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Dietary supplement

Calm Drops Lozenges Cherry Flavored Ingredients & Drug Interactions

by Nature's Way

Calm Drops Lozenges Cherry Flavored label
See full label image
Lozenge Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calm Drops Lozenges Cherry Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calm Drops Lozenges Cherry Flavored is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma-Aminobutyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calm Drops Lozenges Cherry Flavored by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Calm Drops Lozenges Cherry Flavored by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calm Drops Lozenges Cherry Flavored by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Calm Drops Lozenges contain one active ingredient: gamma-aminobutyric acid, or GABA, a natural brain chemical involved in relaxation. The lozenges also contain inactive ingredients—cane sugar, brown rice syrup, natural flavors, citric acid, and vegetable and fruit juice—to form and flavor the lozenge.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: fast-acting stress relief and relaxation support.
  • We looked for evidence on: Anxiety, Post-traumatic stress disorder (PTSD), Psychological well-being, Stress management, Mental calmness.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Post-traumatic stress disorder (PTSD), Psychological well-being.

The evidence for GABA supplementation isn't established for the purposes listed on this product. Our data shows insufficient reliable evidence to rate GABA for anxiety, attention deficit-hyperactivity disorder (ADHD), athletic performance, cerebral palsy, or chronic bronchitis.

That doesn't mean it doesn't work—it means the clinical studies we have aren't robust enough to be sure either way.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken orally, GABA is often well tolerated in the short term, though long-term safety hasn't been well studied. The most common side effects reported are drowsiness, nausea, gastric upset, minor throat burning, and muscle weakness.

There's also an old report of one person experiencing a temporary stop in menstruation when taking GABA with phosphatidylserine, though this is very uncommon. Because there isn't enough safety information, it's best to avoid GABA unless your doctor advises otherwise.

The same applies while breastfeeding — there isn't enough data to know whether it's safe.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Calm Drops, double-check your medications if you take blood pressure drugs (Moderate interaction risk) or central nervous system depressants like sleep aids or sedatives (Minor risk). Use the medication search tool below to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Calm Drops might appeal to someone looking for a natural relaxation aid, but the evidence for its effectiveness isn't solid. If you take blood pressure medication or anything that makes you drowsy, check your exact medications with the tool on this page before starting.

Talk with your pharmacist about whether this product is right for you, especially if you're pregnant, breastfeeding, or taking other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calm Drops Lozenges Cherry Flavored, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674149836
Net contents 24 Lozenge(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 334422
Product type Non-nutrient/non-botanical
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calm Drops Lozenges Cherry Flavored by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
24
UPC/BARCODE
033674149836
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Gamma-Aminobutyric Acid100 mg--

Other ingredients: Cane Sugar, Brown Rice syrup, Natural Flavors, Citric Acid, Vegetable and Fruit Juice

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Soothe stress within 60 minutes Works quickly to help ease stress Fast-acting support lozenges

Gluten free. No salt, wheat, soy, egg, peanut, dairy, or gelatin.

Packaged and tested in the USA

Vegan Gelatin Free

Vegan Gelatin Free

Fast-acting support to help calm the mind in response to stress Drug-free, non-habit forming lozenges

Drug-free, non-habit forming lozenges

Formula

Calm Drops Lozenges with fast-acting GABA Fast-acting GABA works within 60 minutes to promote a relaxed mental state

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 lozenge daily as needed. Allow lozenge to dissolve slowly in mouth; do not chew.

Precautions

Not formulated for children. Keep out of reach of children.

Warning: Do not take if you are pregnant or nursing. If you have high blood pressure or if you are taking any medications, consult a healthcare professional before use.

Do not exceed recommended dose. Do not use if package is open or torn, or if individual pieces are unwrapped.

Storage

Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Copyright 2024

Seals/Symbols

Vegan Gelatin Free

General Statements

Individually wrapped lozenges are designed for on-the-go use Explore more products at NATURESWAY.COM

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calm Drops Lozenges Cherry Flavored by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calm Drops Lozenges Cherry Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calm Drops Lozenges Cherry Flavored by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container24 Amounts shown are per serving.

Gamma-Aminobutyric Acid

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma-Aminobutyric Acid monograph & interactions

Other (inactive) ingredients: Cane Sugar, Brown Rice syrup, Natural Flavors, Citric Acid, Vegetable and Fruit Juice. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calm Drops Lozenges Cherry Flavored by Nature's Way Drug Interactions

Want to check YOUR meds against Calm Drops Lozenges Cherry Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma-Aminobutyric Acid 419

Individual Drug Interactions

The ingredients in Calm Drops Lozenges Cherry Flavored interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calm Drops Lozenges Cherry Flavored interact with drugs. Each result below shows which ingredient is responsible. Gamma-Aminobutyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Calm Drops Lozenges Cherry Flavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma-Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma-Aminobutyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calm Drops Lozenges Cherry Flavored, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Calm Drops Lozenges Cherry Flavored by Nature's Way: Common Questions

Does Calm Drops Lozenges Cherry Flavored by Nature's Way interact with any medications?
Yes. Based on its ingredients, Calm Drops Lozenges Cherry Flavored has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calm Drops Lozenges Cherry Flavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is GABA and what's it supposed to do?
GABA is gamma-aminobutyric acid, a natural chemical your brain makes that promotes relaxation. In this lozenge form, it's meant to help with calm and relaxation, though the evidence for how well it works isn't yet established in our data.
Will this make me drowsy?
Some people report drowsiness as a side effect when taking GABA orally. The lozenge form specifically hasn't had adverse effects reported in studies, but drowsiness is still a possibility. If you're sensitive to sedating effects, start cautiously.
Is this safe to take long-term?
GABA lozenges are generally well tolerated short-term, but long-term safety hasn't been well studied. If you're thinking of taking this regularly, talk with your pharmacist or doctor first.
Can I take this while pregnant?
There isn't enough safety information to know whether GABA is safe during pregnancy. Talk with your doctor or pharmacist before using this product if you're pregnant or planning to become pregnant.
Is it safe while breastfeeding?
No — there isn't enough safety information, so it's best to avoid GABA while breastfeeding. If you're nursing and interested in a calming support, ask your pharmacist or doctor what alternatives might be safer for you.
Are there any fillers or other stuff in here?
Yes, the inactive ingredients are cane sugar, brown rice syrup, natural flavors, citric acid, and vegetable and fruit juice — those give the lozenge its form and taste.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calm Drops Lozenges Cherry Flavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calm Drops Lozenges Cherry Flavored label
Go deeper

The Full Monographs Behind Calm Drops Lozenges Cherry Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

Calm Drops Lozenges Cherry Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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