Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Big Noise Icy Lemonade Ingredients & Drug Interactions

by Redcon1

Big Noise Icy Lemonade label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Big Noise Icy Lemonade against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Big Noise Icy Lemonade is a dietary supplement by Redcon1 with 8 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 1,367 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola Root Extract, Beet Root Extract, Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Big Noise Icy Lemonade by Redcon1

Ask about any prescription or over-the-counter medication and we check it for interactions with Big Noise Icy Lemonade by Redcon1 — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Big Noise Icy Lemonade by Redcon1

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Big Noise Icy Lemonade contains 8 active ingredients. Glycerol Monostearate and Betaine Anhydrous (BetaPower) are osmotic compounds that may support hydration and athletic performance.

Beet Root Extract provides nitrates and antioxidants. Choline and L-Alpha Glyceryl Phosphoryl Choline (alpha-GPC) are brain-health compounds involved in acetylcholine production.

Rhodiola Root Extract is an adaptogenic herb traditionally used for stress and energy. Huperzine A is a purified alkaloid that inhibits an enzyme involved in acetylcholine breakdown.

The product also contains inactive ingredients—citric acid, flavoring, sucralose, silica, salt, and malic acid—which are fillers, sweeteners, and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: pre-workout pump and mental focus.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Cognitive function, Memory, Age-related cognitive decline — and 4 related terms.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beet is rated "Possibly Effective" for Athletic performance, Exercise-induced muscle soreness.
  • Also on file: Choline is rated "Possibly Ineffective" for Athletic performance.

The evidence for this product's ingredients is mixed and often limited. Glycerol has possibly effective evidence for athletic performance.

Betaine anhydrous (BetaPower) shows possibly effective evidence for high homocysteine levels but lacks reliable evidence for most other uses listed. Beet Root Extract is possibly effective for athletic performance and exercise-induced muscle soreness.

Huperzine A is possibly effective for Alzheimer's disease, though most other cognitive claims lack established evidence. Choline, alpha-GPC, and Rhodiola do not have sufficient reliable evidence for most of their proposed uses—the data we hold rates them as insufficient evidence to rate.

This is a pre-workout or energy formula, but we don't hold effectiveness data specifically for that purpose.

The evidence, ingredient by ingredient Glycerol Agmatine Betaine Anhydrous Beet Choline Alpha-gpc Rhodiola Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at normal doses, but several come with caveats. Glycerol can cause bloating, nausea, diarrhea, dizziness, and headache, especially at high doses, and may cause dehydration.

Agmatine, betaine, and Rhodiola show short-term tolerance but lack long-term safety data in humans. Beet Root Extract is safe as a food but safety data on concentrated supplements is limited.

Huperzine A is a pharmacologically active compound and can cause dose-dependent cholinergic side effects—blurred vision, constipation, diarrhea, dizziness, nausea, sweating, vomiting—and has rarely been associated with stroke. Alpha-GPC use for at least 2 months has been associated with an elevated stroke risk compared to non-users.

Choline at doses above 3.5 grams daily can cause nausea, vomiting, salivation, and a fishy body odor. Pregnancy and breastfeeding safety is not established for most ingredients—Choline is rated likely safe in pregnancy if dosed appropriately under guidance, but Agmatine, Rhodiola, alpha-GPC, and Huperzine A should be avoided during pregnancy and lactation due to insufficient safety data.

Side effects, ingredient by ingredient Glycerol Agmatine Betaine Anhydrous Beet Choline Alpha-gpc Rhodiola Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Beet, Choline, Huperzine A, Rhodiola, Alpha-gpc, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,368 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against blood pressure drugs and diabetes medications (Moderate severity, from Agmatine and Rhodiola), liver enzyme substrates especially CYP3A4 drugs (Moderate to Minor, from Beet and Rhodiola), anticholinergic and cholinergic medications (Moderate, from Huperzine A, Choline, and alpha-GPC), and immunosuppressants (Moderate, from Rhodiola). These are the medication TYPES most likely affected; run your exact medications through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Big Noise Icy Lemonade is a multi-ingredient pre-workout formula with significant drug interactions, especially with blood pressure and diabetes medications and drugs metabolized by liver enzymes. If you take any prescription medications or have blood pressure or blood sugar concerns, check this product against your specific drugs using the tool on this page before starting.

People pregnant or breastfeeding should avoid this product or discuss it first with their doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Big Noise Icy Lemonade, straight from the product label.

Brand Redcon1
Barcode (UPC) 810044574791
Net contents 11.38 Ounce(s); 322.5 Gram(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 300127
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Big Noise Icy Lemonade by Redcon1, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10.75 Gram(s)
Maximum serving Sizes:
10.75 Gram(s)
Servings per container
30
UPC/BARCODE
810044574791
IngredientAmount% DV
Glycerol Monostearate3 Gram(s)--
Agmatine Sulfate1 Gram(s)--
BetaPower2.5 Gram(s)--
Beet Root Extract1 Gram(s)--
Choline250 mg45%
L-Alpha Glyceryl Phosphoryl Choline300 mg--
Rhodiola Root Extract200 mg--
Huperzine A200 mcg--

Other ingredients: Citric Acid, Natural & Artificial Flavors, Sucralose, Silica, Salt, Malic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

The objective: Non-stimulant preworkout pump with the power of nootropics. The combination brings massive pumps with intense mental clarity and focus.

Pump Pump up the volume, bring the noise

Blood flow/pumps Increase blood oxygen Mental focus

The objective: Non-stimulant preworkout pump with the power of nootropics.

Suggested/Recommended/Usage/Directions

Big Noise Suggested Use: To maximize pre-workout pumps and muscular volume, mix (1) scoop with 4-6 ounces of water 30 minutes prior to training. Do not exceed (1) scoop per day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Nutravigilance Verified Supplement Safety Solutions

FDA Statement of Identity

Dietary Supplement

Formula

Icy Lemonade naturally and artificially flavored

Precautions

Warning: This product is intended to be consumed by healthy adults 18 years of age or older. Keep out of reach of children.

Do not use if you are pregnant, nursing, taking any prescription or over-the-counter medications, or if you have or suspect you may have a medical condition.

As with any dietary supplement, consult a healthcare professional before using this product. Discontinue 2 weeks prior to surgery. Immediately discontinue use and consult a healthcare professional if you experience any adverse reactions.

Storage

Store at 59-86 degrees F (15-30 degrees C). Protect from light and moisture.

General Statements

Product does not completely fill container. Settling occurs in shipping. YouTube Facebook Instagram Twitter

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Big Noise Icy Lemonade by Redcon1 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Big Noise Icy Lemonade label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Big Noise Icy Lemonade by Redcon1

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size10.75 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycerol Monostearate

No known
interactions
3 Gram(s) per serving

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

Glycerol Monostearate monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
1 Gram(s) per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

BetaPower

No known
interactions
2.5 Gram(s) per serving Form: Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

BetaPower monograph & interactions

Beet Root Extract

Interacts with
861 drugs
1 Gram(s) per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet Root Extract monograph & interactions

Choline

Interacts with
16 drugs
250 mg per serving Form: CDP-Choline

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

L-Alpha Glyceryl Phosphoryl Choline

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

L-Alpha Glyceryl Phosphoryl Choline monograph & interactions

Rhodiola Root Extract

Interacts with
1,271 drugs
200 mg per serving Form: Rhodiola rosea Root Extract

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola Root Extract monograph & interactions

Huperzine A

Interacts with
219 drugs
200 mcg per serving Form: Huperzia serrata

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Other (inactive) ingredients: Citric Acid, Natural & Artificial Flavors, Sucralose, Silica, Salt, Malic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Big Noise Icy Lemonade by Redcon1 Drug Interactions

Want to check YOUR meds against Big Noise Icy Lemonade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,367Drugs
1,195 Moderate 172 Minor

Ingredients driving the most interactions

Rhodiola Root Extract 1,271
Beet Root Extract 861
Agmatine Sulfate 258
Huperzine A 219
Choline 16

Individual Drug Interactions

The ingredients in Big Noise Icy Lemonade interact with 1,367 drugs. Click any drug to see the details.

6 of the 8 ingredients in Big Noise Icy Lemonade interact with drugs. Each result below shows which ingredient is responsible. Rhodiola Root Extract Beet Root Extract Agmatine Sulfate Huperzine A Choline L-Alpha Glyceryl Phosphoryl Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Big Noise Icy Lemonade with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola Root Extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola Root Extract full monograph & interactions

Beet Root Extract3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet Root Extract full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions

L-Alpha Glyceryl Phosphoryl Choline1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
L-Alpha Glyceryl Phosphoryl Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Big Noise Icy Lemonade, from the product label.

Redcon1

See all Redcon1 products
Name
Redcon1, LLC
Street Address
701 Park of Commerce Blvd., Suite 101
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1(855)733-2661
Web Address
www.Redcon1.com
Pharmacist Counseling Corner

Big Noise Icy Lemonade by Redcon1: Common Questions

Does Big Noise Icy Lemonade by Redcon1 interact with any medications?
Yes. Based on its ingredients, Big Noise Icy Lemonade has a known interaction with 1,367 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Big Noise Icy Lemonade contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Huperzine A and what does it do in this product?
Huperzine A is a purified compound derived from club moss that works by slowing the breakdown of acetylcholine, a brain chemical involved in memory and focus. It's included in this formula for potential cognitive support, though it's a pharmacologically active ingredient and not just a nutrient—it can cause real side effects like nausea, diarrhea, blurred vision, and nausea, especially at higher doses.
Can I take this if I'm pregnant or breastfeeding?
No. Most of the ingredients in this product—Agmatine, Rhodiola, alpha-GPC, and Huperzine A—lack enough safety data during pregnancy and breastfeeding, and the product facts advise against use. Choline is rated likely safe during pregnancy if dosed properly under medical guidance, but this formula is not recommended overall. Talk to your doctor or pharmacist before use.
Why does the interaction list mention so many medications?
Several ingredients here—Beet Root Extract, Rhodiola, and Huperzine A—interact with liver enzymes and pathways that affect how your body breaks down many different drugs. One enzyme alone (CYP3A4) is involved in metabolizing hundreds of medications, so a single ingredient can theoretically affect many of them. That's why we list the total count and why you should check your specific drugs.
What side effects might I experience from taking this?
The most common reported side effects are gastrointestinal—nausea, diarrhea, bloating, vomiting—plus dizziness and headache, depending on which ingredients cause your body to react. Glycerol and high-dose choline can cause fishy body odor. Huperzine A can cause blurred vision and cholinergic symptoms. Beet Root Extract commonly causes red or black stools, which is harmless but can be alarming.
Is this product safe to use long-term?
The data we hold doesn't fully support long-term use. Most ingredients are studied short-term only, and long-term safety in humans is not well established for Agmatine, Rhodiola, and alpha-GPC. Huperzine A use for 2 months or longer has been associated with an elevated stroke risk. Talk to your doctor if you plan to use this regularly.
Does this contain any fillers?
Yes. The inactive ingredients—citric acid, flavoring, sucralose, silica, salt, and malic acid—are excipients used for taste, texture, and shelf stability. These are standard in powder supplements and are not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Big Noise Icy Lemonade label
Go deeper

The Full Monographs Behind Big Noise Icy Lemonade’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Big Noise Icy Lemonade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
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Agmatine 3 references
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Betaine Anhydrous 11 references
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See these in context on the Betaine Anhydrous monograph →

Beet 14 references
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Choline 14 references
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  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
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See these in context on the Choline monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
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See these in context on the Alpha-gpc monograph →

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
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Huperzine A 13 references
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  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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