Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Bio.Me IB + Ingredients & Drug Interactions

by Invivo

Bio.Me IB + label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio.Me IB + against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bio.Me IB + is a dietary supplement by Invivo with 3 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. subtilis Rosell-179. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bio.Me IB + by Invivo

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio.Me IB + by Invivo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio.Me IB + by Invivo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

Bio.Me IB + has 3 active probiotic ingredients: IBacillus+ Probiotics, E. faecium Rosell-26, and B. subtilis Rosell-179. These are live beneficial bacteria intended to support digestive health.

The product also contains several inactive ingredients—potato starch, magnesium stearate, ascorbic acid, and hydroxypropyl methylcellulose—that serve as binders and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: clinically researched probiotics for gut microbiome.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia, Flatulence, and more.

B. subtilis Rosell-179 is rated possibly effective for antibiotic-associated diarrhea (diarrhea that happens after taking antibiotics). For other uses listed in our data—athletic performance, cirrhosis support, general constipation, eczema, and diabetes—the evidence isn't established well enough to rate.

The effectiveness of the other two probiotic ingredients in this product isn't established in the data we hold.

The evidence, ingredient by ingredient Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B. subtilis Rosell-179 is generally well tolerated in healthy adults, though quality and safety can vary by product and strain. One trial participant reported a headache, and diarrhea has been reported rarely.

There isn't enough safety data overall, so you should check with your doctor before use, especially if you have a weakened immune system. Pregnancy and lactation safety data aren't on file for these ingredients—talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, talk with your pharmacist or doctor before starting Bio.Me IB +. Taking them together could reduce how well the probiotic works.

We couldn't check the other two probiotic ingredients in this product, so mention all three to your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic might help if you're dealing with antibiotic-associated diarrhea and your doctor thinks it's appropriate. If you take antibiotics, space them apart from this product—don't take them at the same time.

Because the full safety profile isn't well established, check with your own doctor or pharmacist before starting, especially if you have a compromised immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio.Me IB +, straight from the product label.

Brand Invivo
Barcode (UPC) 7451254648310
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 259870
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio.Me IB + by Invivo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
7451254648310
IngredientAmount% DV
IBacillus+ Probiotics0 NP--
E. faecium Rosell-260 NP--
B. subtilis Rosell-1790 NP--

Other ingredients: Potato Starch, Magnesium Stearate, Ascorbic Acid, Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formulation

Clinically researched probiotics for the gut microbiome

GMO-free Gluten-free

Vegetarian

Storage

Shelf-stable

Store in the original packaging, under 25 degrees C, in a dry place.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule per day. Do not exceed the recommended dose, unless advised by your healthcare professional.

Precautions

Do not use if immunocompromised or allergic to any of the ingredients.

Food supplements are not a substitute for a varied and balanced diet or lifestyle.

Keep out of reach of children.

Allergens: Contains Soy, Milk, may contain traces or Sulphites

Do not exceed the recommended dose, unless advised by your healthcare professional.

Seals/Symbols

Certified B Corporation

Carbon Neutral

GMP Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio.Me IB + by Invivo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio.Me IB + label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio.Me IB + by Invivo

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

IBacillus+ Probiotics

0 NP per serving

E. faecium Rosell-26

0 NP per serving

B. subtilis Rosell-179

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

B. subtilis Rosell-179 monograph & interactions

Other (inactive) ingredients: Potato Starch, Magnesium Stearate, Ascorbic Acid, Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio.Me IB + by Invivo Drug Interactions

Want to check YOUR meds against Bio.Me IB +?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

B. subtilis Rosell-179 182

Individual Drug Interactions

The ingredients in Bio.Me IB + interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Bio.Me IB + interact with drugs. Each result below shows which ingredient is responsible. B. subtilis Rosell-179

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio.Me IB + with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

B. subtilis Rosell-1791 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
B. subtilis Rosell-179 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio.Me IB +, from the product label.

Invivo

See all Invivo products
Name
Invivo Healthcare
State
UK
ZipCode
GL5 2TE
Web Address
invivohealthcare.com
Pharmacist Counseling Corner

Bio.Me IB + by Invivo: Common Questions

Does Bio.Me IB + by Invivo interact with any medications?
Yes. Based on its ingredients, Bio.Me IB + has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio.Me IB + contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does B. subtilis actually work for diarrhea?
B. subtilis Rosell-179 is rated possibly effective for antibiotic-associated diarrhea—the kind that comes on after taking antibiotics. For other types of diarrhea or constipation, the evidence isn't clear enough to say.
What side effects have people reported?
One trial participant reported a headache, and diarrhea has been reported rarely with B. subtilis. The product is generally well tolerated in healthy adults, though safety can vary depending on the specific strain and product quality.
Can I take this while I'm on antibiotics?
Antibiotics can kill the live bacteria in this product, which may reduce its effectiveness. If you're on antibiotics, talk with your doctor or pharmacist about spacing out the timing—don't take them at the same time.
Is it safe to use if I have a weak immune system?
There's a history of rare but serious infections (bacteremia and meningitis) linked to B. subtilis var. natto in people with weakened immunity. Check with your doctor before using this product if you have an immunocompromised condition.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data for these ingredients during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice about whether this product is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bio.Me IB + is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio.Me IB + label
Go deeper

The Full Monographs Behind Bio.Me IB +’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

Bio.Me IB +'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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