Brahmi Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Brahmi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Brahmi is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 930 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Brahmi Whole Herb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Brahmi by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Brahmi by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Brahmi by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: bacopa whole herb extract in dry form. Bacopa is a plant used in traditional medicine for cognitive and mental health purposes.
The liquid also contains alcohol, water, and glycerin as inactive ingredients.
Does it work?
Not established
The evidence for what bacopa actually does isn't established in the data we hold. It's been studied for Alzheimer disease, sexual dysfunction, ADHD, back pain, and cognitive function, but the research doesn't yet support a reliable rating for any of these uses.
If you're considering bacopa for a specific condition, talk with your doctor about whether the evidence supports it for your situation.
How safe is it?
Well-documented data
Bacopa is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are gastrointestinal: abdominal cramps, diarrhea, nausea, dry mouth, headache, bloating, and changes in appetite.
Rates of stomach and bowel side effects have ranged from 12% to 30% in trials. Some people have also reported drowsiness, insomnia, and vivid dreams.
There isn't enough safety information to recommend bacopa during pregnancy or while breastfeeding — the data advises against use in both situations. If you're pregnant, nursing, or planning pregnancy, talk with your doctor or pharmacist before starting.
Meds to double-check
Moderate interaction found
Check the following medication types with your doctor or pharmacist before taking this product: drugs broken down by liver enzymes CYP1A2, CYP2C9, CYP2C19, or CYP3A4 (Moderate); cholinergic drugs that increase acetylcholine (Moderate); anticholinergic drugs that block acetylcholine (Moderate); cevimeline for dry mouth (Moderate); and thyroid hormone (Minor). Use the medication checker on this page to look up your prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Brahmi may be worth considering if you're interested in cognitive support, though evidence for its effectiveness isn't established yet. The main caution is medication interactions — bacopa affects how your liver processes a large number of drugs, and it can interfere with cholinergic and anticholinergic medications.
Before you start, check your exact medications with your doctor or pharmacist using the tool on this page, especially if you take any prescription drugs.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Brahmi, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253608710 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 301301 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Brahmi by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Brahmi Whole Herb Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Formula
Bacopa monnieri
Organic Alcohol Based
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
Made in USA, Hawaii
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Brahmi by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Brahmi by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Brahmi Whole Herb Extract, Dry
Interacts with930 drugs
Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for s...
Brahmi Whole Herb Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Brahmi by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Brahmi by Hawaii Pharm contains bacopa, which interacts with a significant number of medications through effects on how your body processes drugs.
The most serious concern is with drugs broken down by your liver's cytochrome P450 enzymes — specifically CYP1A2, CYP2C9, CYP2C19, and CYP3A4 substrates (Moderate severity). Bacopa may slow how your liver clears these drugs, potentially raising their levels and side effects.
This category includes many common medications, so checking your specific prescriptions is important.
Read the full breakdown — every affected drug type, severity by severity
Bacopa also has Moderate interactions with cholinergic drugs (medications that increase a brain chemical called acetylcholine) because bacopa itself may boost acetylcholine levels, leading to additive effects. It can counteract anticholinergic drugs (medications designed to block acetylcholine), potentially making both less effective.
There's also a case report of someone taking cevimeline (Evoxac, for dry mouth in Sjögren syndrome) who experienced serious symptoms like rapid heart rate and nausea shortly after taking bacopa — this is Moderate severity.
Finally, bacopa has a Minor interaction with thyroid hormone; animal research suggests bacopa may increase thyroid hormone levels, so if you take thyroid replacement, that's worth mentioning to your doctor.
Altogether, these interactions span 931 individual medications. Use the medication checker on this page to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Brahmi?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Brahmi interact with 930 drugs. Click any drug to see the details.
1 of the 1 ingredient in Brahmi interact with drugs. Each result below shows which ingredient is responsible. Brahmi Whole Herb Extract, Dry
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryAnticholinergic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryAnticholinergic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Meperidine interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Orphenadrine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Brahmi — through 1 ingredient. Tap an ingredient for the detail:
Brahmi Whole Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Brahmi Whole Herb Extract, Dry + Acetaminophen, Oxycodone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Brahmi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Brahmi Whole Herb Extract, Dry
Anticholinergic Drugs
Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.
Cevimeline (Evoxac)
Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.
Cholinergic Drugs
Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Thyroid Hormone
Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.
Brand information
Manufacturer and brand details for Brahmi, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
Brahmi by Hawaii Pharm: Common Questions
Does Brahmi by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is bacopa and what's it used for?
Can I take this while pregnant or breastfeeding?
What side effects might I notice?
Does bacopa interact with a lot of medications?
What's in the liquid besides bacopa?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Brahmi’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Brahmi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bacopa 12 references
- Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
- Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
- Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
- Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
- Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
- Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
- Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
- Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
- Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
- Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
- Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC