Blood Sugar Balance Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Blood Sugar Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Blood Sugar Balance is a dietary supplement by Nature's Health with 3 active ingredients. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 980 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema sylvestre, Ceylon Cinnamon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Blood Sugar Balance by Nature's Health
Ask about any prescription or over-the-counter medication and we check it for interactions with Blood Sugar Balance by Nature's Health — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Blood Sugar Balance by Nature's Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Blood Sugar Balance contains 3 active ingredients in a proprietary blend: Gymnema sylvestre, Ceylon cinnamon, and Kousa dogwood. A proprietary blend means the exact amount of each ingredient isn't disclosed separately on the label — you're getting a combined dose.
The capsule itself is made of gelatin.
Does it work?
Not established
The evidence for this product's main claims is limited. For Gymnema sylvestre, we have insufficient reliable evidence to rate it for diabetes, prediabetes (impaired glucose tolerance), or metabolic syndrome.
Ceylon cinnamon fares worse — it's rated possibly ineffective for both diabetes and obesity. We don't have established evidence on file for Kousa dogwood.
Neither ingredient has strong proof that it works for what this product markets.
How safe is it?
Well-documented data
Gymnema is generally well tolerated in the short term, but quality varies between products. It can lower blood sugar, so that's a real concern if you're on diabetes medication.
Rare cases of liver damage (hepatitis) have been reported with heavy daily use of gymnema tea. The safety data advises against gymnema during pregnancy and while breastfeeding because there isn't enough information.
Ceylon cinnamon at food-spice levels is generally safe, but supplement-strength doses are less studied. At food amounts, it's likely fine during pregnancy and breastfeeding, but avoid medicinal or supplement doses without medical advice.
The most common side effects from oral cinnamon are bloating, indigestion, and nausea. Rare cases of bleeding and allergic skin reactions have been reported.
Meds to double-check
Moderate interaction found
Check these medication types before starting: antidiabetes drugs (insulin, metformin, glipizide, and others — risk of low blood sugar), blood pressure medications (antihypertensives), and drugs your liver processes via CYP1A2, CYP2C9, or CYP3A4 enzymes. Use the medication checker on this page to look up your exact prescriptions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is geared toward blood sugar support, but the evidence for either main ingredient is weak or absent. If you take blood pressure or antidiabetes medications, you'll want to check your exact drugs with the tool on this page before starting — the interactions are real.
Talk to your pharmacist or doctor about whether this fits your situation, especially if you're pregnant, breastfeeding, or have liver concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Blood Sugar Balance, straight from the product label.
| Brand | Nature's Health |
|---|---|
| Barcode (UPC) | 698209236735 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 19, 2022 |
| DSLD ID | 263550 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Blood Sugar Balance by Nature's Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 475 mg | -- |
| Gymnema sylvestre | 0 NP | -- |
| Ceylon Cinnamon | 0 NP | -- |
| Kousa Dogwood | 0 NP | -- |
Other ingredients: Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 capsule with meal three times daily.
Formulation
Description: Blood Sugar Balance is formulated to help maintain healthy blood glucose levels and insulin activity. By managing insulin spikes, you'll have more control and sustain over energy levels. This may also help your body maintain its ideal weight.
Helps maintain healthy blood glucose levels and insulin activity Promotes weight loss
Free of wheat, gluten, milk, egg, soybeans, fish, shellfish, peanuts, and tree nuts. Contains no fillers, preservatives, artificial colors, flavors, or sweeteners.
All-natural herbal formula
Precautions
Caution: Do not exceed recommended dose.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
30-day supply 475 mg
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
GMP Good Manufacturing Practice Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Blood Sugar Balance by Nature's Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Blood Sugar Balance by Nature's Health
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Gymnema sylvestre
- › Ceylon Cinnamon
- › Kousa Dogwood
Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
Blood Sugar Balance by Nature's Health Drug Interactions
HelloPharmacist Interaction Report
Blood Sugar Balance by Nature's Health contains two checked ingredients with documented interactions: Gymnema sylvestre and Ceylon cinnamon.
Gymnema carries the most serious concern — it can theoretically increase blood sugar medication risk and may lower your blood sugar too far (low blood sugar/hypoglycemia) when combined with antidiabetes drugs like insulin or metformin. The risk is Moderate.
