features Betatene natural mixed carotenoids

Contains: Soy.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Disclaimer *These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Free Of Milk, eggs, peanuts, tree nuts, shellfish, fish, gluten, titanium dioxide.

Suggested/Recommended/Usage/Directions

Vitacost Beta Carotene Directions As a dietary supplement, take 1 softgel daily with food or as directed by a physician.

Storage

Store in a cool, dry place.

Precautions

Contains: Soy.

Warnings Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs, should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.

Brand IP Statement(s)

Betatene(R) is a registered trademark of Cognis Deutschland GmbH & Co.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Beta Carotene 25,000 IU by Vitacost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Beta Carotene 25,000 IU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Beta Carotene 25,000 IU by Vitacost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Vitamin A

Interacts with
387 drugs
25000 IU per serving Form: Natural Carotenoids

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Purified Water, Yellow Beeswax, Lecithin, D-Alpha-Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beta Carotene 25,000 IU by Vitacost Drug Interactions

Want to check YOUR meds against Beta Carotene 25,000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
387Drugs
9 Major 378 Moderate

Ingredients driving the most interactions

Vitamin A 387

Individual Drug Interactions

The ingredients in Beta Carotene 25,000 IU interact with 387 drugs. Click any drug to see the details.

1 of the 1 ingredient in Beta Carotene 25,000 IU interact with drugs. Each result below shows which ingredient is responsible. Vitamin A

Each ingredient & the kinds of drugs it affects

For each ingredient in Beta Carotene 25,000 IU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Beta Carotene 25,000 IU, from the product label.

Vitacost

See all Vitacost products
Name
Vitacost
Pharmacist Counseling Corner

Beta Carotene 25,000 IU by Vitacost: Common Questions

Does Beta Carotene 25,000 IU by Vitacost interact with any medications?
Yes. Based on its ingredients, Beta Carotene 25,000 IU has a known interaction with 387 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beta Carotene 25,000 IU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this dose of vitamin A safe to take every day?
This product contains 25,000 IU, which exceeds the recommended daily upper limit of 10,000 IU for adults. It should not be taken daily long-term unless your doctor or pharmacist directs you to do so — for example, to correct a deficiency. High-dose, long-term use can cause vitamin A to build up and become toxic.
What happens if I take too much vitamin A?
Chronic overuse causes symptoms like dry, cracked, itchy skin; hair loss; and brittle nails. In rare severe cases, very high doses can damage the liver, raise pressure inside the skull, and cause headache, blurred vision, or dizziness. Children are especially vulnerable to acute toxicity.
Can I take this while pregnant or breastfeeding?
High-dose vitamin A supplements may cause birth defects and should be avoided during pregnancy. The safety data rates this as possibly unsafe. Normal dietary amounts of vitamin A are appropriate, but talk with your doctor or pharmacist about whether this supplement dose is right for you if you're pregnant or nursing.
Does this product actually work for skin or anti-aging?
Vitamin A is rated possibly effective for aging skin in our data, meaning there is some evidence but it's not definitive. Results vary by person. Always check with your doctor before using high-dose supplements for skin, especially since vitamin A toxicity itself can damage your skin.
What's the difference between this supplement and the vitamin A in my multivitamin?
This product delivers 25,000 IU per dose — well above the daily safe limit — and is intended for specific therapeutic purposes like correcting a deficiency. A typical multivitamin contains a much smaller amount designed for daily maintenance. Never combine high-dose supplements like this with a multivitamin without checking with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Beta Carotene 25,000 IU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beta Carotene 25,000 IU label
Go deeper

The Full Monographs Behind Beta Carotene 25,000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph →
Sources

Sources & How We Checked

Beta Carotene 25,000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
  22. Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
  23. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
  24. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
  25. Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
  26. Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
  27. Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
  28. Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
  29. Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
  30. Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
  31. Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed

See these in context on the Vitamin A monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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