Interactions on record — worth a quick check against your medications. Based on 8 of 14 ingredients. Check your meds →
Dietary supplement

Liver & Kidney Cleanse Ingredients & Drug Interactions

by Nature's Health

Liver & Kidney Cleanse label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liver & Kidney Cleanse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Liver & Kidney Cleanse is a dietary supplement by Nature's Health with 14 active ingredients. Its ingredients are commonly taken for digestive upset and gas, cough and breathing complaints, skin conditions (topical).Based on those ingredients, 1,297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phellodendron, Peony, Poria Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Liver & Kidney Cleanse by Nature's Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Liver & Kidney Cleanse by Nature's Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Liver & Kidney Cleanse by Nature's Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 14 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (540 mg) without saying how much of each component you get.

Liver & Kidney Cleanse contains 14 ingredients, 13 of which are active herbal components in a proprietary blend. The main active ingredients include rehmannia (traditionally used for kidney support), phellodendron (which contains berberine), peony, poria mushroom, chrysanthemum, costus, and several others such as eucommia, Chinese yam, kousa dogwood, Oriental water plantain, mulberry mistletoe, anemarrhena, and amomum (cardamom).

The product contains no inactive other ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: liver and kidney detoxification and purification.
  • We looked for evidence on: Chronic kidney disease (CKD), Cirrhosis, Hepatitis, Nonalcoholic fatty liver disease (NAFLD), Diabetes, Metabolic syndrome — and 4 related terms.
  • The strongest evidence on file: Rehmannia is rated "Possibly Effective" for Chronic kidney disease (CKD) (Natural Medicines).
  • Also on file: Peony is rated "Insufficient Reliable Evidence To Rate" for Cirrhosis, Dyspepsia, Hepatitis.
  • Also on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Diarrhea, Chronic kidney disease (CKD).

The product contains ingredients with limited to insufficient evidence for their intended uses. Rehmannia is rated possibly effective for chronic kidney disease, but other ingredients — including costus, poria mushroom, peony, chrysanthemum, and amomum — carry insufficient evidence ratings for conditions like diabetes, kidney disease, and related disorders.

The evidence base we hold does not establish clear effectiveness for a general 'liver and kidney cleanse' claim.

The evidence, ingredient by ingredient Costus Rehmannia Phellodendron Poria Mushroom Chrysanthemum Peony Black Mulberry Cardamom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several ingredients raise pregnancy and breastfeeding concerns. Costus and rehmannia should be avoided in pregnancy and while breastfeeding due to insufficient safety data; costus is traditionally thought to stimulate the uterus.

Phellodendron (due to berberine content) should be avoided in pregnancy and while breastfeeding — berberine may harm infants. Peony, poria mushroom, and chrysanthemum also lack sufficient safety data for pregnancy and breastfeeding and are best avoided unless approved by your doctor.

Adverse effects are generally rare but can include allergic reactions (costus, chrysanthemum, poria mushroom), gastrointestinal discomfort (peony), and in one case report involving a peony-containing herbal product, bleeding when combined with blood thinners. Amomum (cardamom) at food amounts is generally well tolerated, though concentrated supplement doses have unknown safety.

Side effects, ingredient by ingredient Costus Rehmannia Phellodendron Poria Mushroom Chrysanthemum Peony Black Mulberry Cardamom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Peony, Poria Mushroom, Black Mulberry, Phellodendron, Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,298 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood pressure medications, diabetes drugs, sedatives or sleep aids, blood thinners, birth control pills or hormone therapy, seizure medications (especially phenytoin), the psychiatric medication clozapine, or any drug metabolized by the liver (CYP1A2, CYP2D6, CYP2C9, or CYP3A4). No interactions are documented for the ingredients we could not check in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product brings significant medication interaction risk, especially if you take blood pressure drugs, diabetes medications, sedatives, blood thinners, or drugs metabolized by the liver. Several ingredients also require caution or avoidance during pregnancy and breastfeeding.

Talk with your pharmacist or doctor before starting, and always run your current medications through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liver & Kidney Cleanse, straight from the product label.

Brand Nature's Health
Barcode (UPC) 698209134369
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 263620
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liver & Kidney Cleanse by Nature's Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
698209134369
IngredientAmount% DV
Proprietary Blend540 mg--
Costus0 NP--
Achyranthes0 NP--
Rehmannia0 NP--
Eucommia0 NP--
Chinese Yam0 NP--
Kousa Dogwood0 NP--
Phellodendron0 NP--
Poria Mushroom0 NP--
Chrysanthemum0 NP--
Peony0 NP--
Oriental Water Plantain0 NP--
Mulberry Mistletoe0 NP--
Anemarrhena0 NP--
Amomum0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule three times daily.

