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Dietary supplement

Chaparral Larrea tridentata Ingredients & Drug Interactions

by Earth Friend Herb Co.

Chaparral Larrea tridentata label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chaparral Larrea tridentata against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chaparral Larrea tridentata is a dietary supplement by Earth Friend Herb Co. with 1 active ingredient. Its ingredients are commonly taken for pain and inflammation, skin conditions, antioxidant/general wellness.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaparral. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chaparral Larrea tridentata by Earth Friend Herb Co.

Ask about any prescription or over-the-counter medication and we check it for interactions with Chaparral Larrea tridentata by Earth Friend Herb Co. — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chaparral Larrea tridentata by Earth Friend Herb Co.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: chaparral (Larrea tridentata). The liquid is prepared in a base of alcohol, distilled water, and glycerin.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Chaparral product and its label doesn't state a use — see Chaparral's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts provided do not include effectiveness data for chaparral, so we can't tell you whether it works for any particular use.

The evidence, ingredient by ingredient Chaparral

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chaparral is not recommended. The safety data links it to serious liver and kidney toxicity, and the adverse effects are severe — hepatotoxicity can cause jaundice, fatigue, right upper quadrant belly pain, dark urine, light stools, nausea, diarrhea, weight loss, fever, and loss of appetite.

It can also lead to cirrhosis, inflammation of the bile ducts, acute liver inflammation, and liver failure, with documented cases requiring liver transplant. Topically, it can cause contact dermatitis.

Avoid this product during pregnancy and while breastfeeding due to toxicity concerns and lack of safety data. The safety data advises against use in both situations.

Side effects, ingredient by ingredient Chaparral

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chaparral.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you're on any drugs that stress the liver (hepatotoxic medications) — there is a Moderate-severity risk of additive liver damage. Use the medication checker on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

The safety profile here is serious — chaparral carries a well-documented risk of liver and kidney damage that may outweigh any benefit. If you're considering this product, talk with your pharmacist or doctor first, especially if you take any medications that affect your liver or have liver or kidney concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chaparral Larrea tridentata, straight from the product label.

Brand Earth Friend Herb Co.
Net contents 1 Fluid Ounce; 30 Milliliter(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 323588
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chaparral Larrea tridentata by Earth Friend Herb Co., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
10 Drop(s)
Servings per container
30
IngredientAmount% DV
Chaparral0 NP--

Other ingredients: Alcohol, Water, Distilled, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Use 10 drops 3x daily. Take straight-then drink water.

Precautions

Keep away from children.

Not for use with pregnancy or nursing.

General Statements

An Elijah Free formula

Formulation

All certified organic or wild crafted herbs.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chaparral Larrea tridentata by Earth Friend Herb Co. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chaparral Larrea tridentata label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chaparral Larrea tridentata by Earth Friend Herb Co.

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Chaparral

Interacts with
370 drugs
0 NP per serving

Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious a...

Chaparral monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Distilled, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chaparral Larrea tridentata by Earth Friend Herb Co. Drug Interactions

Want to check YOUR meds against Chaparral Larrea tridentata?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

Chaparral 370

Individual Drug Interactions

The ingredients in Chaparral Larrea tridentata interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in Chaparral Larrea tridentata interact with drugs. Each result below shows which ingredient is responsible. Chaparral

Each ingredient & the kinds of drugs it affects

For each ingredient in Chaparral Larrea tridentata with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chaparral1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Likelihood Possible Evidence D
Chaparral full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chaparral Larrea tridentata, from the product label.

Earth Friend Herb Co.

See all Earth Friend Herb Co. products
Name
Exsula Foods Inc.
Street Address
PO Box 44459
City
Tacoma
State
WA
ZipCode
98448
Phone Number
253-874-9092
Web Address
www.exsula.com
Pharmacist Counseling Corner

Chaparral Larrea tridentata by Earth Friend Herb Co.: Common Questions

Does Chaparral Larrea tridentata by Earth Friend Herb Co. interact with any medications?
Yes. Based on its ingredients, Chaparral Larrea tridentata has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chaparral Larrea tridentata contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and while breastfeeding due to toxicity concerns and lack of safety data. Talk with your doctor or pharmacist for guidance.
What are the main side effects I should watch for?
Chaparral can cause liver damage (hepatotoxicity) with symptoms like jaundice, fatigue, belly pain on the right side, dark urine, light stools, nausea, diarrhea, weight loss, fever, and loss of appetite. Severe cases have led to cirrhosis and liver failure requiring transplant. Applied to skin, it can cause a rash (contact dermatitis).
Why does the product facts say 'avoid' for chaparral?
Chaparral has been linked to serious liver and kidney toxicity. The documented risks are significant enough that health data advises against use — the potential harms may outweigh any benefits.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chaparral Larrea tridentata is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chaparral Larrea tridentata label
Go deeper

The Full Monographs Behind Chaparral Larrea tridentata’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chaparral

Interacts with 370 drugs

Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious and sometimes irreversible liver and kidn...

Read the full Chaparral monograph →
Sources

Sources & How We Checked

Chaparral Larrea tridentata's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chaparral 16 references
  1. Smith BC, Desmond PV. Acute hepatitis induced by ingestion of the herbal medication chaparral. Aust N Z J Med 1993;23:526.. PubMed
  2. Gordon DW, Rosenthal G, Hart J, et al. Chaparral ingestion: the broadening spectrum of liver injury caused by herbal medications. JAMA 1995;273:489-90.
  3. Batchelor WB, Heathcote J, Wanless IR. Chaparral-induced hepatic injury. Am J Gastroenterol 1995;90:831-3.
  4. Katz M, Saibil F. Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6.
  5. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  6. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med 1997;157:913-9. DOI
  7. Heron S, Yarnell E. The safety of low-dose Larrea tridentata (DC) Coville (creosote bush or chaparral): a retrospective clinical study. J Altern Complement Med 2001;7:175-85..
  8. Chaparral-induced toxic hepatitis-California and Texas, 1992. MMWR Morb Mortal Wkly Rep 1992;41:812-4.. DOI
  9. Estes JD, Stolpman D, Olyaei A, et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg 2003;138:852-8.. PubMed
  10. Lambert JD, Zhao D, Meyers RO, et al. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 2002;40:1701-8.. PubMed
  11. Shasky DR. Contact dermatitis from Larrea tridentata (creosote bush). J Am Acad Dermatol 1986;15:302.. PubMed
  12. Smith AY, Feddersen RM, Gardner KD Jr, Davis CJ Jr. Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: a case report. J Urol 1994;152:2089-91.. PubMed
  13. Kauma, H., Koskela, R., Makisalo, H., Autio-Harmainen, H., Lehtola, J., and Hockerstedt, K. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand.J Gastroenterol. 2004;39(11):1168-1171. PubMed
  14. Leonforte, J. F. Contact dermatitis from Larrea (creosote bush). J Am Acad.Dermatol. 1986;14(2 Pt 1):202-207. PubMed
  15. Alderman, S., Kailas, S., Goldfarb, S., Singaram, C., and Malone, D. G. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin.Gastroenterol. 1994;19(3):242-247.
  16. Clark, F. Chaparral-induced toxic hepatitis: California and Texas, 1992. MMWR Morb Mortal Wkly Rep. 1992;41:812-814. DOI

See these in context on the Chaparral monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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