Read the full breakdown — every affected drug type, severity by severity
Gymnema also affects how your liver processes several types of medications. It can slow the breakdown of drugs metabolized by the CYP1A2 enzyme (including some pain relievers and stimulants), potentially raising their levels.
It may speed up or slow down the clearance of CYP2C9 substrates (a group that includes certain blood thinners and diabetes medications), and it can modestly slow CYP3A4 metabolism — all Moderate or Minor concerns depending on the specific drug.
Ceylon cinnamon adds two more Moderate interactions: it may lower blood pressure additively with blood pressure medications, and it can enhance the blood sugar-lowering effect of antidiabetes drugs. One case report linked cinnamon to bleeding risk, though this is rare.
We could not check Kousa dogwood — we hold no interaction data for it. Altogether, these interactions span 968 individual medications.
Use the medication checker below with your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Blood Sugar Balance?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Blood Sugar Balance interact with 980 drugs. Click any drug to see the details.
2 of the 3 ingredients in Blood Sugar Balance interact with drugs. Each result below shows which ingredient is responsible. Gymnema sylvestre Ceylon Cinnamon
AbrocitinibCibinqo
How Abrocitinib interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Read the full Gymnema Sylvestre + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Blood Sugar Balance — through 2 ingredients. Tap an ingredient for the detail:
Gymnema SylvestreAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Gymnema Sylvestre + Acarbose interactionCeylon CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Ceylon Cinnamon + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Ceylon CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Ceylon Cinnamon + Acebutolol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Blood Sugar Balance — through 1 ingredient. Tap an ingredient for the detail:
Gymnema SylvestreCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Blood Sugar Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Gymnema sylvestre
Antidiabetes Drugs
Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.
Phenacetin
Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.
Tolbutamide (Orinase)
Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.
Ceylon Cinnamon
Antidiabetes Drugs
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Ceylon cinnamon may lower blood glucose levels. Dose adjustments might be necessary.
Antihypertensive Drugs
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.
Brand information
Manufacturer and brand details for Blood Sugar Balance, from the product label.
Nature's Health
See all Nature's Health products- Name
- Nature's Health
- City
- Salt Lake City
- State
- UT
- ZipCode
- 84115
- Phone Number
- (888) 270-0649
- Web Address
- www.natureshealth.com
Blood Sugar Balance by Nature's Health: Common Questions
Does Blood Sugar Balance by Nature's Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this product lower my blood sugar too much if I'm on diabetes medication?
Can I take this if I'm pregnant or breastfeeding?
What does Gymnema sylvestre actually do?
What are the side effects of Ceylon cinnamon?
Is this product effective for weight loss?
What's in the proprietary blend, and why isn't the exact amount listed?
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The Full Monographs Behind Blood Sugar Balance’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gymnema
Interacts with 851 drugsGymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...
Read the full Gymnema monograph → Herb & supplement monographCeylon Cinnamon
Interacts with 258 drugsCeylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited...
Read the full Ceylon Cinnamon monograph →Sources & How We Checked
Blood Sugar Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gymnema 12 references
- Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
- Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
- Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
- Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
- Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
- Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
- Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
- Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
- Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
- Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
- Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
- Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed
Ceylon Cinnamon 22 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70. PubMed
- Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. PubMed
- Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
- Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
- Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
- Oliveira JdA, da Silva IC, Trindade LA, et al. Safety and tolerability of essential oil from Cinnamomum zeylanicum blume leaves with action on oral candidosis and its effect on the physical properties of the acylic resin. Evid Based Complement Alternat Me
- Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275. PubMed
- Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5. PubMed
- Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
- Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
- Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 2017;17(1):550. PubMed
- Zareie A, Sahebkar A, Khorvash F, Bagherniya M, Hasanzadeh A, Askari G. Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial. Phytother Res 2020;34(11):2945-52. PubMed
- Zobeiri M, Parvizi F, Shahpiri Z, et al. Evaluation of the effectiveness of cinnamon oil soft capsule in patients with functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. Evid Based Complement Alternat Med 2021;2021:6634115. PubMed
- Chase C, Doyle A, John SS, Laurent T, Griffith S. Post-operative haemorrhage secondary to cinnamon use. A case report. Int J Surg Case Rep 2022;95:107179. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC