Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Chewable Papaya Enzyme With Chlorophyll Ingredients & Drug Interactions

by American Health

Chewable Papaya Enzyme With Chlorophyll label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable Papaya Enzyme With Chlorophyll against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable Papaya Enzyme With Chlorophyll is a dietary supplement by American Health with 6 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 417 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyll, Papaya, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chewable Papaya Enzyme With Chlorophyll by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Papaya Enzyme With Chlorophyll by American Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chewable Papaya Enzyme With Chlorophyll by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 5 active ingredients: protease (a digestive enzyme), papaya fruit extract, papain (an enzyme from papaya), alpha-amylase (another digestive enzyme), and chlorophyll. Together they're designed to support digestion — the enzymes break down proteins and starches, while papaya and chlorophyll are traditional digestive aids.

The product also contains several inactive ingredients: sucrose, calcium carbonate, stearic acid, corn starch, vegetable magnesium stearate, papaya flavor, date powder, and fructose.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive health and breath freshness.
  • We looked for evidence on: Constipation, Halitosis, Intestinal parasite infection, Indigestion, Bloating, Nutrient absorption.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection.
  • Also on file: Chlorophyll is rated "Insufficient Reliable Evidence To Rate" for Constipation, Halitosis.

The evidence we hold rates the effectiveness of papaya and papain for several uses — including cancer, diabetes, exercise muscle soreness, and wound healing — as insufficient. That means either the research is limited or conflicting, so we can't reliably say whether these ingredients work for those purposes.

The data we have doesn't establish effectiveness for the digestive enzyme or chlorophyll components either.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Papaya Papain Chlorophyll

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated but may cause digestive upset or allergic reactions in some people. Papaya fruit in food amounts is generally safe, but concentrated supplements and unripe papaya are less well studied — most common side effects are nausea and vomiting.

Papain can cause allergic reactions, including itchy eyes, runny nose, sneezing, abdominal cramps, and diarrhea in sensitive individuals; high doses may cause serious digestive problems. Chlorophyll is generally well tolerated in short-term use, but the most common side effect is photosensitization — it can make your skin more sensitive to sunlight, and in rare cases has caused a condition called pseudoporphyria with blistering on the hands.

During pregnancy, safety data advise against using protease unless prescribed, papain and concentrated papaya products, and chlorophyll — unripe papaya and papaya seeds should also be avoided. Papaya fruit itself is likely safe during pregnancy.

During breastfeeding, there isn't enough reliable data for protease, papain, or chlorophyll, so talk with your doctor or pharmacist before using this product if you're nursing.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Papaya Papain Chlorophyll

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Papain, Papaya, Chlorophyll.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 417 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take any blood thinners (especially warfarin), diabetes medications, levothyroxine (thyroid hormone), amiodarone (heart medication), photosensitizing drugs, or methotrexate — these are the medication types with documented interactions. All are Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take warfarin, diabetes drugs, thyroid medication, heart rhythm medication, photosensitizing drugs, or methotrexate, check with us or your pharmacist before starting this. Digestive enzyme products like this one are generally used short-term; if you're pregnant or breastfeeding, talk to your doctor first.

The digestive support claims here aren't well established in the research we hold.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable Papaya Enzyme With Chlorophyll, straight from the product label.

Brand American Health
Barcode (UPC) 076630503037
Net contents 100 Chewable Tablet(s)
Market status On market
Date entered into DSLD May 22, 2016
DSLD ID 60126
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable Papaya Enzyme With Chlorophyll by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
33
UPC/BARCODE
076630503037
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Sugar1 Gram(s)--
Protease6 mg--
Papaya3 mg--
Papain45 mg--
Alpha-Amylase6 mg--
Chlorophyll3 mg--

Other ingredients: Sucrose, Calcium Carbonate, Stearic Acid, Corn Starch, Vegetable Magnesium Stearate, Papaya flavor, Date powder, Fructose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Our famous blend with Chlorophyll is the perfect “after meal” supplement to help support and maintain daily digestive health.*

Take this delicious natural papaya enzyme regularly to promote gastrointestinal wellness while helping to reduce bad taste and sweeten breath.*

NATURAL DIGESTIVE ENZYME SUPPORT* PROMOTES NUTRIENT ABSORPTION*

Digestive Health

Formula

We combine the finest quality of freshly ripened Papaya fruit with papain, amylase and protease enzymes to aid in the digestion of proteins and carbohydrates, while encouraging proper nutrient absorption.*

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

the "after meal" supplement

Formulation

VEGETARIAN FORMULA

No Gluten, No Yeast, No Wheat, No Milk or Milk Derivatives, No Lactose, No Soy, No Egg, No Grapefruit, No Preservatives, No Artificial Color, No Sodium.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, chew three (3) tablets following a meal, one to three times daily, or dissolve one (1) or two (2) tablets in mouth when needed.

General

PROD. NO. 80990 B991 11C

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable Papaya Enzyme With Chlorophyll by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable Papaya Enzyme With Chlorophyll label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable Papaya Enzyme With Chlorophyll by American Health

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container33 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Protease

No known
interactions
6 mg per serving Form: Aspergillus oryzae

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Papaya

Interacts with
92 drugs
3 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya monograph & interactions

Papain

Interacts with
2 drugs
45 mg per serving Form: Carica papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Alpha-Amylase

6 mg per serving Form: Aspergillus oryzae

Chlorophyll

Interacts with
337 drugs
3 mg per serving Form: Alfalfa

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reduc...

Chlorophyll monograph & interactions

Other (inactive) ingredients: Sucrose, Calcium Carbonate, Stearic Acid, Corn Starch, Vegetable Magnesium Stearate, Papaya flavor, Date powder, Fructose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable Papaya Enzyme With Chlorophyll by American Health Drug Interactions

Want to check YOUR meds against Chewable Papaya Enzyme With Chlorophyll?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
417Drugs
417 Moderate

Ingredients driving the most interactions

Chlorophyll 337
Papaya 92
Papain 2

Individual Drug Interactions

The ingredients in Chewable Papaya Enzyme With Chlorophyll interact with 417 drugs. Click any drug to see the details.

3 of the 6 ingredients in Chewable Papaya Enzyme With Chlorophyll interact with drugs. Each result below shows which ingredient is responsible. Chlorophyll Papaya Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable Papaya Enzyme With Chlorophyll with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorophyll2 drug types · 337 drugs

Methotrexate (Trexall, Others)

Theoretically, chlorophyll may reduce the clearance of methotrexate.
In one case report, a 54-year-old male developed delayed clearance of intravenous high-dose methotrexate with concomitant use of chlorophyll. When chlorophyll was stopped 2 days prior to methotrexate treatment, methotrexate clearance was unaffected.

Likelihood Possible Evidence B
Photosensitizing Drugs

Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Chlorophyll has been reported to cause photosensitization. In two case reports, pseudoporphyria developed after oral intake of chlorophyll. Theoretically, concomitant use with other photosensitizing drugs may exacerbate this effect.

Likelihood Probable Evidence B
Chlorophyll full monograph & interactions

Papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable Papaya Enzyme With Chlorophyll, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Web Address
www.AmericanHealthUS.com
Pharmacist Counseling Corner

Chewable Papaya Enzyme With Chlorophyll by American Health: Common Questions

Does Chewable Papaya Enzyme With Chlorophyll by American Health interact with any medications?
Yes. Based on its ingredients, Chewable Papaya Enzyme With Chlorophyll has a known interaction with 417 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable Papaya Enzyme With Chlorophyll contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion?
The product contains digestive enzymes and papaya, which are traditional digestive aids, but the evidence we hold doesn't clearly establish whether they work for that purpose. If you have ongoing digestive problems, talk with your pharmacist or doctor about what might help.
Can I take this if I'm pregnant?
Not without talking to your doctor first. Safety data advise against protease, papain, and chlorophyll during pregnancy, and you should avoid unripe papaya and papaya seeds. Ripe papaya fruit itself is likely safe, but this is a concentrated supplement, not just food.
What are the most common side effects?
Nausea and vomiting are possible from the papaya and papain. Digestive upset can happen with protease. Chlorophyll can make your skin more light-sensitive, especially in the sun.
Is this safe if I'm breastfeeding?
There isn't enough reliable safety data for protease, papain, or chlorophyll during breastfeeding. Talk with your doctor or pharmacist before using this product while nursing.
What is papain, and why is it in here?
Papain is an enzyme from papaya fruit that breaks down proteins, which is why it's included in a digestive enzyme product. But it can cause allergic reactions in sensitive people and may interact with blood thinners like warfarin.
What does chlorophyll do in this product?
Chlorophyll is a traditional digestive aid added to the formula, but evidence for its effectiveness isn't well established in our data. One thing to know: it can make your skin more sensitive to sun, and it may slow how your body clears methotrexate if you take that medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable Papaya Enzyme With Chlorophyll label
Go deeper

The Full Monographs Behind Chewable Papaya Enzyme With Chlorophyll’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Chlorophyll

Interacts with 337 drugs

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...

Read the full Chlorophyll monograph →
Sources

Sources & How We Checked

Chewable Papaya Enzyme With Chlorophyll's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Chlorophyll 5 references
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  3. Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

See these in context on the Chlorophyll monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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