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Dietary supplement

Children's Ultra Clear Propolis Liquid Ingredients & Drug Interactions

by CATALO

Children's Ultra Clear Propolis Liquid label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Children's Ultra Clear Propolis Liquid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Children's Ultra Clear Propolis Liquid is a dietary supplement by CATALO with 1 active ingredient. Its ingredients are commonly taken for cold sores and herpes lesions (topical), sore throat and mouth sores, wound and skin healing.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Propolis Extract, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Children's Ultra Clear Propolis Liquid by CATALO

Ask about any prescription or over-the-counter medication and we check it for interactions with Children's Ultra Clear Propolis Liquid by CATALO — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Children's Ultra Clear Propolis Liquid by CATALO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: propolis extract, derived naturally. Propolis is a resinous substance collected by honeybees.

The inactive ingredients — glycerol, purified water, anethole, and peppermint oil — are excipients that carry and flavor the liquid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune support and throat respiratory health.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Common cold, Oral mucositis, Canker sores, Gingivitis, Periodontitis — and 4 related terms.
  • The strongest evidence on file: Propolis is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).
  • Also on file: Propolis is rated "Possibly Effective" for Oral mucositis.
  • Also on file: Propolis is rated "Insufficient Reliable Evidence To Rate" for Common cold, Gingivitis, Upper respiratory tract infection (URTI), Periodontitis, and more.

In the data we hold, propolis is rated possibly effective for oral mucositis (mouth sores from cancer treatment or other causes) and herpes labialis (cold sores). For diabetes, the evidence supports a possibly effective rating as well.

The evidence for dengue fever is insufficient to rate it. If you're considering this product for your child, talk with your pediatrician about whether propolis is appropriate for their specific condition.

The evidence, ingredient by ingredient Propolis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Propolis is generally well tolerated short term, though allergic reactions are possible — especially in children sensitive to bee products. The most common side effect reported orally is headache; in one trial, around 7% of people taking propolis reported mild headache.

Topically (if applied to skin), it can cause contact dermatitis or allergic reactions in sensitive individuals. Children with a bee allergy should avoid propolis products entirely.

There isn't enough reliable safety information to recommend propolis during pregnancy or breastfeeding, so it should be avoided in those situations. If your child has any history of bee allergies or severe allergic reactions, talk with your pediatrician before starting.

Side effects, ingredient by ingredient Propolis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Propolis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before giving this to your child if they take blood thinners or antiplatelet drugs (Moderate severity) — propolis may increase bleeding risk. Also ask about warfarin specifically (Moderate severity), as propolis may reduce how well it works.

Additionally, propolis may affect blood levels of many other medications processed by the liver, so run any prescription drug through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a single-ingredient liquid propolis extract. It's possibly effective for mouth sores and cold sores, and it's generally well tolerated — but allergic reactions and headache do occur.

Before giving it to your child alongside any prescription medication, especially blood thinners or heart drugs, check with your pharmacist. If your child is allergic to bees or bee products, skip this one.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Children's Ultra Clear Propolis Liquid, straight from the product label.

Brand CATALO
Net contents 60 Milliliter(s); 2 Bottle(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303041
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Children's Ultra Clear Propolis Liquid by CATALO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 mL
Maximum serving Sizes:
0.75 mL
Servings per container
120
IngredientAmount% DV
Propolis Extract, Natural250 mg--

Other ingredients: Glycerol, Water, Purified, Anethole, Peppermint Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Catalo Children's Ultra Clear Propolis Liquid is a gentle and multi-purpose liquid form of premium grade Propolis in Australia, containing rich bioflavonoids content. Its strong immune and antibacterial properties are specially designed for children with throat or respiratory tract discomfort and symptoms of cold or flu.

Suggested/Recommended/Usage/Directions

It is also an easy way to care for mouth ulcers, swelling gum and skin irritations by external application.

Serving directions For age 2-5, take 5 drops (0.25 mL) 2 times daily. For age 6-12, take 6-10 drops (0.3 mL-0.5 mL) 2 times daily. For age 13 or above, take 11-15 drops (0.55 mL-0.75 mL) 2 times daily. Take directly or add into water, juice or food. Stir well and serve. External use: Suitable for minor wound and skin irritations, swab affected area 2-4 times daily

Formulation

By using advanced technology, Catalo Children's Ultra Clear Propolis Liquid Extract is alcohol-free and water-soluble, containing no artificial flavors, colors and preservatives, which make it gentle for kid's stomach and high bioavailability.

