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Dietary supplement

Notoginseng 580 mg Ingredients & Drug Interactions

by Nature's Health

Notoginseng 580 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Notoginseng 580 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Notoginseng 580 mg is a dietary supplement by Nature's Health with 1 active ingredient. Its ingredients are commonly taken for bleeding and bruising, heart and circulation health, high blood pressure.Based on those ingredients, 207 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Panax notoginseng. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Notoginseng 580 mg by Nature's Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Notoginseng 580 mg by Nature's Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Notoginseng 580 mg by Nature's Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Panax notoginseng (580 mg per capsule). Panax notoginseng is an herb traditionally used in Chinese medicine, also called tienchi ginseng.

It's distinct from Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius). There are no other inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote healthy circulation and heart health.
  • We looked for evidence on: Angina, Atherosclerosis, Coronary heart disease (CHD), Hypertension, Myocardial infarction (MI), Stroke — and 3 related terms.
  • The strongest evidence on file: Panax Notoginseng is rated "Possibly Effective" for Angina (Natural Medicines).
  • Also on file: Panax Notoginseng is rated "Possibly Effective" for Stroke.
  • Also on file: Panax Notoginseng is rated "Possibly Ineffective" for Myocardial infarction (MI).

In our data, Panax notoginseng is rated possibly effective for angina (chest pain), stroke, and intracranial hemorrhage (bleeding in the brain). It's rated possibly ineffective for heart attack (myocardial infarction).

For nonalcoholic fatty liver disease (NASH), the evidence is too limited to rate. If you're considering this for any of these conditions, talk with your doctor about what the research actually supports for your specific situation.

The evidence, ingredient by ingredient Panax Notoginseng

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Panax notoginseng appears generally well tolerated in the short term by healthy adults, though human safety data are limited. Taken by mouth, it may cause dry mouth, flushed skin, insomnia, nausea, nervousness, rash, or vomiting.

One case report describes a patient who developed serious bleeding in the throat and esophagus after a single oral dose, though it's unclear whether notoginseng alone was responsible. The safety data advise against use during pregnancy and breastfeeding.

There isn't enough reliable information to know if it's safe while nursing, so talk with your pharmacist or doctor if either applies to you.

Side effects, ingredient by ingredient Panax Notoginseng

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Panax Notoginseng.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 207 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use warfarin (Coumadin) or other blood thinners — notoginseng may increase bleeding risk (Moderate severity). Also ask about aspirin, caffeine-based products, or any medications your liver breaks down using the CYP1A2 enzyme, as notoginseng may affect how they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Notoginseng may be worth considering if you're exploring it for angina, stroke, or related blood-flow conditions — but only under your doctor's guidance. It's not appropriate during pregnancy or while breastfeeding.

Before you start, check your medications with the tool on this page, especially if you take blood thinners or aspirin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Notoginseng 580 mg, straight from the product label.

Brand Nature's Health
Barcode (UPC) 698209801100
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 263619
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Notoginseng 580 mg by Nature's Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
698209801100
IngredientAmount% DV
Panax notoginseng1160 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules twice a day.

Formula

Description: Notoginseng root (Panax notoginseng) may contribute to the maintenance of a healthy heart by helping to maintain a healthy level of blood pressure and circulation. This root may also aid in sustaining healthy blood nourishment as well as help support immune functions.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Promotes healthy circulation Supports heart health

Free of wheat, gluten, milk, egg, soybeans, fish, shellfish, peanuts, and tree nuts. Contains no fillers, preservatives, artificial colors, flavors, or sweeteners.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Notoginseng 580 mg by Nature's Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Notoginseng 580 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Notoginseng 580 mg by Nature's Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Panax notoginseng

Interacts with
207 drugs
1160 mg per serving

Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation. Human evi...

Panax notoginseng monograph & interactions
Interaction report

Notoginseng 580 mg by Nature's Health Drug Interactions

Want to check YOUR meds against Notoginseng 580 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
207Drugs
207 Moderate

Ingredients driving the most interactions

Panax notoginseng 207

Individual Drug Interactions

The ingredients in Notoginseng 580 mg interact with 207 drugs. Click any drug to see the details.

1 of the 1 ingredient in Notoginseng 580 mg interact with drugs. Each result below shows which ingredient is responsible. Panax notoginseng

Each ingredient & the kinds of drugs it affects

For each ingredient in Notoginseng 580 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Panax notoginseng4 drug types · 207 drugs

Aspirin

Theoretically, taking Panax notoginseng concomitantly with aspirin may increase the risk of adverse effects from both products.
Animal research shows that taking Panax notoginseng extract with aspirin increases blood levels of salicylic acid by approximately 50% and blood levels of Panax notoginseng by 75% to 196%. This effect may be due to increased absorption of both products.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking Panax notoginseng may decrease the levels and clinical effects of caffeine.
Animal research shows that administering Panax notoginseng intravenously for 7 days before intraperitoneal injection of caffeine can decrease maximal blood levels of caffeine by 37%. This interaction is attributed to the ability of Panax notoginseng to increase the activity of cytochrome P450 1A2 (CYP1A2) enzymes.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.
Animal research shows that administering Panax notoginseng intravenously for 7 days before intraperitoneal injection of caffeine can decrease maximal blood levels of caffeine by 37%. This interaction was attributed to the ability of Panax notoginseng to increase the activity of CYP1A2.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking Panax notoginseng concomitantly with warfarin may increase the risk of bleeding.
Animal research shows that taking Panax notoginseng concomitantly with warfarin increases plasma warfarin levels, prothrombin time, and international normalized ratio when compared with control. In vitro research also suggests that Panax notoginseng may downregulate expression of cytochrome P450 3A4 enzymes, which may affect warfarin metabolism.