Formulation

Description: Liver & Kidney Cleanse may enhance the body's detoxification process and contribute to liver and kidney purification. Optimal liver and kidney function may boost metabolism which may promote favorable regulation of blood sugar and healthy weight management.

All-natural herbal formula Promotes kidney purification Supports healthy liver functions Promotes weight-loss

Free of wheat, gluten, milk, egg, soybeans, fish, shellfish, peanuts, and tree nuts. Contains no fillers, preservatives, artificial colors, flavors, or sweeteners.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statements has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liver & Kidney Cleanse by Nature's Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liver & Kidney Cleanse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liver & Kidney Cleanse by Nature's Health

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

540 mg per serving
Interaction report

Liver & Kidney Cleanse by Nature's Health Drug Interactions

Want to check YOUR meds against Liver & Kidney Cleanse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,297Drugs
1,297 Moderate

Ingredients driving the most interactions

Phellodendron 1,160
Peony 811
Poria Mushroom 417
Rehmannia 258
Mulberry Mistletoe 87

Individual Drug Interactions

The ingredients in Liver & Kidney Cleanse interact with 1,297 drugs. Click any drug to see the details.

5 of the 14 ingredients in Liver & Kidney Cleanse interact with drugs. Each result below shows which ingredient is responsible. Phellodendron Peony Poria Mushroom Rehmannia Mulberry Mistletoe

Each ingredient & the kinds of drugs it affects

For each ingredient in Liver & Kidney Cleanse with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Phellodendron14 drug types · 1,160 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Phellodendron contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, phellodendron might also inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Phellodendron contains berberine. Clinical research shows that berberine may lower blood glucose levels. Theoretically, phellodendron might also lower blood glucose levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Phellodendron contains berberine. Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. Theoretically, phellodendron might also reduce blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Phellodendron contains berberine. Animal research suggests that berberine may have sedative effects. Theoretically, phellodendron might also have CNS depressants effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, phellodendron might increase blood levels of cyclosporine.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can reduce metabolism of cyclosporine and increase serum levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, phellodendron might also reduce the metabolism of cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, phellodendron might also inhibit CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Phellodendron contains berberine. In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, phellodendron might also inhibit CYP2D6.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Phellodendron contains berberine. In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, phellodendron might also inhibit CYP3A4.

Likelihood Possible Evidence D
Dextromethorphan (Robitussin Dm, Others)

Theoretically, phellodendron may increase serum levels of dextromethorphan.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. Theoretically, phellodendron may also inhibit the metabolism of dextromethorphan.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, phellodendron might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Phellodendron contains berberine. Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan. Theoretically, phellodendron might also inhibit the metabolism of losartan.

Likelihood Possible Evidence D
Metformin (Glucophage)

Theoretically, phellodendron might increase the therapeutic and adverse effects of metformin.
Phellodendron contains berberine. In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin. It is unclear if phellodendron might have this same effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, phellodendron might reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam. Theoretically, phellodendron might also inhibit the metabolism of midazolam.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, phellodendron might increase the sedative effect of pentobarbital.
Phellodendron contains berberine. Animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, phellodendron might increase the sedative effects of pentobarbital.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Theoretically, phellodendron might increase blood levels of tacrolimus.
Phellodendron contains berberine. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL. It is unclear if phellodendron might have this same effect.

Likelihood Possible Evidence D
Phellodendron full monograph & interactions

Peony7 drug types · 811 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that peony might have antiplatelet, anticoagulant, and antithrombotic effects.

Likelihood Possible Evidence D
Clozapine (Clozaril)

Theoretically, peony might increase the levels and clinical effects of clozapine.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on cytochromes P450 (CYP) 1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, peony might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro and animal research shows that peony extract has estrogenic activity. Concomitant use might also increase the risk for estrogen-related adverse effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estrogen-related adverse effects.
In vitro and animal research shows that peony extract has estrogenic activity. Theoretically, peony might compete for estrogen receptors and/or cause additive estrogenic effects.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, peony might reduce the levels and clinical effects of phenytoin.
Animal research shows that taking peony root reduces levels of phenytoin. Some researchers suggest that peony root might affect cytochrome P450 (CYP) 2C9, which metabolizes phenytoin. However, preliminary research in humans shows that peony root does not alter levels of losartan (Cozaar), which is also metabolized by CYP2C9.

Likelihood Probable Evidence D
Peony full monograph & interactions

Poria Mushroom3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria Mushroom full monograph & interactions

Rehmannia2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia full monograph & interactions

Mulberry Mistletoe2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
One small clinical study shows that black mulberry leaf extract has hypoglycemic effects. This is supported by in vitro research which also suggests that constituents in black mulberry twigs and leaves might have hypoglycemic effects.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, black mulberry might inhibit the metabolism of midazolam.
In vitro research shows that black mulberry juice can inhibit midazolam 1'-hydroxylation, a reaction that is catalyzed by cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Mulberry Mistletoe full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liver & Kidney Cleanse, from the product label.

