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Dietary supplement

Black Cherry 750 mg Ingredients & Drug Interactions

by NaturesPlus Herbal Actives

Black Cherry 750 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Cherry 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Cherry 750 mg is a dietary supplement by NaturesPlus Herbal Actives with 1 active ingredient. Its ingredients are commonly taken for cough, bronchitis and respiratory irritation, sore throat.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Cherry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Black Cherry 750 mg by NaturesPlus Herbal Actives

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Cherry 750 mg by NaturesPlus Herbal Actives — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Black Cherry 750 mg by NaturesPlus Herbal Actives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: black cherry at 750 mg per tablet. Black cherry is a traditional herbal ingredient used in cough and cold products.

The tablet also includes a range of inactive ingredients — hydroxypropyl methylcellulose, stearic acid, beet juice, di-calcium phosphate, microcrystalline cellulose, magnesium stearate, silica, active enzymes, and pharmaceutical glaze — which serve as binders, fillers, and coating.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: nutritional support for free radical defense.
  • We looked for evidence on: antioxidant support, oxidative stress, free radical scavenging, cellular protection.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't hold effectiveness ratings for black cherry in our data, so the strength of evidence for what this product can do is not established here. If you're considering it for a specific purpose, ask your pharmacist what the research actually supports.

The evidence, ingredient by ingredient Wild Cherry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black cherry is generally considered safe in the small amounts found in commercial cough products, but there's a catch: the plant contains compounds that can produce cyanide when broken down in the body. The safety data available advises against using it, particularly in large amounts.

At high doses, cyanide toxicity can occur and may be fatal — a documented case involved a woman who consumed about 300 grams of wild cherries steeped in alcohol and developed severe symptoms including headache, nausea, vomiting, confusion, and difficulty breathing, eventually becoming comatose. During pregnancy, black cherry is rated likely unsafe and should be avoided.

For breastfeeding, there isn't enough safety information available; talk with your doctor or pharmacist before using this product while nursing. Because this supplement is a 750 mg dose in a single tablet, clarify with your pharmacist whether it falls into the "large amount" category of concern.

Side effects, ingredient by ingredient Wild Cherry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Cherry.
  • The most serious interaction on file is rated Moderate.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medications processed by the liver enzyme CYP3A4 — including cholesterol drugs like lovastatin and antifungals like ketoconazole — check them against the interaction tool below before starting this product. The risk is Moderate but so far hasn't been seen in actual patients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Black cherry supplements are a niche choice and come with real safety questions, especially at higher doses and during pregnancy or breastfeeding. If you're interested in it for cough support, the evidence we hold doesn't establish how well it works.

Before you start, check your medications against the interaction tool on this page, and talk with your pharmacist about whether the dose and your personal health situation make this a fit.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Cherry 750 mg, straight from the product label.

Brand NaturesPlus Herbal Actives
Barcode (UPC) 097467073128
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 249506
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Cherry 750 mg by NaturesPlus Herbal Actives, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Extended-Release Tablet(s)
Maximum serving Sizes:
1 Extended-Release Tablet(s)
Servings per container
30
UPC/BARCODE
097467073128
IngredientAmount% DV
Black Cherry750 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Stearic Acid, Beet Juice, Di-Calcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silica, Active-Enzymes, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Nutritional Support for Free Radical Defense. Each Herbal Actives extended-release formula provides rapid and sustained results. Supplying the greatest concentration of active botanical principles, Herbal Actives Black Cherry maximizes the synergistic benefits of the whole berry, which naturally contains anthocyanins, cyanidins and ursolic acid. Guaranteed Maximum Activity: Each Herbal Actives formula is scientifically standardized to the highest level of active principles.

Guaranteed Maximum Activity Extended release Standardized botanical supplement

Gluten Free

Vegetarian

Free from artificial colors and preservatives. Free from all of the major allergens identified in the U.S. Food allergen labeling and consumer protection act.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one tablet daily or as recommended by your health care practitioner.

Precautions

Note: If you are pregnant or nursing, consult your health care professional before using any herbal product.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Herbal Actives is a registered trademark of Natural Organics, Inc. in the US and other countries.

Natural Organics

Formula

0.8% Anthocyanins

Storage

Keep tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Cherry 750 mg by NaturesPlus Herbal Actives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Cherry 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Cherry 750 mg by NaturesPlus Herbal Actives

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Extended-Release Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Black Cherry

Interacts with
643 drugs
750 mg per serving Form: Anthocyanins

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence p...

Black Cherry monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Stearic Acid, Beet Juice, Di-Calcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silica, Active-Enzymes, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Cherry 750 mg by NaturesPlus Herbal Actives Drug Interactions

Want to check YOUR meds against Black Cherry 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Moderate

Ingredients driving the most interactions

Black Cherry 643

Individual Drug Interactions

The ingredients in Black Cherry 750 mg interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Black Cherry 750 mg interact with drugs. Each result below shows which ingredient is responsible. Black Cherry

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Cherry 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Cherry1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes. Theoretically, wild cherry might increase levels of drugs metabolized by CYP3A4. However, so far, this interaction has not been reported in humans.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and others.

Likelihood Possible Evidence D
Black Cherry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Cherry 750 mg, from the product label.

NaturesPlus Herbal Actives

See all NaturesPlus Herbal Actives products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Black Cherry 750 mg by NaturesPlus Herbal Actives: Common Questions

Does Black Cherry 750 mg by NaturesPlus Herbal Actives interact with any medications?
Yes. Based on its ingredients, Black Cherry 750 mg has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Cherry 750 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy?
No. Black cherry is rated likely unsafe in pregnancy and should be avoided. Talk with your doctor or pharmacist about safe alternatives if you need cough or cold support.
Can I take this while breastfeeding?
There isn't enough safety information to know whether black cherry is safe while breastfeeding. For personalized advice on whether to use it, talk with your doctor or pharmacist.
What happens if I take too much?
Large amounts of black cherry can cause cyanide toxicity, which is serious and can be fatal. At 750 mg per tablet, confirm with your pharmacist whether this dose is considered a safe amount or a concerning one for your situation.
Does this actually work for coughs?
We don't hold effectiveness data for black cherry in our system, so I can't tell you from the research we have how well it works. Ask your pharmacist what the scientific evidence actually shows.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Black Cherry 750 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Cherry 750 mg label
Go deeper

The Full Monographs Behind Black Cherry 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Cherry

Interacts with 643 drugs

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence proving it works. The bark, leaves, and s...

Read the full Wild Cherry monograph →
Sources

Sources & How We Checked

Black Cherry 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Cherry 4 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. Pentore, R., Venneri, A., and Nichelli, P. Accidental choke-cherry poisoning: early symptoms and neurological sequelae of an unusual case of cyanide intoxication. Ital.J Neurol.Sci. 1996;17(3):233-235. PubMed

See these in context on the Wild Cherry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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