Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Cardio Peak Ingredients & Drug Interactions

by Life Extension

Cardio Peak label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cardio Peak against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cardio Peak is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for heart health and circulation, digestive problems (constipation, diarrhea), cholesterol support.Based on those ingredients, 933 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rejuna. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cardio Peak by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Cardio Peak by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cardio Peak by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Cardio Peak contains two active ingredients: Rejuna (a form of Terminalia, a tree extract traditionally used in Ayurvedic medicine) and Oligomeric Proanthocyanidins (a type of plant compound found in grape seeds and other sources). The product is rounded out with inactive ingredients — cellulose, maltodextrin, microcrystalline cellulose, stearate, and silica — which are fillers and binders that help form the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Terminalia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart health and circulation support.
  • We looked for evidence on: Angina, Coronary heart disease (CHD), Heart failure, Hyperlipidemia, Hypertension, Cardiovascular health — and 1 related terms.
  • The closest evidence on file: Terminalia is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Terminalia is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Heart failure, Hyperlipidemia, Hypertension.

The evidence for Rejuna's effectiveness in Cardio Peak isn't yet established. Our data shows insufficient reliable evidence to rate how well it works for obesity, high cholesterol (hyperlipidemia), high blood pressure (hypertension), or angina.

No effectiveness ratings are on file for the Oligomeric Proanthocyanidins in this product either.

The evidence, ingredient by ingredient Terminalia

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rejuna is generally well tolerated in short-term studies, though long-term safety data and product quality vary depending on the brand and batch. The safety information isn't robust enough to recommend this ingredient during pregnancy or while breastfeeding — the data advises against both.

No adverse effects from clinical trials are recorded in our data.

Side effects, ingredient by ingredient Terminalia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Terminalia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 934 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Cardio Peak, double-check with your pharmacist if you're on any CYP2D6, CYP2C9, or CYP3A4 substrate medications (Rejuna slows how your body clears these), blood thinners or antiplatelet drugs, diabetes medications, chlorzoxazone (a muscle relaxant), or omeprazole (heartburn medication). All of these interactions are rated Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Cardio Peak may interest someone looking to support heart health, but it's not a simple add-on if you take prescription medications. The Rejuna ingredient can slow how your liver clears a large number of drugs, which may raise their levels and side effects.

Talk with your pharmacist before starting, especially if you take blood thinners, diabetes drugs, muscle relaxants, or heartburn medication — and avoid it in pregnancy and while nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cardio Peak, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870170099
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 328307
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cardio Peak by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
737870170099
IngredientAmount% DV
Rejuna750 mg--
Oligomeric Proanthocyanidins30 mg--

Other ingredients: Cellulose, Maltodextrin, Microcrystalline Cellulose, Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take two (2) capsules twice daily, or as recommended by a healthcare practitioner.

Precautions

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Brand IP Statement(s)

Rejuna is a trademark of Verdure Sciences, Inc.

Formulation

Gluten Free Non GMO LE Certified

Cellular support for heart muscle

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cardio Peak by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cardio Peak label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cardio Peak by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rejuna

Interacts with
933 drugs
750 mg per serving Form: Arjuna Bark Extract

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes....

Rejuna monograph & interactions

Oligomeric Proanthocyanidins

30 mg per serving Form: Hawthorn Fruit, Flower, Stem Extract

Other (inactive) ingredients: Cellulose, Maltodextrin, Microcrystalline Cellulose, Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cardio Peak by Life Extension Drug Interactions

Want to check YOUR meds against Cardio Peak?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
933Drugs
933 Moderate

Ingredients driving the most interactions

Rejuna 933

Individual Drug Interactions

The ingredients in Cardio Peak interact with 933 drugs. Click any drug to see the details.

1 of the 2 ingredients in Cardio Peak interact with drugs. Each result below shows which ingredient is responsible. Rejuna

Each ingredient & the kinds of drugs it affects

For each ingredient in Cardio Peak with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rejuna7 drug types · 933 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.

Likelihood Possible Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.

Likelihood Possible Evidence D
Omeprazole (Prilosec)

Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.

Likelihood Possible Evidence D
Rejuna full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cardio Peak, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Cardio Peak by Life Extension: Common Questions

Does Cardio Peak by Life Extension interact with any medications?
Yes. Based on its ingredients, Cardio Peak has a known interaction with 933 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cardio Peak contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cardio Peak while I'm pregnant?
No. The safety data isn't sufficient, and the ingredient information advises against use during pregnancy. Talk with your doctor or pharmacist for personalized guidance.
Is it okay to take this while breastfeeding?
No. There isn't enough safety information, and the data advises against use while breastfeeding. Check with your doctor or pharmacist for what's safe for you.
Does Cardio Peak actually work for high cholesterol or high blood pressure?
The evidence isn't established yet. Our data shows insufficient reliable evidence to rate how well Rejuna works for those conditions.
What does Rejuna do?
Rejuna is an extract from Terminalia, a tree used traditionally in Ayurvedic medicine. It's included in Cardio Peak for cardiovascular support, though robust evidence for its benefits isn't yet on file.
Will this product interact with my other medications?
Possibly. Rejuna can slow how your liver clears many drugs, and it also affects blood thinners and diabetes medications. Use the medication checker on this page with your exact prescriptions to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cardio Peak is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cardio Peak label
Go deeper

The Full Monographs Behind Cardio Peak’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Terminalia

Interacts with 933 drugs

Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...

Read the full Terminalia monograph →
Sources

Sources & How We Checked

Cardio Peak's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Terminalia 9 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
  3. Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
  4. Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
  5. Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
  6. Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
  7. Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
  8. Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
  9. Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed

See these in context on the Terminalia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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