Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Cholesterol Formula With Sytrinol Ingredients & Drug Interactions

by Natural Factors

Cholesterol Formula With Sytrinol label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cholesterol Formula With Sytrinol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Cholesterol Formula With Sytrinol is a dietary supplement by Natural Factors with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Palm Tocotrienols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cholesterol Formula With Sytrinol by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Cholesterol Formula With Sytrinol by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cholesterol Formula With Sytrinol by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Sytrinol” is listed as a grouped ingredient — the label gives one combined amount (150 mg) without saying how much of each component you get.

This formula has 3 active ingredients. The main one is Sytrinol, a blend of natural citrus polymethoxylated flavones and palm tocotrienols — compounds extracted from citrus and palm that some research suggests may help with cholesterol.

The other actives are SterolSource plant sterols, which are cholesterol-like compounds from plants thought to support heart health. The capsule also contains inactive ingredients: gelatin, rice powder, silica, and magnesium stearate, which are standard fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Tocotrienols's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cholesterol support.
  • We looked for evidence on: Hypercholesterolemia, Metabolic syndrome, dyslipidemia, cardiovascular health.
  • The closest evidence on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Tocotrienols is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.

The evidence here is mixed. Tocotrienols show possibly effective rating for diabetes, but possibly ineffective for high cholesterol — so if cholesterol is your main goal, the research doesn't back this ingredient strongly for that.

For alopecia areata (a hair-loss condition) and breast cancer, we don't have enough reliable evidence to say whether tocotrienols help. The effectiveness of the other two active ingredients in this formula isn't rated in our data.

The evidence, ingredient by ingredient Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tocotrienols are generally well tolerated in studies, though long-term safety at supplement doses isn't fully established. When taken by mouth, no adverse effects were reported in clinical trials.

The safety data advises against supplemental tocotrienols during pregnancy. While breastfeeding, there isn't enough information to know whether it's safe — talk with your doctor or pharmacist before using it if you're nursing.

We don't have pregnancy or breastfeeding safety data on file for the other two active ingredients in this formula.

Side effects, ingredient by ingredient Tocotrienols

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any blood thinners or antiplatelet drugs (like warfarin, aspirin, clopidogrel, or dabigatran) before taking this product — tocotrienols may slightly increase bleeding risk, though this hasn't been reported in actual patients. If you're unsure whether your medication is a blood thinner, use the search tool on this page to verify.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Consider this if you're looking for a plant-based cholesterol support formula and don't take blood thinners. If you're on any anticoagulant or antiplatelet medication, check with your pharmacist first — there's a theoretical bleeding risk, even though it hasn't been seen in people.

Pregnant or breastfeeding? Talk to your doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cholesterol Formula With Sytrinol, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958020877
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Oct 27, 2014
DSLD ID 38059
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cholesterol Formula With Sytrinol by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
068958020877
IngredientAmount% DV
Sytrinol150 mg--
natural Citrus Polymethoxylated Flavones0 NP--
SterolSource(TM) Plant Sterols400 mg--
Palm Tocotrienols0 NP--

Other ingredients: Gelatin capsule, Rice powder, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

PRODUCT OF CANADA

Recyclable container and label.

Dr. Michael Murray Formulated SUPPORTS HEART HEALTH*

Formulation

Contains no artificial preservatives, color or sweeteners; no corn, dairy, gluten, wheat or yeast.

Precautions

Sealed for your protection. Do not use if seal is broken.

Contains soy.

Keep out of reach of children.

Storage

For freshness, store in a cool, dry place.

General

R3

FDA Disclaimer Statement

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Purity&Potency Guaranteed

Sytrinol(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

Contains soy.

Dr. Murray’s Cholesterol Formula contains a patent pending combination of plant sterols and Sytrinol(R), a patented compound that promotes heart health.*

Brand IP Statement(s)

SterolSource(TM) is a trademark of Source One Global Partners, LLC. Sytrinol(R) is a registered trademark of KGK Synergize. Use and composition of this proprietary formula is protected by U.S. patents #6,261,400, #6,239,114 and international patents.

Suggested/Recommended/Usage/Directions

Suggested Usage: 2 capsules 2 times per day or as directed by a health professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cholesterol Formula With Sytrinol by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cholesterol Formula With Sytrinol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cholesterol Formula With Sytrinol by Natural Factors

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sytrinol

150 mg per serving

SterolSource(TM) Plant Sterols

400 mg per serving Form: Beta Sitosterol, Campesterol, Stigmasterol

Other (inactive) ingredients: Gelatin capsule, Rice powder, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cholesterol Formula With Sytrinol by Natural Factors Drug Interactions

Want to check YOUR meds against Cholesterol Formula With Sytrinol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

Palm Tocotrienols 122

Individual Drug Interactions

The ingredients in Cholesterol Formula With Sytrinol interact with 122 drugs. Click any drug to see the details.

1 of the 3 ingredients in Cholesterol Formula With Sytrinol interact with drugs. Each result below shows which ingredient is responsible. Palm Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in Cholesterol Formula With Sytrinol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Palm Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Palm Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cholesterol Formula With Sytrinol, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Cholesterol Formula With Sytrinol by Natural Factors: Common Questions

Does Cholesterol Formula With Sytrinol by Natural Factors interact with any medications?
Yes. Based on its ingredients, Cholesterol Formula With Sytrinol has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cholesterol Formula With Sytrinol contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually help with high cholesterol?
The tocotrienol ingredient is rated possibly ineffective for high cholesterol in our data, so the research doesn't strongly support it for that goal. The citrus flavones and plant sterols may work differently, but we don't have effectiveness ratings for those.
Can I take this if I'm on a blood thinner like warfarin?
Tocotrienols might increase bleeding risk in theory, though it's never been reported in humans. Don't start this without checking with your pharmacist first — they can look up your exact medication and tell you whether it's safe for you.
Is it safe to take while pregnant or breastfeeding?
The safety data advises against supplemental tocotrienols during pregnancy. While breastfeeding, there isn't enough information — talk with your doctor before using it. We have no pregnancy or breastfeeding data on the other two active ingredients.
What are plant sterols and why are they in here?
Plant sterols are cholesterol-like compounds from plants that some people believe support heart health. They're included in formulas like this one that aim to support cholesterol levels, though we don't have an effectiveness rating for them in our data.
Are there any common side effects?
When taken by mouth, tocotrienols don't show any adverse effects in clinical trials. We have no side-effect data on the citrus flavones or plant sterols in this formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cholesterol Formula With Sytrinol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cholesterol Formula With Sytrinol label
Go deeper

The Full Monographs Behind Cholesterol Formula With Sytrinol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Cholesterol Formula With Sytrinol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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