It is made naturally sweet from plant fennel oil to give a refreshing aroma and taste that children love!

Main functions: Relief from symptoms of throat and respiratory discomfort Alleviate mouth ulcers and swelling gum Strengthen natural immune function Improve healing of minor wounds

Suitable for: Children, teenagers with throat discomfort, mouth ulcers, bad breath and skin irritation, enhance immunity and respiratory tract health, do not like the bitter and spicy taste of propolis

Water soluble 100% alcohol free Naturally sweet No bitter taste

Water soluble 100% alcohol free

Made in Australia

The product may contain black precipitates. This is a normal phenomenon and does not affect product quality.

Storage

Storage Keep in a dry and cool place. Avoid direct sunlight

Precautions

Not suitable for children under two years old.

Propolis may cause skin irritation or allergic reactions. Test before use. If irritation or swelling of the mouth or throat occur, discontinue use.

Advise to take with adult supervision.

General Statements

Scan and discover more about me!

Net weight 60 mL (2 bottles x 30 mL)

Seals/Symbols

cGMP Current Good Manufacturing Practices Quality Efficacy Natural Potency Safety

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Children's Ultra Clear Propolis Liquid by CATALO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Children's Ultra Clear Propolis Liquid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Children's Ultra Clear Propolis Liquid by CATALO

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Propolis Extract, Natural

Interacts with
921 drugs
250 mg per serving

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...

Propolis Extract, Natural monograph & interactions

Other (inactive) ingredients: Glycerol, Water, Purified, Anethole, Peppermint Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Children's Ultra Clear Propolis Liquid by CATALO Drug Interactions

Want to check YOUR meds against Children's Ultra Clear Propolis Liquid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
921Drugs
921 Moderate

Ingredients driving the most interactions

Propolis Extract, Natural 921

Individual Drug Interactions

The ingredients in Children's Ultra Clear Propolis Liquid interact with 921 drugs. Click any drug to see the details.

1 of the 1 ingredient in Children's Ultra Clear Propolis Liquid interact with drugs. Each result below shows which ingredient is responsible. Propolis Extract, Natural

Each ingredient & the kinds of drugs it affects

For each ingredient in Children's Ultra Clear Propolis Liquid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Propolis Extract, Natural8 drug types · 921 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.

Likelihood Possible Evidence D
Propolis Extract, Natural full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Children's Ultra Clear Propolis Liquid, from the product label.

CATALO

See all CATALO products
Name
CATALO
Pharmacist Counseling Corner

Children's Ultra Clear Propolis Liquid by CATALO: Common Questions

Does Children's Ultra Clear Propolis Liquid by CATALO interact with any medications?
Yes. Based on its ingredients, Children's Ultra Clear Propolis Liquid has a known interaction with 921 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Children's Ultra Clear Propolis Liquid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe for children with a bee allergy?
No. Propolis is made from bee-collected resin, and children allergic to bees or bee products are more likely to have allergic reactions to it. If your child has any bee allergy, avoid this product and talk with your pediatrician.
What side effects might my child experience?
Headache is the most common side effect — around 7% of people taking propolis reported mild headache in one trial. Allergic reactions are possible but rare. If your child develops hives, swelling, breathing trouble, or severe itching, stop and seek medical attention.
Does propolis really work for cold sores?
The evidence rates propolis as possibly effective for cold sores (herpes labialis). That means some studies show benefit, but the evidence isn't yet conclusive. Talk with your pediatrician about whether it's right for your child's situation.
Can I give this during pregnancy or breastfeeding?
There isn't enough reliable safety information, so propolis should be avoided during pregnancy and breastfeeding. Talk with your doctor or midwife if you have questions.
What exactly is propolis?
Propolis is a resinous material that honeybees collect and use to seal their hives. This product contains a natural extract of it, mixed with glycerol, water, anethole, and peppermint oil for flavor and consistency.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Children's Ultra Clear Propolis Liquid label
Go deeper

The Full Monographs Behind Children's Ultra Clear Propolis Liquid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Propolis

Interacts with 921 drugs

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...

Read the full Propolis monograph →
Sources

Sources & How We Checked

Children's Ultra Clear Propolis Liquid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Propolis 21 references
  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  16. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
  17. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
  18. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
  19. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
  20. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
  21. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed

See these in context on the Propolis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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