Likelihood Possible Evidence D
Panax notoginseng full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Notoginseng 580 mg, from the product label.

Nature's Health

See all Nature's Health products
Name
Nature's Health
City
Salt Lake City
State
UT
ZipCode
84115
Phone Number
(888) 270-0649
Web Address
www.natureshealth.com
Pharmacist Counseling Corner

Notoginseng 580 mg by Nature's Health: Common Questions

Does Notoginseng 580 mg by Nature's Health interact with any medications?
Yes. Based on its ingredients, Notoginseng 580 mg has a known interaction with 207 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Notoginseng 580 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Panax notoginseng?
It's an herb from traditional Chinese medicine, also called tienchi ginseng. It's different from the more common Asian ginseng and American ginseng you might see on other supplement labels. This product gives you 580 mg per capsule.
Does notoginseng really work for heart and stroke conditions?
Our data show it's possibly effective for angina and stroke, and possibly effective for bleeding in the brain. It's rated possibly ineffective for heart attack. The evidence isn't strong, so talk with your doctor about whether it makes sense for your situation.
Is it safe to take if I'm pregnant or breastfeeding?
No — the safety data advise against it during pregnancy and while breastfeeding. If either applies to you, talk with your pharmacist or doctor before considering this product.
What side effects might I notice?
Most common are dry mouth, nausea, nervousness, insomnia, flushed skin, rash, and vomiting. These are generally mild. One rare case involved serious bleeding in the throat after a single dose, though it's not clear notoginseng alone caused it.
Will this product affect how my blood thinner or aspirin works?
Yes — both are moderate concerns. Notoginseng may raise warfarin levels and bleeding risk, and may boost aspirin levels in your blood. Always check your exact medications with the tool on this page before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Notoginseng 580 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Notoginseng 580 mg label
Go deeper

The Full Monographs Behind Notoginseng 580 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Panax Notoginseng

Interacts with 207 drugs

Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation. Human evidence for these uses is limited and most...

Read the full Panax Notoginseng monograph →
Sources

Sources & How We Checked

Notoginseng 580 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Panax Notoginseng 15 references
  1. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. New York, NY: CRC Press, LLC 1999:101-102.
  2. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Seattle, WA: Eastland Press, 1996:359-60.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Du XF, Yin XP, Zhang GL, Shi HJ, Shao MH. Interstitial granulomatous drug reaction to a Chinese herb extract. Eur J Dermatol. 2012 May-Jun;22(3):419-20. PubMed
  5. Liu R, Qin M, Hang P, Liu Y, Zhang Z, Liu G. Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytother Res. 2012 Aug;26(8):1113-8.
  6. Shang Q, Xu H, Liu Z, Chen K, Liu J. Oral Panax notoginseng Preparation for Coronary Heart Disease: A Systematic Review of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2013;2013:940125.
  7. Tian Z, Pang H, Du S, Lu Y, Zhang L, Wu H, Guo S, Wang M, Zhang Q. Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:136-143. PubMed
  8. Xu D, Huang P, Yu Z, Xing DH, Ouyang S, Xing G. Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action. Front Neurol. 2015 Jan 7;5:274. PubMed
  9. Yang X, Xiong X, Wang J. Sanqi panax notoginseng injection for angina pectoris. Evid Based Complement Alternat Med. 2014;2014:963208. PubMed
  10. Yin Z, Ma L, Xu J, Xia J, Luo D. Pustular drug eruption due to Panax notoginseng saponins. Drug Des Devel Ther. 2014 Jul 16;8:957-61. PubMed
  11. Song H, Wang P, Liu J, Wang C. Panax notoginseng Preparations for Unstable Angina Pectoris: A Systematic Review and Meta-Analysis. Phytother Res. 2017 Jun 20.
  12. Tian Z, Pang H, Zhang Q, et al. Effect of aspirin on the pharmacokinetics and absorption of panax notoginsengsaponins. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 2;1074-75.
  13. Li C, Xu T, Zhou P, et al. Post-marketing safety surveillance and re-evaluation of Xueshuantong injection. BMC Complement Altern Med. 2018;18(1):277. PubMed
  14. Liu L, Shen XJ, Xue LJ, Yao SK, Zhu JY. Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report. World J Clin Cases 2021;9(20):5683-5688. PubMed
  15. Qian J, Chen W, Wu J, et al. Effects and Mechanism of Action of Panax notoginseng Saponins on the Pharmacokinetics of Warfarin. Eur J Drug Metab Pharmacokinet 2022;47(3):331-342. PubMed

See these in context on the Panax Notoginseng monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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