Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Bio-Lutein Ingredients & Drug Interactions

by Cyto-Matrix

Bio-Lutein label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio-Lutein against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bio-Lutein is a dietary supplement by Cyto-Matrix with 3 active ingredients. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bio-Lutein by Cyto-Matrix

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio-Lutein by Cyto-Matrix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio-Lutein by Cyto-Matrix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Bio-Lutein contains three active carotenoid ingredients: zeaxanthin, meso-zeaxanthin, and lutein. These are naturally occurring plant pigments that concentrate in your eyes, particularly in a part of the retina called the macula.

The product also contains a few inactive ingredients — natural tocopherols (a form of vitamin E), safflower and sunflower oils, lecithin, gelatin, glycerin, beeswax, and purified water — to hold the softgel capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: improve macular pigment optical density and eye health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Cataracts, Asthenopia (eye strain), Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Zeaxanthin and meso-zeaxanthin are possibly effective for age-related macular degeneration (AMD), the leading cause of vision loss in older adults. Lutein is also possibly effective for AMD and for cataracts.

The evidence isn't yet strong enough to rate either ingredient for cognitive decline, Alzheimer disease, asthma, or several other conditions — there's either not enough research or the studies done so far aren't reliable enough to say. For retinitis pigmentosa, retinopathy of prematurity, necrotizing enterocolitis, and bronchopulmonary dysplasia, lutein appears to be ineffective.

The evidence, ingredient by ingredient Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three active ingredients are generally well tolerated at typical supplement doses, and lutein doses up to 20 mg daily have shown no adverse effects in trials. For pregnancy and breastfeeding, the data is limited.

Zeaxanthin and meso-zeaxanthin are rated likely safe in pregnancy and lactation, but concentrated supplement doses aren't well studied — food sources are fine, so talk with your doctor or pharmacist before taking this product if you're pregnant or nursing. Lutein is naturally present in breast milk and is rated likely safe, but again, higher supplement doses haven't been well studied, so use caution and check with your healthcare provider.

Side effects, ingredient by ingredient Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs — insulin, metformin, sulfonylureas, or others that lower blood sugar — check your specific medications before starting Bio-Lutein. The zeaxanthin and meso-zeaxanthin in this product carry a Moderate interaction risk for low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bio-Lutein may be worth trying if you're concerned about age-related macular degeneration or cataracts — the evidence is solid enough to call it possibly effective. If you take any blood sugar medication, check with your pharmacist first; the zeaxanthin in this product might lower your blood sugar further.

Talk to your pharmacist if you're pregnant, nursing, or taking any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio-Lutein, straight from the product label.

Brand Cyto-Matrix
Barcode (UPC) 871740001301
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320186
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio-Lutein by Cyto-Matrix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
871740001301
IngredientAmount% DV
Zeaxanthin2 mg--
Meso-Zeaxanthin2 mg--
Lutein20 mg--

Other ingredients: Tocopherols, Natural, Safflower Oil, Sunflower Oil, Sunflower Lecithin, Gelatin, Glycerin, Yellow Beeswax, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Made in Canada

Indications: clinically proven to help improve macular pigment optical density, which helps protect the retina by filtering out damaging blue light. Helps to support eye health in conditions such as cataracts and age-related macular degeneration, and protect the eyes against oxidative damage. Helps improve contrast sensitivity, visual acuity, and glare recovery.

GMO, gluten and dairy free.

Formula

Bio-Lutein with Zeaxanthin & Meso-Zeaxathin

Lutemax2020 Lutein & Zeaxanthin

General Statements

NPN 80088829

Suggested/Recommended/Usage/Directions

Directions: Adults - Take 1 softgel per day or as directed by a healthcare professional.

Precautions

Warnings: Do not use if safety seal is broken.

Consult a healthcare professional prior to use, especially if you are pregnant or breastfeeding.

Known adverse reactions: Do not use if you are allergic to plants of the Asteraceae/Compositae/Daisy family.

Brand IP Statement(s)

Lutemax2020 is a registered trademark of OmniActive Health Technologies Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio-Lutein by Cyto-Matrix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio-Lutein label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio-Lutein by Cyto-Matrix

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zeaxanthin

Interacts with
86 drugs
2 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Meso-Zeaxanthin

Interacts with
86 drugs
2 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Meso-Zeaxanthin monograph & interactions

Lutein

No known
interactions
20 mg per serving Form: Lutemax 2020

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Other (inactive) ingredients: Tocopherols, Natural, Safflower Oil, Sunflower Oil, Sunflower Lecithin, Gelatin, Glycerin, Yellow Beeswax, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio-Lutein by Cyto-Matrix Drug Interactions

Want to check YOUR meds against Bio-Lutein?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Bio-Lutein interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Bio-Lutein interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio-Lutein with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio-Lutein, from the product label.

Cyto-Matrix

See all Cyto-Matrix products
Name
Cyto-Matrix
Street Address
70 North Wind Place
City
Toronto
State
ON
ZipCode
M1S 3R5
Web Address
cytomatrix.ca
Pharmacist Counseling Corner

Bio-Lutein by Cyto-Matrix: Common Questions

Does Bio-Lutein by Cyto-Matrix interact with any medications?
Yes. Based on its ingredients, Bio-Lutein has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio-Lutein contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is zeaxanthin, and why is it in this product?
Zeaxanthin is a plant pigment (carotenoid) that naturally collects in your eyes. It's included here because research shows it's possibly effective for age-related macular degeneration, a common eye condition as you get older.
What's the difference between zeaxanthin, meso-zeaxanthin, and lutein?
They're all carotenoid plant pigments that concentrate in the retina of the eye. Lutein and zeaxanthin are the two most abundant ones in your macula — the part of the retina you use for sharp vision. Meso-zeaxanthin is another form of zeaxanthin.
Can I take Bio-Lutein if I'm pregnant?
All three ingredients are rated likely safe in pregnancy, but concentrated supplement doses haven't been well studied — food sources are fine. Talk with your doctor or pharmacist before starting, since they know your personal health picture best.
Will this help my cataracts?
Lutein is possibly effective for cataracts, so there's some evidence it may help. Zeaxanthin and meso-zeaxanthin don't have established evidence for cataracts. Your eye doctor is the best person to discuss whether this supplement fits into your eye care plan.
Are there any side effects?
The ingredients are generally well tolerated. Lutein at doses up to 20 mg daily has not caused adverse effects in trials. No adverse effects are documented for zeaxanthin or meso-zeaxanthin at typical supplement amounts.
Does this product contain any fillers?
It contains several inactive ingredients — natural tocopherols, safflower oil, sunflower oil, lecithin, gelatin, glycerin, beeswax, and purified water — which serve as the capsule and carrier for the active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio-Lutein label
Go deeper

The Full Monographs Behind Bio-Lutein’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Bio-Lutein's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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