Nature's Health

See all Nature's Health products
Name
Nature's Health
City
Salt Lake City
State
UT
ZipCode
84115
Phone Number
(888) 270-0649
Web Address
www.natureshealth.com
Pharmacist Counseling Corner

Liver & Kidney Cleanse by Nature's Health: Common Questions

Does Liver & Kidney Cleanse by Nature's Health interact with any medications?
Yes. Based on its ingredients, Liver & Kidney Cleanse has a known interaction with 1,297 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liver & Kidney Cleanse contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Several ingredients in this product — including costus, rehmannia, phellodendron, peony, poria mushroom, and chrysanthemum — lack sufficient safety data for pregnancy and breastfeeding. Rehmannia and phellodendron should be avoided. Talk with your doctor or pharmacist before use; they can give you personalized advice based on your situation.
What does rehmannia do in this formula?
Rehmannia is traditionally used in Chinese herbal medicine and is rated possibly effective for chronic kidney disease based on the evidence we hold. Other uses listed for it have insufficient evidence. Human safety data are limited, and quality varies between products.
Is phellodendron safe with my other medications?
Phellodendron contains berberine, which can interact with many drug types including blood pressure medications, diabetes drugs, blood thinners, sedatives, and drugs your liver breaks down. Do not start this product without checking your exact medications with the tool on this page and talking to your pharmacist.
Can I use this product for diabetes?
No ingredient in this product has been shown to be effective for diabetes — all are rated insufficient evidence. Two ingredients (rehmannia and phellodendron) may theoretically lower blood sugar, which could be risky if you take diabetes medications. Do not use this for diabetes management without medical supervision.
Are there any common side effects?
Most adverse effects reported are rare or mild. Peony can cause gastrointestinal discomfort like diarrhea, nausea, or abdominal bloating. Allergic reactions (skin rashes, itching, or asthma-like symptoms) have been reported with chrysanthemum and poria mushroom, especially in sensitive people.
What ingredients are in the proprietary blend?
The blend contains costus, achyranthes, rehmannia, eucommia, Chinese yam, kousa dogwood, phellodendron, poria mushroom, chrysanthemum, peony, Oriental water plantain, mulberry mistletoe, anemarrhena, and amomum (cardamom). The exact amounts of each are not disclosed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liver & Kidney Cleanse is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liver & Kidney Cleanse label
Go deeper

The Full Monographs Behind Liver & Kidney Cleanse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Costus

Costus (Saussurea costus) is a root used in Ayurvedic, Unani, and traditional Chinese medicine, mostly for digestive and respiratory complaints. High-quality human evidence is very limited,...

Read the full Costus monograph → Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Phellodendron

Interacts with 1,160 drugs

Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and anti-inflammatory activity in lab studies. Human evi...

Read the full Phellodendron monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Chrysanthemum

Chrysanthemum flowers are most often used as a soothing tea in traditional Chinese medicine and as a folk remedy for eye irritation, colds, and minor inflammation. Solid human evidence for t...

Read the full Chrysanthemum monograph → Herb & supplement monograph

Peony

Interacts with 811 drugs

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formulas. Human evidence for most uses is lim...

Read the full Peony monograph → Herb & supplement monograph

Black Mulberry

Interacts with 87 drugs

Black mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food. Some early research on its leaf and fruit extracts hints at benefits for...

Read the full Black Mulberry monograph → Herb & supplement monograph

Cardamom

Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements...

Read the full Cardamom monograph →
Sources

Sources & How We Checked

Liver & Kidney Cleanse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 81 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Costus 6 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Marzulli, F. N. and Maibach, H. I. Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Contact Dermatitis 1976;2(6):325-329. PubMed
  3. Mitchell, J. C. Contact hypersensitivity to some perfume materials. Contact Dermatitis 1975;1(4):196-199. PubMed
  4. Benezra, C. and Epstein, W. L. Molecular recognition patterns of sesquiterpene lactones in costus-sensitive patients. Contact Dermatitis 1986;15(4):223-230. PubMed
  5. Mitchell, J. C. and Epstein, W. L. Contact hypersensitivity to a perfume material, Costus Absolute. The role of sesquiterpene lactones. Arch.Dermatol 1974;110(6):871-873. DOI
  6. Cheminat, A., Stampf, J. L., Benezra, C., Farrall, M. J., and Frechet, J. M. Allergic contact dermatitis to costus: removal of haptens with polymers. Acta Derm.Venereol. 1981;61(6):525-529. DOI

See these in context on the Costus monograph →

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
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Phellodendron 22 references
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Poria Mushroom 3 references
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Chrysanthemum 25 references
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Peony 15 references
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Black Mulberry 5 references
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Cardamom 2 references
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  2. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agri PubMed

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